INT46786

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Context Info
Confidence 0.47
First Reported 1982
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.47
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6pd) oxidoreductase activity (G6pd) nucleus (G6pd)
carbohydrate metabolic process (G6pd) cytoplasm (G6pd)
Anatomy Link Frequency
peroneal nerve 4
G6pd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 10 99.12 Very High Very High Very High
cINOD 4 98.88 Very High Very High Very High
Paracetamol 7 98.82 Very High Very High Very High
diclofenac 1 97.28 Very High Very High Very High
Inflammation 1 83.36 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 99.12 Very High Very High Very High
Stress 3 97.24 Very High Very High Very High
INFLAMMATION 1 83.36 Quite High
Injury 1 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Denervation of the EDL muscle by section of the peroneal nerve 10-20 mm from its entrance to the muscle caused G6PD activity to increase to 170% of control by day 1 and to 200% and 180% of control by days 2 and 4, respectively.
Positive_regulation (caused) of Positive_regulation (increase) of G6PD in peroneal nerve
1) Confidence 0.47 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7108545 Disease Relevance 0 Pain Relevance 0.32
Resistance to acetaminophen hepatotoxicity produced by repeated exposure is partially attributable to upregulation of hepatic G6PD and GR activity as an adaptive and protective response to oxidative stress and glutathione depletion.
Spec (partially) Positive_regulation (attributable) of Spec (partially) Positive_regulation (upregulation) of G6PD associated with stress, paracetamol and hepatotoxicity
2) Confidence 0.43 Published 2000 Journal Hum Exp Toxicol Section Abstract Doc Link 10918522 Disease Relevance 0.39 Pain Relevance 0.37
This conclusion is based upon the observation that subperineural injection of TTX at an identical site in the peroneal nerve caused a small but significant (30%) increase in G6PD activity after 4 days.
Positive_regulation (caused) of Positive_regulation (increase) of G6PD in peroneal nerve associated with tetrodotoxin
3) Confidence 0.41 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7108545 Disease Relevance 0 Pain Relevance 0.40
Indomethacin treatment led to an increase in lipid peroxidation, glutathione peroxidase and glucose-6-phosphate dehydrogenase activities and to a decrease in catalase activity and glutathione levels in gastric mucosa.
Positive_regulation (led) of Positive_regulation (increase) of glucose-6-phosphate
4) Confidence 0.14 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391279 Disease Relevance 0.08 Pain Relevance 0.43

General Comments

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