INT46766

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.27
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
Th1 cells 1
B cells 1
lymphocytes 1
Il2ra (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 32 98.28 Very High Very High Very High
cytokine 74 97.88 Very High Very High Very High
chemokine 13 94.80 High High
Infliximab 6 94.52 High High
qutenza 6 93.56 High High
tolerance 14 93.36 High High
Angina 6 89.40 High High
methotrexate 7 86.68 High High
rheumatoid arthritis 110 81.76 Quite High
withdrawal 4 75.16 Quite High
Disease Link Frequency Relevance Heat
Asthma 104 99.84 Very High Very High Very High
Arthritis 34 98.28 Very High Very High Very High
Cancer 363 97.16 Very High Very High Very High
Metastasis 4 97.04 Very High Very High Very High
Coronary Artery Disease 4 96.20 Very High Very High Very High
Apoptosis 19 95.04 Very High Very High Very High
Myocardial Infarction 1 91.12 High High
Disease 37 90.36 High High
Cv General 3 Under Development 5 89.40 High High
Stable Angina Pectoris 1 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After pindolol on day 0, the CD25 slowly decreased to, but never below, baseline by days 8 to 21.
Negative_regulation (decreased) of CD25
1) Confidence 0.57 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 7102534 Disease Relevance 0.06 Pain Relevance 0.11
The phenotype of activated CD4+T cells treated with arvanil shows a down-regulation of T cell activation markers such as CD25, HLA-DR and CD134/OX40.
Negative_regulation (regulation) of CD25 in T cell
2) Confidence 0.43 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.25 Pain Relevance 0.12
Transfer activity was lost when cells were depleted of CD4(+) or CD25(+) subpopulations.
Negative_regulation (depleted) of CD25
3) Confidence 0.42 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15879089 Disease Relevance 0.39 Pain Relevance 0.14
Our results indicate that clinical trials which propose to utilize CD25 depleting antibodies, or similar Treg depleting approaches, must carefully monitor the effects on normal activated T cells, and adjust dosing schedules accordingly.
Negative_regulation (depleting) of CD25 in T cells
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.48 Pain Relevance 0
The question why CD4+/CD25+ T cells are reduced in asthmatic patients has not been answered yet; however, it has been observed that these cells reveal a reduced response to the chemokines CCL1 and CXCL1 suggesting an impaired recruitment to the lung [137, 138].
Negative_regulation (reduced) of CD25 in T cells associated with asthma and chemokine
5) Confidence 0.21 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.17 Pain Relevance 0.12
Using experimental animal models, it has been demonstrated that depletion of CD25+ T cells before or after the induction of arthritis leads to exacerbation of arthritis with increased cellular and humoral responses, and that transfer of CD4+CD25+ Treg cells at the time of induction of arthritis decreases the severity of disease.
Negative_regulation (depletion) of CD25 in T cells associated with disease and arthritis
6) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.71 Pain Relevance 0.48
The question was then addressed of whether depletion of CD25+ cells from SC of TBM used in the RLM strategy would improve the anti-tumor effect.
Spec (whether) Negative_regulation (depletion) of CD25 associated with cancer
7) Confidence 0.16 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.76 Pain Relevance 0
We found that the reduction of CD4+CD25+Foxp3+ T lymphocytes was consistent with the expansion of Th1 cells in patients with unstable CAD.
Negative_regulation (reduction) of CD25 in Th1 cells associated with coronary artery disease
8) Confidence 0.13 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17512253 Disease Relevance 0.99 Pain Relevance 0.32
Observations over time showed a gradual decrease in the number of HLA-DR+ lymphocytes and sIL-2R levels from weeks 3 through 8 to 12.
Negative_regulation (decrease) of sIL-2R in lymphocytes
9) Confidence 0.12 Published 1997 Journal Circulation Section Body Doc Link 9107167 Disease Relevance 0.11 Pain Relevance 0
Patients treated with prednisone expressed several changes in lymphocyte phenotype i.e. decreasing of activated T cells (CD3+CD25+: 6.9% vs 3.6%, p < 0.01), B cells (CD5+CD19+: 3.4% vs 0.8%, p < 0.001), and NK cells (CD16+: 14.8% vs 8.5, p < 0.01 and CD56+: 16.3% vs 10.7%, p < 0.01).
Negative_regulation (decreasing) of CD25 in B cells
10) Confidence 0.03 Published 1997 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 9312762 Disease Relevance 0.35 Pain Relevance 0.36

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