INT4681

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Context Info
Confidence 0.68
First Reported 1976
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.69
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RAPGEF5) intracellular (RAPGEF5)
Anatomy Link Frequency
tubules 1
kidney 1
urine 1
RAPGEF5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 3 100.00 Very High Very High Very High
adenocard 14 99.98 Very High Very High Very High
narcan 7 89.76 High High
Endogenous opioid 2 78.40 Quite High
noradrenaline 2 76.80 Quite High
Clonidine 2 75.00 Quite High
fibrosis 26 74.60 Quite High
cINOD 18 55.12 Quite High
cytokine 2 50.28 Quite High
Inflammation 21 44.08 Quite Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 52 100.00 Very High Very High Very High
Nicotine Addiction 39 99.70 Very High Very High Very High
Acute Decompensated Heart Failure (ADHF) 19 99.16 Very High Very High Very High
Crystal Associated Disease 66 98.80 Very High Very High Very High
Hypertension 129 97.80 Very High Very High Very High
Natriuresis 15 94.76 High High
Hyperglycemia 48 94.56 High High
Frailty 7 93.68 High High
Syndrome 47 93.60 High High
Fever 9 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with primary hypertension, intravenous administration of 150 mug Clonidin caused a decrease in arterial pressure, renin activity, RPF, GFR and electrolyte excretion.
Localization (excretion) of GFR associated with hypertension
1) Confidence 0.68 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 1263403 Disease Relevance 0.10 Pain Relevance 0.07
However, because we found cadmium-associated effects on NAG and protein HC even in never-smokers, and there was no effect of smoking on creatinine clearance or GFR, this is unlikely.
Localization (clearance) of GFR associated with nicotine addiction and disorders of creatine metabolism
2) Confidence 0.60 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.63 Pain Relevance 0
The measured renal parameters, both serum cystatin C and serum creatinine, were significantly correlated with GFR of Ccr (Fig. 1).
Localization (correlated) of GFR associated with disorders of creatine metabolism
3) Confidence 0.60 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.89 Pain Relevance 0.11
Until now, traditional measures for assessing renal function such as measuring serum creatinine have been widely used in gout patients, although they have some limitations for accurate estimation of GFR.
Localization (estimation) of GFR associated with crystal associated disease
4) Confidence 0.53 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 1.42 Pain Relevance 0
HOI caused significant decrements of MAP, PRA, aldosterone, and catecholamines, and increased ANP, GFR, from 94 +/- 5 to 102 +/- 5 ml/min (P < 0.01), ERPF, from 529 +/- 30 to 616 +/- 35 ml/min (P < 0.01), and sodium excretion.
Localization (decrements) of GFR associated with catecholamine
5) Confidence 0.29 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7474676 Disease Relevance 0.37 Pain Relevance 0.41
Clearly, accurate and validated measurements of GFR are needed, especially in children if this information is going to be used as a criterion for initiating ERT or following the response to ERT in the individual patient.
Localization (measurements) of GFR
6) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.43 Pain Relevance 0.03
It is work noting that the patient described by Warnock (Warnock 2005) and those described by Schiffman et al (2007) had slowing of their progressive loss of GFR when the ERT dose or frequency was increased above 0.2 mg/kg given every other week.
Localization (loss) of GFR
7) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.65 Pain Relevance 0
Acute delivery of sodium to the distal tubules due to diuretic therapy in ADHF will in turn stimulate further adenosine release and further reduction in the GFR.
Localization (release) of GFR in tubules associated with adenocard and acute decompensated heart failure (adhf)
8) Confidence 0.20 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 1.15 Pain Relevance 0.27
The evaluations of kidney function that should be carried out in every patient include serum creatinin, cystatin C, estimates of GFR, total protein, (micro) albumin excretion and urinary sodium excretion.
Localization (excretion) of GFR in kidney
9) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 1.65 Pain Relevance 0.04
Information on presence of abnormal urine albumin excretion in addition to level of GFR may be used to stage CKD.
Localization (excretion) of GFR in urine
10) Confidence 0.08 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.90 Pain Relevance 0
In any case, combination therapy with ACE inhibitors and CCBs may reduce the slope of GFR reduction.114


Localization (slope) of GFR
11) Confidence 0.06 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.44 Pain Relevance 0
Relationship between e-GFR and AVP, c-AMP and AQP2
Localization (Relationship) of e-GFR
12) Confidence 0.01 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.05 Pain Relevance 0

General Comments

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