INT47044

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.58
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ORM1) extracellular space (ORM1) extracellular region (ORM1)
Anatomy Link Frequency
plasma 2
ORM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 21 99.16 Very High Very High Very High
lidocaine 8 99.02 Very High Very High Very High
local anesthetic 45 98.82 Very High Very High Very High
fortral 4 98.32 Very High Very High Very High
Codeine 20 98.16 Very High Very High Very High
Morphine 29 97.48 Very High Very High Very High
Oxycodone 1 97.44 Very High Very High Very High
narcan 9 96.72 Very High Very High Very High
Paracetamol 25 92.80 High High
Opioid 63 92.00 High High
Disease Link Frequency Relevance Heat
Disease 2 98.88 Very High Very High Very High
Hypoxia 1 84.08 Quite High
Hypoventilation 2 81.88 Quite High
Respiratory Failure 14 79.04 Quite High
Sleep Disorders 11 75.60 Quite High
Pain 99 57.80 Quite High
Vomiting 18 52.84 Quite High
Overdose 2 42.48 Quite Low
Mydriatic 1 11.96 Low Low
Heart Rate Under Development 5 10.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, lidocaine and phenytoin demonstrated binding to this protein, and increases in the alpha-1 acid glycoprotein concentration produced decreases in the unbound (free) or "active" concentration of these two drugs.
Positive_regulation (increases) of alpha-1 acid glycoprotein associated with lidocaine
1) Confidence 0.68 Published 2004 Journal Ther Drug Monit Section Abstract Doc Link 14749548 Disease Relevance 0 Pain Relevance 0.50
Elevations of alpha 1-AGP that occur in a variety of diseases may alter the kinetic and pharmacologic activity of methadone.
Positive_regulation (Elevations) of alpha 1-AGP associated with methadone and disease
2) Confidence 0.28 Published 1981 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7193106 Disease Relevance 0.10 Pain Relevance 0.98
As the alpha 1-AGP increased from 0.05 to 2.0 gm/l, free fraction fell from 92.40% to 8.80%.
Positive_regulation (increased) of alpha 1-AGP
3) Confidence 0.28 Published 1981 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7193106 Disease Relevance 0 Pain Relevance 1.03
The experiments carried out in this study with different ligands (homologous saturated fatty acids, indomethacin and lidocaine) show that: 1. ligand hydrophobicity affects the run of the dependence between the free ligand fraction and its total concentration, which confirms the importance of the hydration layer in the drug binding process,2. similar anomalous changes of the free drug fraction are observed not only for drugs interacting with different binding sites on human serum albumin (HSA), i.e. for propofol and indomethacin, but also for basic local anesthetic lidocaine which is known to bind to other plasma protein, alpha-1-acid glycoprotein (AGP).Therefore, the increase of the free drug fraction at its low total concentration does not appear to be an exclusive feature of propofol-HSA system.
Positive_regulation (increase) of alpha-1-acid glycoprotein in plasma associated with addiction, lidocaine and local anesthetic
4) Confidence 0.21 Published 2008 Journal Eur J Pharm Sci Section Abstract Doc Link 18644440 Disease Relevance 0 Pain Relevance 0.33
Newborns and young infants less than 4–6 months of age also have increased free fraction of the drug in the blood because of decreased plasma protein (less alpha-1 acid glycoprotein and albumin) binding.
Positive_regulation (increased) of alpha-1 acid glycoprotein in plasma
5) Confidence 0.11 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004641 Disease Relevance 0.49 Pain Relevance 1.63

General Comments

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