INT4683

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Context Info
Confidence 0.55
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.81
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PDXK) cytosol (PDXK) small molecule metabolic process (PDXK)
nucleolus (PDXK) nucleus (PDXK) cytoplasm (PDXK)
Anatomy Link Frequency
plasma 1
EGOT 1
tendon 1
PDXK (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 361 99.88 Very High Very High Very High
depression 2 99.60 Very High Very High Very High
Inflammation 220 99.52 Very High Very High Very High
Arthritis 30 99.52 Very High Very High Very High
Pain 21 96.68 Very High Very High Very High
carpal tunnel syndrome 3 91.84 High High
Perioperative pain 1 89.20 High High
Dismenorea 3 88.28 High High
Paresthesia 1 73.68 Quite High
cytokine 70 73.04 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 99.96 Very High Very High Very High
Osteoporosis 2 99.92 Very High Very High Very High
Rheumatoid Arthritis 361 99.88 Very High Very High Very High
Atherosclerosis 20 99.80 Very High Very High Very High
Neuropathy 6 99.76 Very High Very High Very High
Carpal Tunnel Syndrome 9 99.70 Very High Very High Very High
Depression 2 99.60 Very High Very High Very High
INFLAMMATION 240 99.52 Very High Very High Very High
Experimental Arthritis 10 99.52 Very High Very High Very High
Syndrome 9 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin B6 deficiency in elderly patients on chronic peritoneal dialysis.
Negative_regulation (deficiency) of Vitamin B6 associated with renal failure
1) Confidence 0.55 Published 2000 Journal Adv Perit Dial Section Title Doc Link 11045317 Disease Relevance 0.78 Pain Relevance 0.11
Polyneuropathy related to decreased levels of Vitamin B6 are well known.
Negative_regulation (decreased) of Vitamin B6 associated with neuropathy
2) Confidence 0.46 Published 2008 Journal Electromyogr Clin Neurophysiol Section Abstract Doc Link 18754531 Disease Relevance 0.39 Pain Relevance 0.06
The author found that 9% of his patients questioned complained of painful penetration, 3% during and 9% after intercourse, probably because of mycoses and insufficient vaginal lubrication. 1 proven effect of the pill is a mild to severe deficiency of Vitamin-B6, causing depression, irritability, and loss of libido.
Negative_regulation (deficiency) of Vitamin-B6 associated with pain, depression, mycoses and reprotox - general 1
3) Confidence 0.32 Published 1976 Journal Contracept Fertil Sex (Paris) Section Abstract Doc Link 12229583 Disease Relevance 0.75 Pain Relevance 0.42
Vitamin B6 deficiency in animals has been related to atherosclerotic lesions [10].
Negative_regulation (deficiency) of Vitamin B6 associated with atherosclerosis
4) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 0.94 Pain Relevance 0.32
Both clinical studies and animal experiments suggest that inflammation causes tissue specific depletion of vitamin B6 [4,5,16].
Negative_regulation (depletion) of vitamin B6 associated with inflammation
5) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 0.91 Pain Relevance 0.49
Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis

Patients with rheumatoid arthritis have subnormal vitamin B6 status, both quantitatively and functionally.

Negative_regulation (deficiency) of vitamin B6 associated with inflammation and rheumatoid arthritis
6) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1297588 Disease Relevance 1.07 Pain Relevance 0.44
Patients with rheumatoid arthritis have reduced circulating levels of vitamin B6 compared to healthy subjects [1-3].
Negative_regulation (reduced) of vitamin B6 associated with rheumatoid arthritis
7) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 0.31 Pain Relevance 0.15
More recently, researchers demonstrated a relationship between vitamin B6 deficiency and atherosclerosis in human population-based studies, and they reported that this relationship was independent of plasma total homocysteine (tHcy) levels both before and after methionine loading [11,12].
Negative_regulation (deficiency) of vitamin B6 in plasma associated with atherosclerosis
8) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 0.90 Pain Relevance 0.28
We recently showed that adjuvant arthritis caused tissue-specific depletion of vitamin B6 in rats [6], suggesting that the impaired vitamin B6 metabolism in patients with rheumatoid arthritis result from inflammation, and these patients may have higher requirements for vitamin B6 than those in a normal healthy population.
Negative_regulation (depletion) of vitamin B6 associated with inflammation, rheumatoid arthritis, experimental arthritis and arthritis
9) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 1.23 Pain Relevance 0.48
There was a mild vitamin B6 treatment effect after adjusting for initial ?
Negative_regulation (effect) of vitamin B6
10) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 0.14 Pain Relevance 0
We previously reported the presence of functional vitamin B6 inadequacy in rheumatoid arthritis patients: ?
Negative_regulation (presence) of vitamin B6 associated with rheumatoid arthritis
11) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 1.12 Pain Relevance 0.59
Conversely, the disrupted homocysteine metabolism may not be simply due to vitamin B6 inadequacy in these patients as 2 of the 14 subjects in the B6 group with abnormal initial ?
Negative_regulation (inadequacy) of vitamin B6
12) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297588 Disease Relevance 0.49 Pain Relevance 0.11
Impaired vitamin B6 status could be a result of inflammation, and these patients may have higher demand for vitamin B6.
Negative_regulation (Impaired) of vitamin B6 associated with inflammation
13) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297588 Disease Relevance 1.07 Pain Relevance 0.43
There is only one more report of spontaneous atraumatic rupture of distal ilio-psoas tendon in two patients (without arthroplasty); however their medical history was complicated by rheumatoid arthritis, diffuse non-myelinating polyneuropathy, Parkinsonism, Vitamin B-12 deficiency, osteoporosis and Alzheimer's disease [11].
Negative_regulation (deficiency) of Vitamin B-12 in tendon associated with parkinson's disease, neuropathy, rupture, rheumatoid arthritis, osteoporosis and disease
14) Confidence 0.02 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2826299 Disease Relevance 1.67 Pain Relevance 0.28
Vitamin B6 deficiency in patients with a clinical syndrome including the carpal tunnel defect.
Negative_regulation (deficiency) of Vitamin B6 associated with syndrome and carpal tunnel syndrome
15) Confidence 0.02 Published 1976 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 1265347 Disease Relevance 0.29 Pain Relevance 0.09
It is concluded that patients with a severe syndrome including the carpal tunnel defect have a deficiency of vitamin B6, and that both the syndrome and the deficiency are relived by therapy with pyridoxine.
Negative_regulation (deficiency) of vitamin B6 associated with syndrome and carpal tunnel syndrome
16) Confidence 0.01 Published 1976 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1265347 Disease Relevance 0.50 Pain Relevance 0.05
Before treatment, the patients showed a deficiency of vitamin B6 as determined by 1) a comparison of the specific activities of EGOT with those of a control group (P less than 0.001); and 2) a differential assay based upon the principle of unsaturation and saturation of a Coenzyme-Apoenzyme System (CAS), as applied to EGOT.
Negative_regulation (deficiency) of vitamin B6 in EGOT
17) Confidence 0.01 Published 1976 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1265347 Disease Relevance 0.24 Pain Relevance 0.09

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