INT46848

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.01
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TPX2) mitosis (TPX2) nucleolus (TPX2)
nucleus (TPX2) cell cycle (TPX2) cell division (TPX2)
TPX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 285 100.00 Very High Very High Very High
cINOD 16 93.44 High High
COX-2 inhibitor 15 85.72 High High
Multiple sclerosis 28 84.64 Quite High
cytokine 22 84.04 Quite High
anesthesia 1 82.00 Quite High
lidocaine 1 79.68 Quite High
alcohol 2 71.76 Quite High
headache 2 66.88 Quite High
antagonist 10 49.36 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 285 100.00 Very High Very High Very High
Death 49 100.00 Very High Very High Very High
Apoptosis 143 97.08 Very High Very High Very High
INFLAMMATION 28 92.00 High High
Necrosis 9 85.36 High High
Cancer 27 85.00 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 215 84.88 Quite High
Demyelinating Disease 32 84.64 Quite High
Asthma 1 82.72 Quite High
Adhesions 75 74.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 9 of the 13 subjects tested, inhaled histamine significantly increased P100.
Positive_regulation (increased) of P100
1) Confidence 0.70 Published 1982 Journal J Appl Physiol Section Abstract Doc Link 7129991 Disease Relevance 0.08 Pain Relevance 0.16
Almost all incidences were of mild or moderate severity and transient, and only 8.5% of patients were experiencing FLS at the 96-week visit.
Positive_regulation (experiencing) of FLS
2) Confidence 0.10 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875722 Disease Relevance 0.30 Pain Relevance 0.41
There was no clinically meaningful change from baseline in the score for the FLS component of the MSTCQ in either treatment group, indicating that FLS are not an obstacle in the transition to the new formulation of sc IFN beta-1a, and that any FLS that occur during transition can be easily managed with ibuprofen taken either preventatively or PRN.
Positive_regulation (occur) of FLS
3) Confidence 0.10 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875722 Disease Relevance 0.22 Pain Relevance 0.11
This study also showed that human RA FLS treated with diosgenin became rounder, shrank, and became separated from adjacent cells.
Positive_regulation (treated) of RA FLS associated with rheumatoid arthritis
4) Confidence 0.08 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 1.37 Pain Relevance 0.18
Although the excess endogenous production of PGE2 appears to be associated with the induction of RA FLS death, the exact mechanism by which this compound brings about this phenomenon remains to be elucidated.


Positive_regulation (induction) of RA FLS associated with rheumatoid arthritis and death
5) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 1.01 Pain Relevance 0.24
RA FLS death induced by diosgenin was quantified by the determination of cytoplasmic histone-associated DNA fragments.
Positive_regulation (induced) of RA FLS associated with rheumatoid arthritis and death
6) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 1.53 Pain Relevance 0.22
FLs perceptions of ART were characterised by ambivalence.
Positive_regulation (perceptions) of FLs
7) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2916904 Disease Relevance 0.21 Pain Relevance 0.04
The impact of banning TH's activities on the demand of spiritual services deserves further attention as THs and FLs are consulted for similar reasons and share an economic context of severe deprivation.
Positive_regulation (consulted) of FLs
8) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2916904 Disease Relevance 0.16 Pain Relevance 0
To investigate the effect of adrenomedullin, we incubated FLS at RT for 1 hour with adrenomedullin at indicated concentrations.
Positive_regulation (incubated) of FLS
9) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.14 Pain Relevance 0

General Comments

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