INT47011

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Context Info
Confidence 0.44
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.93
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gusb) endoplasmic reticulum (Gusb) carbohydrate metabolic process (Gusb)
lysosome (Gusb)
Anatomy Link Frequency
brain 2
macrophages 1
periventricular nuclei 1
anterior 1
amygdala 1
Gusb (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 18 99.86 Very High Very High Very High
isoflurane 3 99.68 Very High Very High Very High
depression 111 95.80 Very High Very High Very High
Inflammation 65 95.24 Very High Very High Very High
Pain 19 94.84 High High
amygdala 3 93.08 High High
Central nervous system 24 91.52 High High
nud 7 89.96 High High
Multiple sclerosis 15 89.92 High High
Angina 1 87.04 High High
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 135 100.00 Very High Very High Very High
Syndrome 80 100.00 Very High Very High Very High
Injury 71 99.66 Very High Very High Very High
Congenital Anomalies 2 97.92 Very High Very High Very High
Phobia 42 97.28 Very High Very High Very High
Lysosome Storage Disease 8 96.92 Very High Very High Very High
Depression 115 95.80 Very High Very High Very High
Pressure Volume 2 Under Development 3 95.48 Very High Very High Very High
Infection 75 95.28 Very High Very High Very High
INFLAMMATION 77 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All drugs significantly increased GUR in the dorsal medullary nuclei, whereas the drugs decreased it in the n. tegmenti ventralis, substantia reticularis mesencephali, some hypothalamic periventricular nuclei, amygdala nuclei, and n. accumbens septi.
Positive_regulation (increased) of GUR in periventricular nuclei associated with amygdala
1) Confidence 0.44 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7176220 Disease Relevance 0.26 Pain Relevance 0.29
Clonidine alone increased GUR in medullary reticular nuclei and decreased it in the infundibulum, n. proprius striae terminalis and cortex entorhinalis. alpha-Methyldopa (but not other drugs) increased GUR in the n. reticularis parvocellularis and decreased it in the n. ambiguus, n. ventromedialis, area lateralis and anterior hypothalami, area preoptica medialis and n. medialis septi.
Positive_regulation (increased) of GUR in anterior associated with clonidine
2) Confidence 0.39 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7176220 Disease Relevance 0.23 Pain Relevance 0.40
Isoflurane produced a 50% increase of beta-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5.
Positive_regulation (increase) of beta-glucuronidase associated with isoflurane
3) Confidence 0.34 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9147027 Disease Relevance 0 Pain Relevance 0.28
Gus is a sensitive indicator LPS activation of macrophages.
Positive_regulation (activation) of Gus in macrophages
4) Confidence 0.30 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.44 Pain Relevance 0.11
Although the fine mechanisms underlying such "aberrant perceptions" are yet not fully clarified, it is thought that an altered activation of the gut-wall receptors, an altered conduction of sensory inputs at the level of neural pathways, or an impaired processing of the sensations at the level of brain, may occur along the brain-gut axis.
Positive_regulation (activation) of gut-wall in gut
5) Confidence 0.28 Published 2004 Journal Dig Liver Dis Section Abstract Doc Link 15248374 Disease Relevance 0.66 Pain Relevance 0.48
For PTSD at 6 months, ASD symptom severity at 2 weeks (ASDS) was forced into the regression in the first step and explained 43% of the variance, ?
Positive_regulation (forced) of ASD associated with post-traumatic stress disorder
6) Confidence 0.26 Published 2008 Journal J Consult Clin Psychol Section Body Doc Link PMC2672050 Disease Relevance 1.47 Pain Relevance 0.25
Therefore, the diagnosis of ASD in those with FXS may also be related to additional risks including genetic and environmental factors leading to additional brain dysfunction additive to the FMR1 mutation (Loesch et al. 2007).
Positive_regulation (related) of ASD in brain associated with syndrome
7) Confidence 0.24 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.61 Pain Relevance 0.17
In the first month after their child's injury, 12% of parents had ASD and another 25% had partial ASD.
Positive_regulation (had) of ASD associated with post-traumatic stress disorder and injury
8) Confidence 0.23 Published 2009 Journal J Trauma Stress Section Abstract Doc Link 19637323 Disease Relevance 1.79 Pain Relevance 0.07
Furthermore, pioglitazone can cross the BBB, [24] suggesting possible direct effects on brain physiology, which could positively influence possible abnormalities in regional brain glucose utilization [25] or dysregulation of functional activity [26] as reported to occur ASD.
Positive_regulation (occur) of ASD in brain associated with congenital anomalies
9) Confidence 0.23 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.75 Pain Relevance 0.37
-glucoronidase (GUSB) with consequent accumulation of glycosaminoglycans (GAGs) affecting a number of organ systems.
Positive_regulation (accumulation) of GUSB in organ systems
10) Confidence 0.18 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.04 Pain Relevance 0.12
All drugs significantly increased GUR in the dorsal medullary nuclei, whereas the drugs decreased it in the n. tegmenti ventralis, substantia reticularis mesencephali, some hypothalamic periventricular nuclei, amygdala nuclei, and n. accumbens septi.
Positive_regulation (increased) of GUR in amygdala associated with amygdala
11) Confidence 0.15 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7176220 Disease Relevance 0.26 Pain Relevance 0.29
1) induced a strong GUS activity whereas no induction was observed with the ethanol-soluble fraction (Figure 1(c)).
Neg (no) Positive_regulation (induction) of GUS
12) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2860583 Disease Relevance 0.18 Pain Relevance 0
1) induced a strong GUS activity whereas no induction was observed with the ethanol-soluble fraction (Figure 1(c)).
Positive_regulation (induced) of GUS
13) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2860583 Disease Relevance 0.18 Pain Relevance 0
We cannot exclude that other than the evaluated fusion techniques indeed promote ASD.
Positive_regulation (promote) of ASD
14) Confidence 0.02 Published 2003 Journal German Medical Science : GMS e-journal Section Body Doc Link PMC2703223 Disease Relevance 0.07 Pain Relevance 0.04

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