INT47039

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 20
Disease Relevance 7.44
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SFRP1) extracellular space (SFRP1) extracellular region (SFRP1)
proteinaceous extracellular matrix (SFRP1) plasma membrane (SFRP1) intracellular (SFRP1)
Anatomy Link Frequency
muscles 3
external 2
lumbar region 1
ligaments 1
spine 1
SFRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 8 99.80 Very High Very High Very High
lumbar region 48 96.80 Very High Very High Very High
Pain 90 82.24 Quite High
cINOD 1 57.20 Quite High
agonist 11 53.04 Quite High
backache 93 49.84 Quite Low
anesthesia 1 25.00 Low Low
Arthritis 2 13.96 Low Low
alcohol 16 5.00 Very Low Very Low Very Low
Lasting pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatigue 579 100.00 Very High Very High Very High
Cancer 26 100.00 Very High Very High Very High
Uterine Fibroids 72 99.04 Very High Very High Very High
Hypocapnia 5 98.98 Very High Very High Very High
Apoptosis 9 92.48 High High
Endometriosis (extended) 2 91.12 High High
Pain 45 82.24 Quite High
Dyspnea 1 75.00 Quite High
Anxiety Disorder 6 69.04 Quite High
Unconsciousness 9 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several factors, such as speed of execution and loading of the spine, have been shown to influence the FRP.
Regulation (influence) of FRP in spine
1) Confidence 0.62 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2850324 Disease Relevance 0.17 Pain Relevance 0.11
Speed effect on FRP onset and cessation angles is presented in Figure 4.
Regulation (effect) of FRP
2) Confidence 0.54 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2850324 Disease Relevance 0 Pain Relevance 0
Heightened load also had an effect on FRP onset and cessation by increasing both angles.
Regulation (effect) of FRP
3) Confidence 0.54 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2850324 Disease Relevance 0 Pain Relevance 0.07
However, loading conditions did not affect FRP cessation angle at both the L2 and L5 levels (Figure 4).
Neg (not) Regulation (affect) of FRP
4) Confidence 0.52 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.63 Pain Relevance 0
Sarti et al. [12] studied the effect of movement speed on the FRP parameters.
Regulation (effect) of FRP
5) Confidence 0.38 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.79 Pain Relevance 0
We found a significant effect of muscular fatigue on both FRP cessation and FRP onset angles for all muscles (Figure 3).
Regulation (effect) of FRP in muscles associated with fatigue
6) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.37 Pain Relevance 0
Finally, repetition of movement can also influence the FRP.
Regulation (influence) of FRP
7) Confidence 0.27 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2850324 Disease Relevance 0.39 Pain Relevance 0.23
The effect of increasing load on the cervical FRP, by raising EMG RMS values, was similar to what was initially described in the lumbar region [11,13].
Regulation (effect) of FRP in lumbar region associated with lumbar region
8) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2850324 Disease Relevance 0 Pain Relevance 0.05
The main objectives of this study were to assess the effect of load and speed on the cervical FRP, and to document its repeatability.
Regulation (effect) of FRP
9) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2850324 Disease Relevance 0 Pain Relevance 0
The addition of a load anterior to the trunk modified the FRP response.
Regulation (modified) of FRP in trunk
10) Confidence 0.23 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.12 Pain Relevance 0.03
We found a significant effect of muscular fatigue on both FRP cessation and FRP onset angles for all muscles (Figure 3).
Regulation (effect) of FRP in muscles associated with fatigue
11) Confidence 0.23 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.31 Pain Relevance 0
To independently assess the effect of fatigue on the FRP, lumbar ES fatigue was evoked according to the Sorenson protocol.
Regulation (effect) of FRP associated with fatigue
12) Confidence 0.20 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.86 Pain Relevance 0
An isometric test to induce fatigue prevented the possible effect of creep development in the spinal ligaments and, therefore, enabled us to solely assess the effect of fatigue on the FRP.
Regulation (effect) of FRP in ligaments associated with fatigue
13) Confidence 0.20 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.80 Pain Relevance 0
The results of this study suggest that the presence of fatigue of the ES muscles modifies the FRP.
Regulation (modifies) of FRP in muscles associated with fatigue
14) Confidence 0.20 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2259346 Disease Relevance 0.75 Pain Relevance 0
The results of the present study indicate that muscular fatigue of the lumbar ES modulates the FRP.
Regulation (modulates) of FRP associated with fatigue
15) Confidence 0.20 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.75 Pain Relevance 0
Wnt signaling was recently implicated in the pathogenesis of uterine fibroids where the secreted frizzled related protein 1 (sFRP1) mRNA [10] was found to be significantly elevated in the tumor, and regulated by estrogen treatment.
Regulation (regulated) of sFRP1 in uterine associated with uterine fibroids and cancer
16) Confidence 0.19 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.92 Pain Relevance 0
Intimately related to studying where in the network the FRP is regulated is the study of possible mechanisms present to modify the FRP temporarily or persistently, in order to accommodate external fluctuations.
Regulation (regulated) of FRP in external
17) Confidence 0.12 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0
WNT signals are context-dependently transduced to both pathways based on the expression profile of WNT, SFRP, WIF, DKK, Frizzled receptors, coreceptors, and the activity of intracellular WNT signaling regulators.
Regulation (regulators) of SFRP
18) Confidence 0.06 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17634527 Disease Relevance 0.15 Pain Relevance 0.08
Intimately related to studying where in the network the FRP is regulated is the study of possible mechanisms present to modify the FRP temporarily or persistently, in order to accommodate external fluctuations.
Spec (possible) Regulation (modify) of FRP in external
19) Confidence 0.05 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0
Hypocapnia prolonged the AVFRP (less than halothane), had no effect on the AtFRP and shortened the AtERP.
Neg (no) Regulation (effect) of AtFRP associated with hypocapnia and halothane
20) Confidence 0.00 Published 1980 Journal Anesth. Analg. Section Abstract Doc Link 7191673 Disease Relevance 0.42 Pain Relevance 0.35

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