INT46714

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2008
Negated 19
Speculated 6
Reported most in Body
Documents 76
Total Number 88
Disease Relevance 75.99
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNC1)
Anatomy Link Frequency
cardiomyocytes 1
myocardial cell 1
thoracic 1
nociceptor 1
TNNC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 173 99.96 Very High Very High Very High
Pain 75 99.68 Very High Very High Very High
Angina 132 99.40 Very High Very High Very High
ischemia 78 98.80 Very High Very High Very High
nociceptor 9 97.52 Very High Very High Very High
Hyperalgesia 5 95.76 Very High Very High Very High
iatrogenic 3 94.20 High High
Inflammation 70 92.88 High High
Analgesic 136 83.48 Quite High
c fibre 1 82.44 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 6451 100.00 Very High Very High Very High
Acute Coronary Syndrome 57 100.00 Very High Very High Very High
Chronic Renal Failure 13 100.00 Very High Very High Very High
Pulmonary Embolism 138 99.96 Very High Very High Very High
Critical Illness 1030 99.92 Very High Very High Very High
Pain 73 99.68 Very High Very High Very High
Heart Rate Under Development 340 99.52 Very High Very High Very High
Necrosis 209 99.48 Very High Very High Very High
Injury 173 99.46 Very High Very High Very High
Cv General 3 Under Development 47 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardiac troponin levels are frequently elevated in patients with chronic renal failure, hence diagnosis of myocardial necrosis is difficult.
Positive_regulation (elevated) of Cardiac troponin associated with necrosis and chronic renal failure
1) Confidence 0.67 Published 2008 Journal Asian Cardiovasc Thorac Ann Section Abstract Doc Link 18670019 Disease Relevance 0.72 Pain Relevance 0.07
Another issue influencing analysis of the impact of elevated cTn levels is that ECG interpretation, often done concurrently in practice, may have only moderate inter and intra-rater reliability in the ICU setting, which improves with knowledge of the cTn levels [10].
Positive_regulation (elevated) of cTn
2) Confidence 0.59 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.59 Pain Relevance 0
We documented that elevated cTn levels are associated with hospital mortality, even after adjusting for other important potential confounders.
Positive_regulation (elevated) of cTn
3) Confidence 0.59 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.87 Pain Relevance 0
We defined an elevated cTn as one or more measurements of cTnT with values greater than or equal to 0.04 ?
Positive_regulation (elevated) of cTn
4) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.66 Pain Relevance 0
A total of 37 patients (35.9 per cent) had MI, 15 patients (14.6 per cent) had elevated cTn only (that is isolated cTn elevation), and 51 patients (49.5 per cent) had no cTn elevation.
Positive_regulation (elevation) of cTn associated with myocardial infarction
5) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.59 Pain Relevance 0.03
Both elevated cTn and MI were associated with ICU mortality and hospital mortality in univariable analysis.
Positive_regulation (elevated) of cTn associated with myocardial infarction
6) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.50 Pain Relevance 0
A total of 37 patients (35.9 per cent) had MI, 15 patients (14.6 per cent) had elevated cTn only (that is isolated cTn elevation), and 51 patients (49.5 per cent) had no cTn elevation.
Positive_regulation (elevated) of cTn associated with myocardial infarction
7) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.58 Pain Relevance 0.03
We found that 81 per cent of patients admitted to the ICU had at least 1 cTn measurement and 1 ECG; of these patients, 47 per cent had at least 1 elevated cTn level and 26 per cent met diagnostic criteria for MI by similar adjudication criteria as in the current study (elevated cTn and ischaemic ECG changes).
Positive_regulation (elevated) of cTn associated with myocardial infarction
8) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.71 Pain Relevance 0.16
We found that elevated cTn was associated with increased hospital mortality (OR 27.3, 95 per cent CI 1.7 – 449.4).
Positive_regulation (elevated) of cTn
9) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 1.01 Pain Relevance 0
Patients with elevated cTn had higher hospital mortality (26.7 per cent versus 2.0 per cent, p = 0.001) compared with patients without cTn elevation.
Positive_regulation (elevated) of cTn
10) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.57 Pain Relevance 0
Elevated cTn was associated with hospital mortality (OR 27.3, 95 per cent CI 1.7–449.4), but not ICU mortality in multivariable analysis after adjusting for illness severity and need for advanced life support.
Positive_regulation (Elevated) of cTn
11) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.43 Pain Relevance 0
In unadjusted analyses with significant heterogeneity of results, elevated cTn was associated with an increased mean length of ICU stay of three days (95 per cent CI 0.98–5.05).
Positive_regulation (elevated) of cTn
12) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.73 Pain Relevance 0
In another study, ICU patients admitted with non-cardiac diagnoses who had an elevated cTn were found to have a four-fold higher mortality (22.4 vs. 5.2 per cent, p < 0.018) than patients without cTn elevation [5].
Positive_regulation (elevated) of cTn
13) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.86 Pain Relevance 0
We found that 81 per cent of patients admitted to the ICU had at least 1 cTn measurement and 1 ECG; of these patients, 47 per cent had at least 1 elevated cTn level and 26 per cent met diagnostic criteria for MI by similar adjudication criteria as in the current study (elevated cTn and ischaemic ECG changes).
Positive_regulation (elevated) of cTn associated with myocardial infarction
14) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.68 Pain Relevance 0.15
Elevated cTn appears to be an adverse prognostic marker among critically ill patients.
Positive_regulation (Elevated) of cTn associated with critical illness
15) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 1.10 Pain Relevance 0
Similar results were observed in the sensitivity analysis where inotrope and/or vasopressor use was omitted from the regression; after adjusting for illness severity and need for mechanical ventilation and haemodialysis, elevated cTn was significantly associated with hospital mortality (OR 19.7, 95 per cent CI 1.5–260.4)
Positive_regulation (elevated) of cTn
16) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.63 Pain Relevance 0
Table 2 shows the morbidity and mortality outcomes of the patients with MI, elevated cTn only and no cTn elevation.
Positive_regulation (elevated) of cTn associated with myocardial infarction
17) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.60 Pain Relevance 0
Recognising critically ill patients who have MI (versus an elevated cTn alone) may be important since these patients may benefit from antithrombotic and anti-ischaemic medications that have been shown to benefit non-critically ill patients.
Positive_regulation (elevated) of cTn associated with critical illness and myocardial infarction
18) Confidence 0.51 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.64 Pain Relevance 0.06
Elevation of cTn is usually related to myocardial damage but is not synonymous with acute coronary syndrome.
Positive_regulation (Elevation) of cTn associated with acute coronary syndrome
19) Confidence 0.51 Published 2008 Journal Am J Emerg Med Section Abstract Doc Link 18358946 Disease Relevance 0.63 Pain Relevance 0.11
Because of the elevated baseline cardiac troponin T levels, detection of acute coronary syndrome in patients with chronic renal failure requires evaluation of serial cardiac enzyme measurements and serial 12-lead electrocardiograms.
Positive_regulation (requires) of cardiac troponin associated with acute coronary syndrome and chronic renal failure
20) Confidence 0.48 Published 2008 Journal Asian Cardiovasc Thorac Ann Section Abstract Doc Link 18670019 Disease Relevance 0.90 Pain Relevance 0.08

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