INT4680

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.66
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RAPGEF5) intracellular (RAPGEF5)
RAPGEF5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 1 75.00 Quite High
Analgesic 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 40 99.28 Very High Very High Very High
Hypertension 33 99.02 Very High Very High Very High
Pathologic Processes 2 87.96 High High
Diabetes Mellitus 16 84.28 Quite High
Death 4 77.16 Quite High
Cardiovascular Disease 6 76.76 Quite High
Disorder Of Lipid Metabolism 14 74.48 Quite High
Chronic Renal Failure 20 73.44 Quite High
Genetic Predisposition To Disease 4 67.40 Quite High
Heart Disease 2 26.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with primary hypertension, intravenous administration of 150 mug Clonidin caused a decrease in arterial pressure, renin activity, RPF, GFR and electrolyte excretion.
Positive_regulation (caused) of Negative_regulation (decrease) of GFR associated with hypertension
1) Confidence 0.45 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 1263403 Disease Relevance 0.10 Pain Relevance 0.07
Blockade of the renin-angiotensin-system (RAS) [3]–[5] has been shown to slow renal function decline in individuals with renal disease, providing evidence that activation of the RAS may promote a more rapid loss of GFR.
Positive_regulation (promote) of Negative_regulation (loss) of GFR associated with renal disease
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.70 Pain Relevance 0
Randomized controlled trials with agents that interrupt the renin-angiotensin-system (RAS) [3]–[5] have demonstrated a slowing of renal function decline in individuals with renal disease, providing strong evidence that activation of the RAS may promote a more rapid loss of GFR in patients with renal disease.
Positive_regulation (promote) of Negative_regulation (loss) of GFR associated with renal disease
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.86 Pain Relevance 0

General Comments

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