INT46736

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Context Info
Confidence 0.51
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.60
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
colon 1
small intestines 1
Odc1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 12 97.24 Very High Very High Very High
Inflammation 24 97.12 Very High Very High Very High
local anesthetic 2 91.92 High High
COX-2 inhibitor 4 70.56 Quite High
Inflammatory mediators 5 67.36 Quite High
aspirin 2 59.28 Quite High
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
imagery 10 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 1 99.98 Very High Very High Very High
Targeted Disruption 4 98.76 Very High Very High Very High
Colon Cancer 84 98.64 Very High Very High Very High
INFLAMMATION 34 97.12 Very High Very High Very High
Adenoma 129 96.20 Very High Very High Very High
Cancer 166 95.72 Very High Very High Very High
Familial Adenomatous Polyposis 481 94.32 High High
Polyps 136 93.44 High High
Residual Neoplasm 1 92.44 High High
Toxicity 12 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preclinical studies have demonstrated that DFMO (difluoromethylornithine), an irreversible inhibitor of ODC (ornithine decarboxylase) which is the first enzyme in polyamine biosynthesis, combined with NSAIDs (non-steroidal anti-inflammatory drugs) suppresses colorectal carcinogenesis in murine models.
Negative_regulation (inhibitor) of ODC associated with inflammation and cinod
1) Confidence 0.51 Published 2009 Journal Essays Biochem. Section Abstract Doc Link 20095973 Disease Relevance 0.70 Pain Relevance 0.35
Preclinical studies have demonstrated that DFMO (difluoromethylornithine), an irreversible inhibitor of ODC (ornithine decarboxylase) which is the first enzyme in polyamine biosynthesis, combined with NSAIDs (non-steroidal anti-inflammatory drugs) suppresses colorectal carcinogenesis in murine models.
Negative_regulation (inhibitor) of ornithine decarboxylase associated with inflammation and cinod
2) Confidence 0.51 Published 2009 Journal Essays Biochem. Section Abstract Doc Link 20095973 Disease Relevance 0.76 Pain Relevance 0.35
Among the six ionophores tested, valinomycin was the most potent one, with I50 value (concentration that gives 50% inhibition of ornithine decarboxylase activity) of 6.10(-9) M.
Negative_regulation (inhibition) of ornithine decarboxylase
3) Confidence 0.51 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7093304 Disease Relevance 0 Pain Relevance 0.17
This agency has also designated eflornithine hydrochloride, an irreversible inhibitor of ornithine decarboxilase (ODC), the first and rate-limiting enzyme in the polyamine synthesis, as an orphan medical product to be investigated for use in individuals with FAP [110].
Negative_regulation (inhibitor) of ODC associated with familial adenomatous polyposis
4) Confidence 0.42 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.22 Pain Relevance 0.04
These experiments suggest that selective COX-2 inhibition combined with ODC inhibition is a very promising approach for colon cancer prevention.
Negative_regulation (inhibition) of ODC in colon associated with colon cancer
5) Confidence 0.41 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10766173 Disease Relevance 1.00 Pain Relevance 0
Some of the Cox-2 dependent genes from this study have been previously identified as being influenced by Cox-2 or Cox-2 inhibition (Gast, Icam1, Odc), but the remainder are novel and point to new links between Cox-2 and inflammatory processes, epithelial repair and integrity.
Negative_regulation (inhibition) of Odc associated with inflammation
6) Confidence 0.37 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.61 Pain Relevance 0.18
Additionally, celecoxib suppressed intestinal steady state ornithine decarboxylase RNA levels (p < 0.001), induced steady state spermidine/spermine N(1)-acetyltransferase RNA levels (p = 0.002), decreased putrescine levels (p = 0.04) and decreased tumor number in the small intestines of Apc(Min/+)Nos2(+/+) mice (p = 0.0003).
Negative_regulation (suppressed) of ornithine decarboxylase RNA in small intestines associated with cancer
7) Confidence 0.15 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17096347 Disease Relevance 0.91 Pain Relevance 0.24
Grape seed polyphenols extract containing mainly oligomeric and polymeric proanthocyanidins was shown to inhibit epidermal ODC activity in mice.
Negative_regulation (inhibit) of ODC
8) Confidence 0.07 Published 2009 Journal Phytochem Rev Section Body Doc Link PMC2928446 Disease Relevance 0.83 Pain Relevance 0.04
It is a specific and irreversible suicide inhibitor of ornithine decarboxylase [46,48], the first enzyme involved in polyamine biosynthesis.
Negative_regulation (inhibitor) of ornithine decarboxylase associated with suicidal behaviour
9) Confidence 0.02 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2848007 Disease Relevance 0.36 Pain Relevance 0
This agency has also designated eflornithine hydrochloride, an irreversible inhibitor of ornithine decarboxilase (ODC), the first and rate-limiting enzyme in the polyamine synthesis, as an orphan medical product to be investigated for use in individuals with FAP [110].
Negative_regulation (inhibitor) of ornithine decarboxilase associated with familial adenomatous polyposis
10) Confidence 0.01 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.21 Pain Relevance 0.04

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