INT4697

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Context Info
Confidence 0.61
First Reported 1976
Last Reported 2008
Negated 3
Speculated 2
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 17.32
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
B18 6
B65 6
B35 2
T cells 2
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 94 100.00 Very High Very High Very High
Inflammation 114 99.56 Very High Very High Very High
cytokine 52 98.76 Very High Very High Very High
Arthritis 86 95.84 Very High Very High Very High
Pain 4 87.24 High High
rheumatoid arthritis 11 86.40 High High
agonist 2 81.16 Quite High
tramadol 1 75.28 Quite High
bradykinin 24 75.04 Quite High
antagonist 8 67.08 Quite High
Disease Link Frequency Relevance Heat
Chlamydia Infection 265 100.00 Very High Very High Very High
Low Back Pain 85 100.00 Very High Very High Very High
Seronegative Spondarthritis 47 100.00 Very High Very High Very High
Sacroiliitis 2 100.00 Very High Very High Very High
Sprains And Strains 2 99.96 Very High Very High Very High
INFLAMMATION 90 99.56 Very High Very High Very High
Targeted Disruption 39 99.56 Very High Very High Very High
Disease 244 99.04 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 83 99.00 Very High Very High Very High
Disease Susceptibility 2 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies from animal models have demonstrated that HLA-B27 overexpression can cause inflammatory disease with spondyloarthritis features, and together with investigations of patient-derived material, both innate adaptive and immune responses have been implicated.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HLA-B27 associated with inflammation and disease
1) Confidence 0.61 Published 2006 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 16777583 Disease Relevance 0.51 Pain Relevance 0.26
Hbeta(2)m can form a stable complex with HLA-B27 and may stabilize and enhance the expression of HLA-B2704 on the cell surface.


