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Context Info
Confidence 0.53
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.52
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (PNPLA4) cellular_component (PNPLA4) biological_process (PNPLA4)
Anatomy Link Frequency
kidney 1
PNPLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 7 98.96 Very High Very High Very High
cINOD 4 93.84 High High
cva 3 83.52 Quite High
ischemia 7 82.40 Quite High
guanethidine 1 65.44 Quite High
Pain 3 61.28 Quite High
Calcium channel 6 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 21 98.62 Very High Very High Very High
Myocardial Infarction 13 87.92 High High
Cv General 3 Under Development 3 83.52 Quite High
Cv Unclassified Under Development 5 82.40 Quite High
Atherosclerosis 4 81.00 Quite High
Necrosis 3 77.60 Quite High
Cardiovascular Disease 3 75.00 Quite High
Arrhythmias 2 Under Development 1 75.00 Quite High
Heart Disease 2 70.00 Quite High
Attention Deficit Hyperactivity Disorder 2 64.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latter comprises activation of lipid peroxidation, activation of phospholipases, and the detergentlike action of excessive amounts of free fatty acids and lysophospholipids.
Positive_regulation (activation) of phospholipases
1) Confidence 0.53 Published 1982 Journal Basic Res. Cardiol. Section Abstract Doc Link 7181828 Disease Relevance 0.17 Pain Relevance 0.13
Adrenergic actions can also cause the abnormal lipid metabolism that is associated with CAD and IsHD by catecholamine-induced metabolic actions on lipid mobilization by activation of phospholipases.
Positive_regulation (activation) of phospholipases associated with coronary artery disease and catecholamine
2) Confidence 0.06 Published 2004 Journal Am J Ther Section Abstract Doc Link 15356432 Disease Relevance 2.24 Pain Relevance 0.25
LPA has multiple cellular effects, including the stimulation of phospholipases, the mobilization of [Ca2+]i, and the inhibition of adenylate cyclase (12).
Positive_regulation (stimulation) of phospholipases
3) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0 Pain Relevance 0
Thus, this study suggests that indomethacin induces impairment in structure and function of BBM in the kidney, with these effects possibly mediated by free radicals and activation of phospholipases.
Positive_regulation (activation) of phospholipases in kidney
4) Confidence 0.00 Published 2005 Journal Arch. Toxicol. Section Abstract Doc Link 15889237 Disease Relevance 0.12 Pain Relevance 0.15

General Comments

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