INT46902

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Context Info
Confidence 0.16
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.90
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ociad1) mitochondrion (Ociad1)
Anatomy Link Frequency
macrophages 1
nerve 1
TMJ 1
brain 1
microglia 1
Ociad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
allodynia 2 99.76 Very High Very High Very High
Serotonin 1 99.48 Very High Very High Very High
Rostral ventromedial medulla 3 99.00 Very High Very High Very High
Inflammation 8 98.94 Very High Very High Very High
Snapping jaw 8 98.68 Very High Very High Very High
Locus ceruleus 3 97.48 Very High Very High Very High
spinal dorsal horn 2 88.00 High High
Pain 3 87.08 High High
Spinal nerve ligature 2 85.08 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 99.76 Very High Very High Very High
INFLAMMATION 6 98.94 Very High Very High Very High
Temporomandibular Joint Syndrome 8 98.68 Very High Very High Very High
Pain 3 87.08 High High
Headache 1 58.28 Quite High
Gastrointestinal Disease 1 57.76 Quite High
Frailty 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The administration of drugs such as p-chlorophenylalanine (PCPA), 5,6-dihydroxytryptamine (5,6-DHT) and fenfluramine that lower the striatal and hypothalamic serotonin (5-HT) content caused an increase in Met-enkephalin-like immunoreactive material (ME-IR) in these brain areas.
Positive_regulation (increase) of Met-enkephalin-like immunoreactive material in brain associated with enkephalin and serotonin
1) Confidence 0.16 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7151862 Disease Relevance 0 Pain Relevance 0.15
The results showed that 10-day persistent TMJ inflammation (induced by CFA) alone did not induce a significant increase in Fos-like immunoreactive (Fos-LI) neurons in the rostral ventromedial medulla (RVM) or locus coeruleus (LC), but that formalin injection of the masseter muscle or hindpaw induced a significant increase in Fos-LI neurons in the RVM and LC of rats with and without TMJ inflammation (P < 0.05).
Positive_regulation (increase) of immunoreactive in TMJ associated with snapping jaw, inflammation, locus ceruleus and rostral ventromedial medulla
2) Confidence 0.13 Published 2006 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 16944837 Disease Relevance 1.20 Pain Relevance 1.36
The increase of pNR1-immunoreactive neurons in the NG was observed only at 28 days after the nerve ligation.
Positive_regulation (increase) of pNR1-immunoreactive in nerve
3) Confidence 0.09 Published 2005 Journal Pain Section Abstract Doc Link 15936881 Disease Relevance 0.58 Pain Relevance 0.93
The accumulation of ED1-immunoreactive microglia/macrophages at the lesion was similar in treated and control rats.
Positive_regulation (accumulation) of ED1-immunoreactive in microglia
4) Confidence 0.04 Published 2009 Journal J Neurosurg Spine Section Body Doc Link 19929361 Disease Relevance 0 Pain Relevance 0
The accumulation of ED1-immunoreactive microglia/macrophages at the lesion was similar in treated and control rats.
Positive_regulation (accumulation) of ED1-immunoreactive in macrophages
5) Confidence 0.01 Published 2009 Journal J Neurosurg Spine Section Body Doc Link 19929361 Disease Relevance 0 Pain Relevance 0
Immunoblot analyses showed that methanol extract increased the levels of CYP1A1, CYP1A2, CYP2B-, and GSTYb-immunoreactive proteins.
Positive_regulation (increased) of GSTYb-immunoreactive
6) Confidence 0.00 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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