INT4704

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Context Info
Confidence 0.50
First Reported 1976
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.06
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 4 100.00 Very High Very High Very High
Clonidine 4 99.98 Very High Very High Very High
noradrenaline 21 99.78 Very High Very High Very High
agonist 3 99.78 Very High Very High Very High
Morphine 6 99.16 Very High Very High Very High
medulla 1 92.76 High High
Spinal cord 1 88.72 High High
antagonist 1 87.92 High High
Catechol-O-methyltransferase 1 86.00 High High
Hippocampus 1 82.44 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine was found to counteract the NA depletion induced by tyrosine hydroxylase inhibition in neonate rats, indicating that morphine reduces NA turnover.
Positive_regulation (induced) of Negative_regulation (inhibition) of tyrosine hydroxylase associated with noradrenaline and morphine
1) Confidence 0.50 Published 1982 Journal Med. Biol. Section Abstract Doc Link 6128445 Disease Relevance 0 Pain Relevance 1.22
Consistent with previous electrophysiological data, IBMX also accelerates the disappearance of NE after inhibition of tyrosine-3-monooxygenase.
Positive_regulation (accelerates) of Negative_regulation (inhibition) of tyrosine-3-monooxygenase
2) Confidence 0.46 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6194283 Disease Relevance 0.06 Pain Relevance 0.47
Whereas the alpha(2)-adrenoceptor agonist clonidine induced a similar reduction in tyrosine hydroxylase activity in the group subjected to the acute treatment and in the control group, it failed to do so after chronic clorgyline treatment.
Positive_regulation (induced) of Negative_regulation (reduction) of tyrosine hydroxylase associated with agonist and clonidine
3) Confidence 0.23 Published 2002 Journal Pharmacology Section Abstract Doc Link 11901301 Disease Relevance 0 Pain Relevance 0.40
Inhibition of tyrosine hydroxylase (by alpha-methyltyrosine) and of DA-beta-hydroxylase (by disulfiram or Ro 8-1981), in addition to the inhibition of tryptophan hydroxylase by PCPA, induced PGO waves comparable in density and temporal distribution to those occurring following the application of Ro 4-1284.
Positive_regulation (induced) of Negative_regulation (Inhibition) of tyrosine hydroxylase associated with dopamine
4) Confidence 0.02 Published 1976 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1275619 Disease Relevance 0 Pain Relevance 0.47

General Comments

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