INT46734

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Context Info
Confidence 0.16
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.44
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Stub1) protein binding, bridging (Stub1) enzyme binding (Stub1)
protein maturation (Stub1) ligase activity (Stub1) cytoplasm (Stub1)
Anatomy Link Frequency
bladder 3
neuronal 1
neurons 1
L1210 1
Stub1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 50 96.92 Very High Very High Very High
cytokine 172 96.32 Very High Very High Very High
Inflammation 182 88.08 High High
Inflammatory response 22 81.04 Quite High
local anesthetic 2 75.00 Quite High
Inflammatory stimuli 17 56.64 Quite High
Arthritis 15 5.00 Very Low Very Low Very Low
interstitial cystitis 8 5.00 Very Low Very Low Very Low
Crohn's disease 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 63 97.08 Very High Very High Very High
Overactive Bladder 17 96.44 Very High Very High Very High
INFLAMMATION 222 88.08 High High
Microphthalmia 23 43.84 Quite Low
Hypersensitivity 22 23.96 Low Low
Pressure And Volume Under Development 22 5.00 Very Low Very Low Very Low
Granuloma 22 5.00 Very Low Very Low Very Low
Cancer 19 5.00 Very Low Very Low Very Low
Cystitis 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The disadvantage of the CHIP/Q-PCR method is the amount of chromatin necessary for CHIP, which limits this analysis to the whole bladder and not to specific layers (mucosa and detrusor) used for EMSA.
Positive_regulation (necessary) of CHIP in bladder associated with overactive bladder
1) Confidence 0.16 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.45 Pain Relevance 0.18
Using ChIP, the specific binding of NFAT1 and the transactivating NF-?
Positive_regulation (Using) of ChIP
2) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
The disadvantage of the CHIP/Q-PCR method is the amount of chromatin necessary for CHIP, which limits this analysis to the whole bladder and not the specific layers.
Positive_regulation (necessary) of CHIP in bladder
3) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.28 Pain Relevance 0.39
The disadvantage of the CHIP/Q-PCR method is the amount of chromatin necessary for CHIP, which limits this analysis to the whole bladder and not the specific layers.
Positive_regulation (necessary) of CHIP in bladder
4) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.28 Pain Relevance 0.39
To determine CaRF-specific binding sites, we developed an algorithm to identify the sequences specifically enriched in the ChIP samples from Carf WT neurons relative to the negative control ChIP samples from Carf KO neurons.
Positive_regulation (samples) of ChIP in neurons associated with targeted disruption
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.25 Pain Relevance 0
In this case, for our negative control we performed ChIP with the same anti-CaRF antiserum from neuronal cultures made from Carf KO mice, which are null for CaRF protein.
Positive_regulation (performed) of ChIP in neuronal associated with targeted disruption
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877716 Disease Relevance 0.18 Pain Relevance 0
The addition of fresh serum-containing growth medium to L1210 mouse leukemic cells in culture resulted in a 5-fold increase in ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity.
Positive_regulation (increase) of carboxy-lyase in L1210
7) Confidence 0.01 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7093304 Disease Relevance 0 Pain Relevance 0.13

General Comments

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