INT46843

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Context Info
Confidence 0.47
First Reported 1982
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 3.45
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Trf) transport (Trf) mitochondrion (Trf)
extracellular space (Trf) extracellular region (Trf) cytoplasmic membrane-bounded vesicle (Trf)
Anatomy Link Frequency
plasma 2
bone marrow 2
tail 1
Trf (Mus musculus)
Pain Link Frequency Relevance Heat
tail-flick 1 96.56 Very High Very High Very High
Inflammation 40 95.32 Very High Very High Very High
Pain 4 68.44 Quite High
chest pain 2 50.92 Quite High
headache 6 50.40 Quite High
Spinal cord 2 48.00 Quite Low
cva 1 43.20 Quite Low
Angina 1 28.32 Quite Low
antagonist 1 27.96 Quite Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 97.64 Very High Very High Very High
Coronary Artery Disease 17 97.28 Very High Very High Very High
INFLAMMATION 44 95.32 Very High Very High Very High
Iron-deficiency Anemia 4 94.32 High High
Hyperlipoproteinemia Type Ii 66 89.96 High High
Hyperlipidemia 19 89.60 High High
Anaemia 16 88.16 High High
Thalassemia 2 85.20 High High
Chronic Renal Failure 5 82.40 Quite High
Body Weight 3 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 20 normal subjects 99mTC-RBCs were compared with 113mIn which binds to transferrin after IV injection.
transferrin Binding (binds) of
1) Confidence 0.47 Published 1982 Journal Eur J Nucl Med Section Abstract Doc Link 7128630 Disease Relevance 0.33 Pain Relevance 0
Loperamide-loaded HSA nanoparticles with covalently bound transferrin or the OX26 or R17217 antibodies induced significant anti-nociceptive effects in the tail-flick test in ICR (CD-1) mice after intravenous injection, demonstrating that transferrin or these antibodies covalently coupled to HSA nanoparticles are able to transport loperamide and possibly other drugs across the BBB.
transferrin Binding (bound) of in tail associated with nociception and tail-flick
2) Confidence 0.33 Published 2009 Journal Eur J Pharm Biopharm Section Abstract Doc Link 18805484 Disease Relevance 0.10 Pain Relevance 0.05
Nonetheless, we observed that, similar to control ScGT1 cells, Tfn could not be detected inside the cells after a 45 minutes chase period (compare panels c and d in Figure 3), indicating that under these conditions Tfn recycling to the surface via EEs was unaffected.
Tfn Binding (recycling) of
3) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Conjugation of transferrin to polyethyleneimine has further been shown to enhance transfection efficiency, likely via enhanced endocytosis (48).
transferrin Binding (Conjugation) of
4) Confidence 0.10 Published 2006 Journal Biol Proced Online Section Body Doc Link PMC1489265 Disease Relevance 0.08 Pain Relevance 0
Ferric carboxymaltose is a macromolecular ferric hydroxide carbohydrate complex, which allows for controlled delivery of iron within the cells of the reticuloendothelial system and subsequent delivery to the iron-binding proteins ferritin and transferrin, with minimal risk of release of large amounts of ionic iron in the serum.
transferrin Binding (iron-binding) of
5) Confidence 0.09 Published 2009 Journal Drugs Section Abstract Doc Link 19405553 Disease Relevance 0.63 Pain Relevance 0.04
The strategy of this approach was based on the ability of the fusion protein to be capable of binding both plasma LDL and the cellular transferrin receptor.
transferrin Binding (binding) of in plasma
6) Confidence 0.06 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.18 Pain Relevance 0
Sequestration of the scarce quantities of soluble iron is a prototypical protective response against invading bacteria, mediated by the iron-binding proteins transferrin and lactoferrin and the storage protein ferritin.
transferrin Binding (binding) of
7) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0 Pain Relevance 0
The clinical assessment of iron stores relied on the determination of serum iron, total iron-binding capacity and percent transferrin or direct examination of bone marrow [10].
transferrin Spec (examination) Binding (capacity) of in bone marrow
8) Confidence 0.04 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2713944 Disease Relevance 0.61 Pain Relevance 0.15
Historically the clinical assessment of iron stores has relied on the determination of serum iron, total iron-binding capacity and percent transferrin or direct examination of bone marrow.
transferrin Spec (examination) Binding (capacity) of in bone marrow
9) Confidence 0.04 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2713944 Disease Relevance 0.28 Pain Relevance 0.05
Antioxidants attenuate ROS by binding to transition metal-containing proteins, transferrin or ceruloplasmin, inhibiting cellular reactions (Vitamin E) and detoxifying ROS and RNS, (GSH, SODs, catalase) [108].


transferrin Binding (binding) of
10) Confidence 0.03 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.50 Pain Relevance 0
There were weak negative associations of haemoglobin with mean cell volume and mean cell haemoglobin concentration, strong negative associations with proportional reticulocyte counts, oxygen affinity, plasma volume, serum transferrin receptors, and erythropoietin levels and strong positive associations with red cell mass.
transferrin Neg (negative) Binding (associations) of in plasma
11) Confidence 0.02 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8562387 Disease Relevance 0.75 Pain Relevance 0.07
It may also act as magnesium-binding, iron-binding or metal-binding protein.
metal-binding protein Binding (binding) of
12) Confidence 0.01 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586131 Disease Relevance 0 Pain Relevance 0

General Comments

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