INT4679

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 55
Total Number 56
Disease Relevance 47.51
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RAPGEF5) intracellular (RAPGEF5)
Anatomy Link Frequency
urine 6
kidney 3
Heart 2
efferent arteriole 1
plasma 1
RAPGEF5 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 46 100.00 Very High Very High Very High
fibrosis 65 99.88 Very High Very High Very High
beta blocker 86 99.84 Very High Very High Very High
cINOD 62 99.64 Very High Very High Very High
adenocard 50 99.58 Very High Very High Very High
epidural 4 99.46 Very High Very High Very High
Morphine 2 99.24 Very High Very High Very High
Clonidine 4 97.08 Very High Very High Very High
ketamine 2 96.60 Very High Very High Very High
Inflammation 84 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Disease 838 100.00 Very High Very High Very High
Proteinuria 403 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 89 100.00 Very High Very High Very High
Depression 50 100.00 Very High Very High Very High
Hypophosphatemia 7 99.96 Very High Very High Very High
Hyperkalemia 17 99.90 Very High Very High Very High
Fibrosis 49 99.88 Very High Very High Very High
Chronic Renal Failure 404 99.84 Very High Very High Very High
Focal Segmental Glomerulosclerosis 7 99.84 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 49 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that chronic inanition due to surreptitious vomiting causes impaired renal diluting ability through decreases in GFR and RPF, irrespective of the levels of plasma AVP and ANP.
Negative_regulation (decreases) of GFR in plasma associated with disorders of creatine metabolism and vomiting
1) Confidence 0.57 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.89 Pain Relevance 0.06
Even though data may imply that a decrease in GFR causes increased blood cadmium concentrations, the inverse associations between the glomerular effect markers and cadmium in urine rather indicate that reduced GFR does not reduce the clearance of cadmium.
Negative_regulation (reduced) of GFR in urine
2) Confidence 0.54 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.47 Pain Relevance 0
Although the cadmium-induced kidney effects in several studies have been associated with decreasing GFR (Järup et al. 1995; Kido et al. 1990; Roels et al. 1989), a positive aspect is that progression of the very early effect may not always occur when the exposure is substantially decreased (Hotz et al. 1999).
Negative_regulation (decreasing) of GFR in kidney
3) Confidence 0.47 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.58 Pain Relevance 0
Even though data may imply that a decrease in GFR causes increased blood cadmium concentrations, the inverse associations between the glomerular effect markers and cadmium in urine rather indicate that reduced GFR does not reduce the clearance of cadmium.
Negative_regulation (decrease) of GFR in urine
4) Confidence 0.47 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.51 Pain Relevance 0
Although neither drug had a long-term effect on GFR or sodium clearance (CNa), indomethacin (six subjects) but not oxaprozin (seven subjects) transiently reduced GFR and CNa.
Negative_regulation (reduced) of GFR
5) Confidence 0.43 Published 1980 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7002426 Disease Relevance 0.25 Pain Relevance 0.24
Our data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition of Cox-1.
Negative_regulation (depression) of GFR associated with inflammation, depression and cinod
6) Confidence 0.42 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215647 Disease Relevance 0.43 Pain Relevance 0.19
All the patients had increased alkaline phosphatase, hypophosphatemia, decreased fractional phosphate tubular reabsorption (TRP) and maximum tubular phosphate reabsorption/glomerular filtration rate ratio (TPO4/GFR).
Negative_regulation (decreased) of GFR associated with hypophosphatemia
7) Confidence 0.42 Published 2006 Journal Pediatr. Nephrol. Section Abstract Doc Link 16252097 Disease Relevance 0.64 Pain Relevance 0.09
All 15 cases had normal serum creatinine, normocalcemia, normal 1,25-dihydroxyvitamin D (1,25-(OH)2D), reduced serum phosphate concentration, reduced urinary calcium excretion and reduced TmP/GFR.