Spec (may) Positive_regulation (enhance) of Gene_expression (expression) of HLA-B2704
2) Confidence 0.60 Published 2002 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 11955421 Disease Relevance 0.07 Pain Relevance 0
Out of 52 Hardy-Weinberg analyses (26 analyses of controls and 26 of cases), three resulted in disequilibrium at p < 0.05, as expected by chance: HLA-B39 controls, HLA-B51 cases and HLA-B65 cases, each due to a single homozygote of a relatively rare allele.
Positive_regulation (chance) of Gene_expression (cases) of HLA-B51 in B65
3) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.18 Pain Relevance 0
Out of 52 Hardy-Weinberg analyses (26 analyses of controls and 26 of cases), three resulted in disequilibrium at p < 0.05, as expected by chance: HLA-B39 controls, HLA-B51 cases and HLA-B65 cases, each due to a single homozygote of a relatively rare allele.
Positive_regulation (chance) of Gene_expression (cases) of HLA-B65 in B65
4) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.18 Pain Relevance 0
Among the 111 healthy controls, 80% presented HLA-B 2,705, followed by HLA-B 2,702 in 10%, HLA-B 2,703 in 6%, HLA-B 2,707 in 3% and HLA-B 2,713 in 1%.
Positive_regulation (presented) of Gene_expression (presented) of HLA-B
5) Confidence 0.49 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 17717670 Disease Relevance 1.03 Pain Relevance 0.55
No significant overlap of HLA-B27 was observed with the ER-resident chaperone calreticulin (not shown).
Neg (No) Positive_regulation (overlap) of Neg (No) Gene_expression (overlap) of HLA-B27
6) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0 Pain Relevance 0
The finding in our study that the frequency of the HLA-B35 allele was increased in Korean children with Kawasaki disease suggests a role for infection in Kawasaki disease.
Positive_regulation (increased) of Gene_expression (frequency) of HLA-B35 allele in B35 associated with mucocutaneous lymph node syndrome and infection
7) Confidence 0.48 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 1.56 Pain Relevance 0
Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis.
Positive_regulation (Determination) of Gene_expression (Determination) of HLA-B27 associated with spinal inflammation
8) Confidence 0.46 Published 2008 Journal Iran J Allergy Asthma Immunol Section Title Doc Link 18322308 Disease Relevance 0.66 Pain Relevance 0.57
[Andersson's phenomenon in HLA-B27 negative ankylosing spondylitis].
Positive_regulation (phenomenon) of Gene_expression (ankylosing) of HLA-B27 associated with spinal inflammation
9) Confidence 0.45 Published 1990 Journal Minerva Med. Section Title Doc Link 2234475 Disease Relevance 0.20 Pain Relevance 0.20
[Andersson's phenomenon in HLA-B27 negative ankylosing spondylitis].
Positive_regulation (phenomenon) of Neg (negative) Gene_expression (negative) of HLA-B27 associated with spinal inflammation
10) Confidence 0.45 Published 1990 Journal Minerva Med. Section Title Doc Link 2234475 Disease Relevance 0.19 Pain Relevance 0.19
Initial work in our laboratory has resulted in the production of probes with specificity for HLA-B locus genes and current efforts are directed toward the derivation of B27 allele-specific probes.
Positive_regulation (resulted) of Gene_expression (production) of HLA-B
11) Confidence 0.45 Published 1985 Journal Immunol. Rev. Section Abstract Doc Link 2412952 Disease Relevance 0.52 Pain Relevance 0.06
Studies from animal models have demonstrated that HLA-B27 overexpression can cause inflammatory disease with spondyloarthritis features, and together with investigations of patient-derived material, both innate adaptive and immune responses have been implicated.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HLA-B27 associated with inflammation and disease
12) Confidence 0.44 Published 2006 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 16777583 Disease Relevance 0.51 Pain Relevance 0.26
Out of 52 Hardy-Weinberg analyses (26 analyses of controls and 26 of cases), three resulted in disequilibrium at p < 0.05, as expected by chance: HLA-B39 controls, HLA-B51 cases and HLA-B65 cases, each due to a single homozygote of a relatively rare allele.
Positive_regulation (chance) of Gene_expression (controls) of HLA-B39 in B65
13) Confidence 0.44 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.18 Pain Relevance 0
[Standardization and automation of HLA B27 typing by flow cytometry: validation and comparison with microlymphocytotoxicity].
Positive_regulation (automation) of Gene_expression (typing) of HLA B27 associated with seronegative spondarthritis
14) Confidence 0.43 Published 2000 Journal Ann. Biol. Clin. (Paris) Section Title Doc Link 10932047 Disease Relevance 0.45 Pain Relevance 0.18
Generating HLA-B27/Chlamydia peptide tetramers
Positive_regulation (Generating) of Gene_expression (tetramers) of HLA-B27/Chlamydia associated with chlamydia infection
15) Confidence 0.40 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.64 Pain Relevance 0.09
Generating HLA-B27/Chlamydia peptide tetramers
Positive_regulation (tetramers) of Gene_expression (tetramers) of HLA-B27/Chlamydia associated with chlamydia infection
16) Confidence 0.40 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.64 Pain Relevance 0.09
Generation of antigen-specific CD8+ T cell lines after MACS sorting of HLA-B27 tetramer-positive T cells
Positive_regulation (Generation) of Gene_expression (lines) of HLA-B27 tetramer in T cells
17) Confidence 0.40 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.44 Pain Relevance 0.03
The increase detected in HLA-B27 surface expression (Figure 1d) therefore occurred despite the cDNA being under a non-endogenous (CMV) promoter.
Positive_regulation (increase) of Gene_expression (expression) of HLA-B27 associated with cytomegalovirus infection
18) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.10 Pain Relevance 0
For further validation of the significance of increased HLA-B27 mRNA expression in AS patients, extended experiments were conducted in another 10 patients with definite AS possessing HLA-B27/B60 (B*40012).
Positive_regulation (increased) of Gene_expression (expression) of HLA-B27
19) Confidence 0.37 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16755659 Disease Relevance 0.15 Pain Relevance 0
For further validation of the significance of increased HLA-B27 mRNA expression in AS patients, extended experiments were conducted in another 10 patients with definite AS possessing HLA-B27/B60 (B*40012).
Positive_regulation (conducted) of Gene_expression (expression) of HLA-B27
20) Confidence 0.37 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16755659 Disease Relevance 0.15 Pain Relevance 0

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