INT46898

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Context Info
Confidence 0.29
First Reported 1982
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1 99.32 Very High Very High Very High
Paracetamol 17 99.16 Very High Very High Very High
Analgesic 1 68.48 Quite High
Disease Link Frequency Relevance Heat
Injury 5 81.04 Quite High
Death 1 72.64 Quite High
Necrosis 1 71.36 Quite High
Hepatotoxicity 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 30% decrease in cytochromes P-450 induced by cobalt chloride failed to provide protection against APAP lethality.
Negative_regulation (decrease) of Positive_regulation (induced) of cytochromes P-450 associated with paracetamol
1) Confidence 0.29 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.36 Pain Relevance 1.07
Intraperitoneal administration of 9-hydroxyellipticine, a specific cytochrome P-448 inhibitor, inhibited 3-methylcholanthrene-induced cytochrome P-448 activity (ethoxyresorufin O-deethylase, biphenyl 2-hydroxylase) and formation of the safrole carbene ligand complex with this cytochrome, but did not inhibit phenobarbital-induced cytochrome P-450 activity (ethyl-morphine N-demethylase) or formation of the safrole carbene ligand complex with this cytochrome.
Negative_regulation (inhibit) of Positive_regulation (induced) of P-450 associated with morphine
2) Confidence 0.17 Published 1982 Journal Chem. Biol. Interact. Section Abstract Doc Link 7151231 Disease Relevance 0 Pain Relevance 0.10

General Comments

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