Negative_regulation (reduced) of GFR
8) Confidence 0.42 Published 2002 Journal Acta Paediatr Taiwan Section Abstract Doc Link 11890223 Disease Relevance 0.97 Pain Relevance 0.09
Clonidine preserves RBF and GFR both acutely and chronically, guanabenz decreases RBF acutely but not chronically, and alpha-methyl dopa preserved RBF but decreases GFR.
Negative_regulation (decreases) of GFR associated with clonidine
9) Confidence 0.42 Published 1984 Journal Annu. Rev. Pharmacol. Toxicol. Section Abstract Doc Link 6145385 Disease Relevance 0 Pain Relevance 0.33
In patients with primary hypertension, intravenous administration of 150 mug Clonidin caused a decrease in arterial pressure, renin activity, RPF, GFR and electrolyte excretion.
Negative_regulation (decrease) of GFR associated with hypertension
10) Confidence 0.42 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 1263403 Disease Relevance 0.10 Pain Relevance 0.07
Morphine and fentanyl decrease urine flow and GFR, whilst RBF increases or decreases, depending on whether a direct or indirect measurement technique was used.
Negative_regulation (decreases) of GFR in urine associated with morphine
11) Confidence 0.33 Published 1990 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 2278418 Disease Relevance 0.13 Pain Relevance 0.33
Spinal and epidural anaesthesia only slightly decrease GFR and RBF in proportion to the decrease in mean arterial pressure.
Negative_regulation (decrease) of GFR in Spinal associated with epidural
12) Confidence 0.33 Published 1990 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 2278418 Disease Relevance 0.19 Pain Relevance 0.36
In animals, renal blood flow and GFR are markedly decreased when an NSAID is administered in the presence of renal hypoperfusion.
Negative_regulation (decreased) of GFR in blood associated with cinod
13) Confidence 0.33 Published 1995 Journal Ugeskr. Laeg. Section Abstract Doc Link 7770968 Disease Relevance 0.32 Pain Relevance 0.63
Recently, Herget-Rosenthal and his colleagues found that determining cystatin C levels is a more sensitive test for the early detection of renal function impairment or reduced GFR (1).
Negative_regulation (reduced) of GFR
14) Confidence 0.30 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 1.14 Pain Relevance 0.04
Our results from 68 male gout patients indicate that serum cystatin C is a novel and reliable marker of GFR.
Negative_regulation (marker) of GFR associated with crystal associated disease
15) Confidence 0.30 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.98 Pain Relevance 0
Inhibition of both Cox isoforms by indomethacin caused transient sodium retention and a decline in GFR.
Negative_regulation (decline) of GFR
16) Confidence 0.27 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215647 Disease Relevance 0.34 Pain Relevance 0.19
Even in young children, definite renal pathology has been described even in those who have not yet developed overt proteinuria or decreased GFR (Tondel et al 2008).
Neg (not) Negative_regulation (decreased) of GFR associated with proteinuria
17) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 1.01 Pain Relevance 0.07
Hyperphosphatemia was attributed to decreased GFR whereas the possibility of pseudohyperphosphatemia secondary to multiple myeloma was ruled out with negative SPEP (serum protein electrophoresis).
Negative_regulation (decreased) of GFR associated with multiple myeloma
18) Confidence 0.19 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2329655 Disease Relevance 1.45 Pain Relevance 0
The age-related decline in GFR and the lower prevalence of hyperlipidemia might indicate increased malnutrition and inflammation in patients with severe RD.14,24
Negative_regulation (decline) of GFR associated with appetite loss, inflammation, renal disease and hyperlipidemia
19) Confidence 0.18 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 2.52 Pain Relevance 0.08
Major CVD trials often exclude patients with renal disease, therefore, did not elucidate the effect of interventions and treatment on patients with renal disease.9-11,13 Our analysis confirmed the use of ACEi and BB in improving survival after development of ACS and PCI declined in patients with severe RD, and it is highly possible that complications like cardiogenic shock and AV block were increased while declined in GFR.
Negative_regulation (declined) of GFR in cardiogenic associated with acute coronary syndrome, beta blocker, cv general 2 under development, cardiovascular disease and renal disease
20) Confidence 0.18 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 2.42 Pain Relevance 0.20

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