INT47027

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Context Info
Confidence 0.50
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.32
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BCHE) extracellular region (BCHE) endoplasmic reticulum (BCHE)
enzyme binding (BCHE)
Anatomy Link Frequency
central nervous system 1
cortex 1
BCHE (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
Central nervous system 6 99.68 Very High Very High Very High
Nicotine 8 98.48 Very High Very High Very High
addiction 1 98.22 Very High Very High Very High
anticonvulsant 3 79.48 Quite High
epidural 1 79.04 Quite High
monoamine 1 77.20 Quite High
Dopamine 2 72.64 Quite High
anesthesia 4 63.20 Quite High
Pain 2 61.36 Quite High
Disease Link Frequency Relevance Heat
Disease 189 99.24 Very High Very High Very High
Paralysis 2 97.56 Very High Very High Very High
Hallucination 4 94.36 High High
Amyloid Plaque 9 89.72 High High
Amnesia 1 89.08 High High
Neurodegenerative Disease 10 87.40 High High
Aggression 2 71.44 Quite High
Attention Deficit Hyperactivity Disorder 1 67.88 Quite High
Cognitive Disorder 40 65.48 Quite High
Pain 2 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, cholinesterase inhibitors increase assayed acetylcholine by two mechanisms, protection of hydrolysis and stimulation of facilitatory nicotine receptors.
Positive_regulation (increase) of cholinesterase associated with nicotine
1) Confidence 0.50 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11521162 Disease Relevance 0 Pain Relevance 0.32
The history suggested that the patient had pseudocholinesterase deficiency, an inherited condition in which patients remain paralyzed for a prolonged period after the use of succinylcholine.
Positive_regulation (had) of pseudocholinesterase associated with paralysis
2) Confidence 0.49 Published 2000 Journal Journal of Medical Internet Research Section Body Doc Link PMC1761855 Disease Relevance 0.10 Pain Relevance 0.12
Therefore, many therapeutic strategies to augment cerebral concentration of acetylcholine such as cholinergic precursors, cholinergic receptor agonists, cholinesterase inhibitors and acetylcholine release modulators have been evaluated in Alzheimer's disease.
Positive_regulation (augment) of cholinesterase associated with agonist and disease
3) Confidence 0.43 Published 1997 Journal Indian J. Exp. Biol. Section Abstract Doc Link 9567741 Disease Relevance 0.88 Pain Relevance 0.11
Environmental stimulation produces changes including expansion of visual cortex, increases in dendritic branching, glia and cholinesterase.
Positive_regulation (increases) of cholinesterase in cortex
4) Confidence 0.41 Published 1982 Journal Int Rehabil Med Section Abstract Doc Link 7183588 Disease Relevance 0.23 Pain Relevance 0.34
Butyrylcholinesterase is widely distributed in the central nervous system and may play a role in cholinergic function and neurodegeneration [29].
Positive_regulation (distributed) of Butyrylcholinesterase in central nervous system associated with central nervous system
5) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 0.25 Pain Relevance 0.11
Because of the dependence of REM sleep on the integrity of the cholinergic system, theoretically, one may predict increased REM sleep in cholinesterase inhibitor-treated AD patients [90].
Positive_regulation (increased) of cholinesterase associated with addiction and disease
6) Confidence 0.21 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.86 Pain Relevance 0.09

General Comments

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