INT46721

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 20.40
Pain Relevance 6.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
macrophage 2
brain 2
T cells 2
tanycytes 1
plasma 1
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 339 100.00 Very High Very High Very High
dexamethasone 94 100.00 Very High Very High Very High
Pain 19 100.00 Very High Very High Very High
chemokine 114 99.44 Very High Very High Very High
metalloproteinase 32 99.00 Very High Very High Very High
corticosteroid 12 98.28 Very High Very High Very High
Lasting pain 3 97.76 Very High Very High Very High
Inflammatory marker 1 97.76 Very High Very High Very High
Inflammation 250 97.60 Very High Very High Very High
Multiple sclerosis 75 93.56 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 419 100.00 Very High Very High Very High
Cancer 77 100.00 Very High Very High Very High
Pain 21 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Disease Progression 16 99.92 Very High Very High Very High
Cognitive Disorder 59 99.76 Very High Very High Very High
Recurrence 20 99.68 Very High Very High Very High
Leukocytosis 2 99.32 Very High Very High Very High
Pulmonary Alveolar Proteinosis 34 99.18 Very High Very High Very High
Autoimmune Disease 13 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Few randomized controlled trials of GM-CSF have shown a clear, significant reduction in HIV replication.
Regulation (controlled) of GM-CSF associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.45 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 0.99 Pain Relevance 0
Effect of GM-CSF on plasma HIV RNA levels
Regulation (Effect) of GM-CSF in plasma associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.45 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1164429 Disease Relevance 1.03 Pain Relevance 0
CSF endorphin levels in the two pain groups differed significantly from both the control group and each other.
Regulation (differed) of CSF in CSF associated with pain
3) Confidence 0.44 Published 1982 Journal Anesthesiology Section Abstract Doc Link 7091714 Disease Relevance 0.76 Pain Relevance 0.85
CSF biomarkers are also very sensitive to the fine changes in brain that occur in the preclinical stages of the AD.
Regulation (sensitive) of CSF in brain associated with disease
4) Confidence 0.36 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.41 Pain Relevance 0.18
Moreover, this study highlights an important change in CSF ADC markers in HAART-treated patients.
Regulation (change) of CSF
5) Confidence 0.31 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.30 Pain Relevance 0
Assumably, specialized ependymal cells, the tanycytes, act as a flexible barrier controlling the exchange of substances between CVO and the surrounding brain parenchyma as well as the CSF [3,4].
Regulation (controlling) of CSF in tanycytes
6) Confidence 0.28 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.31 Pain Relevance 0.31
However, AA did not affect GM-CSF concentrations, presumably because there was no difference in this cytokine's concentration between LPS-stimulated and untreated cells (Table 1), this is in accordance with a previous report in which GM-CSF concentrations of cell lysates was less than 40% that of the corresponding supernatants [25].
Neg (not) Regulation (affect) of GM-CSF associated with cytokine
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.20 Pain Relevance 0.40
GM-CSF seems to have the most profound effects on DC functions (Sallusto et al 1994), compared to other factors, such as interferon-?
Regulation (effects) of GM-CSF
8) Confidence 0.25 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503669 Disease Relevance 0.44 Pain Relevance 0
-2 microglobulin levels from baseline were compared with CSF HIV-1 RNA changes by treatment group.
Regulation (changes) of CSF associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.21 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.82 Pain Relevance 0
As dexamethasone did not influence the CSF concentrations of other MMPs this suggests a specific mode of action.
Neg (not) Regulation (influence) of CSF associated with metalloproteinase and dexamethasone
10) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.77 Pain Relevance 0.45
Our previous investigations failed to demonstrate a significant effect of dexamethasone on serial CSF cytokines or chemokines, although CSF protein fell faster in the dexamethasone treated group and there was a trend toward lower IFN-?
Regulation (effect) of CSF associated with chemokine, dexamethasone and cytokine
11) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.78 Pain Relevance 0.46
CSF from naïve animals was used as control.


Regulation (control) of CSF
12) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.23 Pain Relevance 0.13
While early-phase clinical trials targeting GM-CSF and M-CSF have been initiated, no clinical trials on depletion of G-CSF have yet been reported (18).
Regulation (targeting) of CSF
13) Confidence 0.14 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.90 Pain Relevance 0.40
While early-phase clinical trials targeting GM-CSF and M-CSF have been initiated, no clinical trials on depletion of G-CSF have yet been reported (18).
Regulation (targeting) of CSF
14) Confidence 0.14 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.90 Pain Relevance 0.40
It would be helpful in the future to determine whether patients involved in trials experience changes in biomarkers in blood or CSF (such as A?
Spec (whether) Regulation (changes) of CSF in blood
15) Confidence 0.11 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.51 Pain Relevance 0.42
Anti-INA is a novel aAb in the sera and CSF of NPSLE and the CSF anti-INA levels correlate with cognitive impairment
Regulation (correlate) of CSF associated with cognitive disorder
16) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.32 Pain Relevance 0.03
With the exception of well defined changes in the CCL2, CCL3 and CCL5 levels in the CSF during relapses, most investigators observed no differences in various clinical forms of the disease [56,61,64,66].
Neg (exception) Regulation (changes) of CSF associated with disease and recurrence
17) Confidence 0.10 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.35 Pain Relevance 0.77
effect on mRNA level of GM-CSF was less marked.
Regulation (effect) of GM-CSF
18) Confidence 0.10 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.35 Pain Relevance 0.20
Anti-INA is a novel aAb in the sera and CSF of NPSLE and the CSF anti-INA levels correlate with cognitive impairment
Regulation (correlate) of CSF associated with cognitive disorder
19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.32 Pain Relevance 0.03
In a recent study, Sinclair et al. showed that HAART despite treatment failures with no effect on peripheral viral load, had nevertheless a significant beneficial impact on CSF viral load, CSF pleocytosis, and immune activation [140].
Regulation (impact) of CSF associated with leukocytosis
20) Confidence 0.09 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.79 Pain Relevance 0.03

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