INT46833

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 56
Total Number 58
Disease Relevance 24.49
Pain Relevance 30.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
spinal 4
lung 3
heart 2
plasma 1
spinal cord 1
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 8 100.00 Very High Very High Very High
Hyperalgesia 3 100.00 Very High Very High Very High
Opioid 32 99.98 Very High Very High Very High
cva 544 99.96 Very High Very High Very High
cINOD 109 99.90 Very High Very High Very High
Nicotine 14 99.90 Very High Very High Very High
Neuropathic pain 7 99.84 Very High Very High Very High
methadone 14 99.74 Very High Very High Very High
Enkephalin 14 99.66 Very High Very High Very High
Kinase C 17 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paratuberculosis 80 100.00 Very High Very High Very High
Injury 57 100.00 Very High Very High Very High
Hyperalgesia 3 100.00 Very High Very High Very High
Pneumoperitoneum 9 99.98 Very High Very High Very High
Cv General 3 Under Development 532 99.96 Very High Very High Very High
Nervous System Injury 5 99.92 Very High Very High Very High
Neuropathic Pain 7 99.84 Very High Very High Very High
Colon Cancer 25 99.52 Very High Very High Very High
Hypothermia 4 99.00 Very High Very High Very High
Stress 18 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insertion of the pins led to a significant increase in HR, SAP, MAP and DAP in the control group.
Positive_regulation (increase) of MAP
1) Confidence 0.67 Published 1999 Journal Anaesthesiol Reanim Section Abstract Doc Link 10372436 Disease Relevance 0.06 Pain Relevance 0.36
In addition, p38 MAP kinase was not activated under these conditions.
Neg (not) Positive_regulation (activated) of MAP
2) Confidence 0.67 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.21
Activation of p38 and p42/44 MAP kinases in spinal cord ipsilateral to constriction injury was reduced by antagonists of NMDA, VPAC2 and NK2 (but not related) receptors, the glial inhibitor propentofylline and inhibitors of TNF-alpha.
Positive_regulation (Activation) of MAP in spinal cord associated with antagonist, injury and spinal cord
3) Confidence 0.67 Published 2005 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16202621 Disease Relevance 0.27 Pain Relevance 0.35
In the current report, we provide additional evidence that exposure to butyrate causes a rapid activation of the MAP kinase pathway, associated with increased phosphorylation of CREB.
Positive_regulation (activation) of MAP
4) Confidence 0.67 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
A 25 microM H(2)O(2), unable to stimulate by itself the MAP kinases, promote an almost complete activation of MAP kinases in the presence of NSAIDs.
Positive_regulation (activation) of MAP associated with cinod
5) Confidence 0.67 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.46 Pain Relevance 0.92
In cultured astrocytes, a biological system less sensitive to oxidative stress, we show that a short treatment by NSAIDs strongly activated the three MAP kinases in the presence of H(2)O(2).
Positive_regulation (activated) of MAP in astrocytes associated with stress and cinod
6) Confidence 0.67 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.46 Pain Relevance 0.84
Increases in SAP, MAP, DAP, and HR did not differ significantly between groups.
Positive_regulation (Increases) of MAP
7) Confidence 0.67 Published 1999 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 10213433 Disease Relevance 0 Pain Relevance 0.06
Acute treatment of DOR cells with DADL caused a 3-fold increase in the level of phosphorylated mitogen-activated protein (MAP) kinase.
Positive_regulation (increase) of MAP associated with enkephalin and opioid receptor
8) Confidence 0.67 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.72
In conclusion, we demonstrate that various NSAIDs can activate the three families of MAP kinases and that this activation depends on the presence of reactive oxygenated species.
Positive_regulation (activate) of MAP associated with cinod
9) Confidence 0.67 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.36 Pain Relevance 0.87
Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases.
Positive_regulation (activation) of MAP associated with inflammation and cinod
10) Confidence 0.67 Published 2008 Journal Cell. Signal. Section Title Doc Link 18374541 Disease Relevance 0.48 Pain Relevance 0.53
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Positive_regulation (activation) of MAP associated with kinase c, nicotine and apoptosis
11) Confidence 0.67 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.13 Pain Relevance 0.60
The time profile-concentration changes of increased MAP and renin-aldosterone suggests a cause-effect relationship.
Positive_regulation (increased) of MAP
12) Confidence 0.67 Published 1996 Journal Br J Anaesth Section Abstract Doc Link 8688262 Disease Relevance 0.44 Pain Relevance 0.16
The orotracheal intubation caused significant increases in SBP, DBP, MAP, and RPP in these two groups in comparision with postinduction values (P < 0.05), but these hemodynamic changes lasted only 1 to 2 minutes and then decreased gradually to the postinduction level.
Positive_regulation (increases) of MAP
13) Confidence 0.67 Published 2007 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 18051724 Disease Relevance 0 Pain Relevance 0
FGF-2 rapidly induced activation of ERK1/2 and p38 MAP kinases, and specific inhibitors for these enzymes significantly reduced FGF-2-induced IL-6 release.
Positive_regulation (activation) of MAP
14) Confidence 0.67 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
From these results, we conclude that NSAIDs can induce prolonged activation of MAP kinases in colon cancer cells and that, of these, p38 MAP kinase may play a partial but significant role in indomethacin-induced apoptosis.
Positive_regulation (activation) of MAP in colon associated with colon cancer, cinod and apoptosis
15) Confidence 0.49 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11459290 Disease Relevance 0.99 Pain Relevance 0.31
The importance of activated MAP kinases for DOR internalization is further demonstrated by glutamate and paclitaxel because these substances induce phosphorylation of ERK1/2 and concomitantly prevent DOR sequestration by etorphine.
Positive_regulation (activated) of MAP associated with glutamate and immobilon
16) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.95
In addition, receptor internalization by morphine was facilitated by inhibition of protein kinase C and opioid-mediated transactivation of epidermal growth factor receptor (EGFR), both activating ERK/MAP kinases by opioids.
Positive_regulation (transactivation) of MAP associated with kinase c, opioid and morphine
17) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 1.09
The activation of MAP kinases by H(2)O(2) and NSAIDs was suppressed by quinone reductase inhibitors, suggesting that "redox cycling" was involved in the activation mechanisms of MAP kinases by H(2)O(2) and NSAIDs.
Positive_regulation (activation) of MAP associated with cinod
18) Confidence 0.49 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.46 Pain Relevance 0.94
In breast cancer cells TGFbeta appears to stimulate PTHrP secretion by a posttranscriptional mechanism through both Smad and p38 mitogen activated protein (MAP) kinase signaling pathways.
Positive_regulation (activated) of MAP associated with breast cancer
19) Confidence 0.49 Published 2000 Journal Crit. Rev. Eukaryot. Gene Expr. Section Abstract Doc Link 11186331 Disease Relevance 1.73 Pain Relevance 0
Activation of spinal cord mitogen-activated protein (MAP) kinases, which are essential for the hyperalgesia following injury or incision and occur in both neurons and glia, is inhibited by spinal local anesthetics.
Positive_regulation (Activation) of MAP in spinal associated with hyperalgesia, injury, local anesthetic and spinal cord
20) Confidence 0.49 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087121 Disease Relevance 0.58 Pain Relevance 1.64

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