INT47041

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Context Info
Confidence 0.44
First Reported 1980
Last Reported 2009
Negated 3
Speculated 1
Reported most in Body
Documents 8
Total Number 21
Disease Relevance 11.13
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
Apo (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 6 99.44 Very High Very High Very High
antagonist 3 95.56 Very High Very High Very High
Dopamine 1 95.12 Very High Very High Very High
qutenza 1 90.40 High High
Serotonin 1 85.76 High High
Catecholamine 12 82.00 Quite High
backache 1 79.44 Quite High
headache 1 77.44 Quite High
fluoxetine 1 72.32 Quite High
Angina 3 71.80 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 49 100.00 Very High Very High Very High
Hypothermia 7 99.96 Very High Very High Very High
Sprains And Strains 994 99.78 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

10 99.38 Very High Very High Very High
Repression 42 99.08 Very High Very High Very High
Shock 112 97.96 Very High Very High Very High
Obesity 97 95.72 Very High Very High Very High
Coronary Artery Disease 91 86.92 High High
Iron Overload 28 86.48 High High
Nicotine Addiction 4 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data suggest a role for apo A-IV and the CCK(1)R in PYY(3-36)-induced activation of the vagal afferent pathway and inhibition of gastric emptying, but this is likely not the pathway mediating the effects of PYY(3-36) on food intake.
Regulation (role) of apo associated with cholecystokinin
1) Confidence 0.44 Published 2007 Journal Endocrinology Section Abstract Doc Link 17641001 Disease Relevance 0.13 Pain Relevance 0.40
Clozapine and phenoxybenzamine, on the other hand, failed to modify APO hypothermia.
Neg (failed) Regulation (modify) of APO associated with hypothermia
2) Confidence 0.27 Published 1980 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 7192860 Disease Relevance 0.61 Pain Relevance 0.21
Moreover, the difference in sodB regulation between the two strains is not the result of a generalized difference in apo-Fur regulation between G27 and 26695 since the appropriate decrease in pfr expression [8] was observed in both strains under iron-limited growth and iron-depletion shock conditions (Fig 2A and 2B).
Regulation (regulation) of apo associated with shock and sprains and strains
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.41 Pain Relevance 0
There is no defined consensus sequence for apo-Fur binding given that the two promoters of the known apo-Fur regulated genes, pfr and sodB, share only minimal homology [1], [8].
Regulation (regulated) of apo
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.06 Pain Relevance 0
Therefore, we studied the impact of Lp(a)/apo(a) and other variables in subjects who had been under 60 years when they became cases.
Regulation (impact) of apo
5) Confidence 0.07 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9247362 Disease Relevance 0.91 Pain Relevance 0.10
The apo A-V is a highly responsive PPAR target gene [13].
Regulation (target) of apo
6) Confidence 0.06 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.93 Pain Relevance 0
The apo A-V is a highly responsive PPAR target gene [13].
Regulation (responsive) of apo
7) Confidence 0.06 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC545942 Disease Relevance 0.93 Pain Relevance 0
In keeping with this, some strains of H. pylori may have evolved to either inactivate apo-Fur regulation of sodB, or to weaken repression by decreasing the Fur/sodB binding affinity.
Regulation (regulation) of apo associated with repression and sprains and strains
8) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.38 Pain Relevance 0
Therefore, studies could potentially be designed with this strain that would allow for the determination of whether direct apo-Fur regulation of sodB provides a competitive advantage to H. pylori in vivo.
Spec (whether) Regulation (regulation) of apo associated with sprains and strains
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.40 Pain Relevance 0
Taken in total, these data indicate that apo-Fur regulation of sodB is altered in G27 as compared to 26695.


Regulation (regulation) of apo
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.59 Pain Relevance 0
However, apo-Fur regulation of pfr was as expected in all three strains (Fig. 4B and data not shown) [8].
Regulation (regulation) of apo associated with sprains and strains
11) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.97 Pain Relevance 0
Given the differences in sodB regulation in G27 and 26695, we wondered if other H. pylori strains exhibited apo-Fur regulation similar to G27 or 26695.
Regulation (regulation) of apo associated with sprains and strains
12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.78 Pain Relevance 0
Alteration of this nucleotide in G27 to that of 26695 restored apo-Fur dependent sodB regulation, indicating that a single base difference is at least partially responsible for the difference in sodB regulation observed among these H. pylori strains.
Regulation (regulation) of apo associated with sprains and strains
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671405 Disease Relevance 0.45 Pain Relevance 0
Expressing 26695 Fur in G27 (the “Fur swap” strain) did not restore apo-Fur sodB regulation in G27 under either iron-limited growth or iron-depletion shock conditions (Fig. 4A and data not shown).
Regulation (regulation) of apo associated with shock and sprains and strains
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.91 Pain Relevance 0
Herein we describe a series of experiments that define a single polymorphic nucleotide within the H. pylori sodB promoter that is important for apo-Fur dependent regulation.
Regulation (regulation) of apo
15) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.47 Pain Relevance 0
Future work from our group will focus on elucidating binding residues important for both iron-bound and apo-Fur regulation with the hope that continued exploration of Fur regulation will provide greater understanding into the complexity of gene regulation in this important human pathogen.



Regulation (regulation) of apo
16) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0 Pain Relevance 0
apo-Fur regulation has not been described for other bacterial species, and given that Fur plays a role in global gene regulation in response to environmental stressors and enhances the fitness of H. pylori as a pathogen, functional studies of Fur in H. pylori are of particular interest.
Regulation (regulation) of apo
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.43 Pain Relevance 0
Given this apo-regulation and since promoter activity can be measured by changes in fluorescence with our system, we expected to see a decrease in GFP fluorescence under iron limited conditions for both promoter fusions.
Regulation (regulation) of apo
18) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.21 Pain Relevance 0
In order to study apo-Fur dependent regulation in H. pylori, the sodB and pfr promoters from strain G27 were fused to the promoterless gpfmut3 gene in pTM117.
Regulation (regulation) of apo associated with sprains and strains
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.21 Pain Relevance 0
For instance, this correlation could also be a consequence of one or several differential expressed genes with independent effects on both apoB100 plasma levels (either by affecting synthesis in the liver or clearance in the periphery) and lipolysis in fat cells.
Neg (independent) Regulation (effects) of apoB100 in liver associated with obesity
20) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.78 Pain Relevance 0.07

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