INT46827

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.93
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS1) extracellular region (ADAMTS1)
Anatomy Link Frequency
tendon cells 1
puncture 1
ADAMTS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 2 82.72 Quite High
cytokine 22 81.88 Quite High
Pain 30 77.88 Quite High
metalloproteinase 16 75.12 Quite High
cva 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Emergencies 1 98.74 Very High Very High Very High
Overactive Bladder 1 92.44 High High
Quadriplegia 1 89.12 High High
Thrombosis Related Under Development 1 86.00 High High
Hemangioma 2 78.24 Quite High
Pain 4 77.88 Quite High
Spinal Cord Vascular Diseases 5 75.00 Quite High
Vascular Malformations 1 64.96 Quite High
Tendinopathy 20 44.08 Quite Low
Spinal Cord Diseases 1 26.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Emergency myelography via cisternal puncture revealed a central filling defect at the level of C3-C5.
Negative_regulation (defect) of C3-C5 in puncture associated with emergencies
1) Confidence 0.42 Published 1982 Journal No Shinkei Geka Section Abstract Doc Link 7121734 Disease Relevance 0.93 Pain Relevance 0.08
In further contrast with ADAMTS-4, levels of both ADAMTS-1 and ADAMTS-5 mRNA were lower in cells in collagen gel cultures compared with monolayers (Table 1).
Negative_regulation (lower) of ADAMTS-1
2) Confidence 0.13 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.06
We found that placing tendon cells in a three-dimensional collagen gel (a version of the fibroblast-populated collagen lattice: Ehrlich and Rittenberg, 2000; Grinnell, 2003) increased the expression of ADAMTS-4 mRNA relative to the monolayer and decreased that of ADAMTS-1 and ADAMTS-5 (Table 1).
Negative_regulation (decreased) of ADAMTS-1 in tendon cells
3) Confidence 0.06 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.12

General Comments

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