INT46759

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Context Info
Confidence 0.60
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 4.83
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACOT2) lipid metabolic process (ACOT2)
Anatomy Link Frequency
MCF-7 3
MDA-MB-231 3
paw 2
ACOT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 99.70 Very High Very High Very High
Analgesic 12 99.26 Very High Very High Very High
headache 1 95.44 Very High Very High Very High
cINOD 10 29.72 Quite Low
COX2 10 5.00 Very Low Very Low Very Low
COX-2 inhibitor 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 99.70 Very High Very High Very High
Breast Cancer 370 99.62 Very High Very High Very High
Hypocalcemia 2 95.52 Very High Very High Very High
Headache 1 95.44 Very High Very High Very High
Pressure Volume 2 Under Development 1 94.92 High High
Toxicity 3 90.64 High High
Pressure And Volume Under Development 2 89.20 High High
Aggression 60 86.56 High High
Injury 210 65.04 Quite High
Hepatocellular Cancer 50 64.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For diagnostic use, 20 microgram of 1-34 hPTH administered intravenously was found to produce effects almost equivalent to those of 200 USPU U of Parathormone (PTE, Eli Lilly).
Gene_expression (produce) of PTE
1) Confidence 0.60 Published 1982 Journal Pharmatherapeutica Section Abstract Doc Link 7100226 Disease Relevance 0.63 Pain Relevance 0.10
In addition overexpression of ACOT2 also increased the levels of the lipooxygenase metabolites.
Gene_expression (overexpression) of ACOT2
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.09 Pain Relevance 0
Interestingly, neither overexpression nor inhibition of ACOT2 expression in MCF-7, a cell that expresses low amounts of ACSL4, has an effect on cell proliferation.
Gene_expression (expression) of ACOT2 in MCF-7
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.31 Pain Relevance 0
However, the phenotype was changed by both overexpression and knockdown of ACOT2 in MDA-MB-231 cells that express high levels of ACSL4.
Gene_expression (overexpression) of ACOT2 in MDA-MB-231
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.14 Pain Relevance 0
ACOT2 expression was also evident in both cell lines (Fig. 4A).
Gene_expression (expression) of ACOT2
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.48 Pain Relevance 0
Increased expression of ACOT2 associated with the aggressive cell phenotype was also observed.
Gene_expression (expression) of ACOT2
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.28 Pain Relevance 0
In parallel with the expression of ACSL4 and ACOT2, intramitochondrial AA levels were significantly higher in MDA-MB-231 than in MCF-7 cells (Fig. 4B).
Gene_expression (expression) of ACOT2 in MDA-MB-231
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.28 Pain Relevance 0
In this study for developing potent analgesic and anti-inflammatory compounds, we synthesized 6-acyl-2-benzoxazolinone and 6-acyl-2-benzothiazolinone derivatives with acetic acid and propanoic acid side chain, and performed preliminary screening of their in vivo analgesic and anti-inflammatory activities at a single dose of 100 mg/kg inmice by a p-benzoquinone-induced writhing test and a Carrageenaninduced hind paw edema model, respectively.
Gene_expression (synthesized) of 6-acyl-2-benzoxazolinone in paw associated with pressure and volume under development, inflammation and analgesic
8) Confidence 0.41 Published 2003 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 14502755 Disease Relevance 0.42 Pain Relevance 0.55
In this study for developing potent analgesic and anti-inflammatory compounds, we synthesized 6-acyl-2-benzoxazolinone and 6-acyl-2-benzothiazolinone derivatives with acetic acid and propanoic acid side chain, and performed preliminary screening of their in vivo analgesic and anti-inflammatory activities at a single dose of 100 mg/kg inmice by a p-benzoquinone-induced writhing test and a Carrageenaninduced hind paw edema model, respectively.
Gene_expression (synthesized) of 6-acyl-2-benzothiazolinone in paw associated with pressure and volume under development, inflammation and analgesic
9) Confidence 0.41 Published 2003 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 14502755 Disease Relevance 0.47 Pain Relevance 0.58
To investigate whether a similar mechanism operates in breast cancer cells, we studied ACOT2 expression and intramitochondrial AA and lipooxygenase metabolites levels in the MDA-MB-231 and MCF-7 cell lines.
Gene_expression (expression) of ACOT2 in MCF-7 associated with breast cancer
10) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.62 Pain Relevance 0
Polyclonal rabbit anti-human ACSL4 and anti-human ACOT2 antibodies were generated in our laboratory [47], [48], whereas monoclonal mouse anti-?
Gene_expression (antibodies) of ACOT2
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.18 Pain Relevance 0
Interestingly, neither overexpression nor inhibition of ACOT2 expression in MCF-7, a cell that expresses low amounts of ACSL4, has an effect on cell proliferation.
Gene_expression (expression) of ACOT2 in MCF-7
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.31 Pain Relevance 0
To investigate whether a similar mechanism operates in breast cancer cells, we studied ACOT2 expression and intramitochondrial AA and lipooxygenase metabolites levels in the MDA-MB-231 and MCF-7 cell lines.
Gene_expression (expression) of ACOT2 in MDA-MB-231 associated with breast cancer
13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.62 Pain Relevance 0

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