INT47055

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Context Info
Confidence 0.75
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.85
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (RBP1) cytoplasm (RBP1)
Anatomy Link Frequency
liver 2
lymphocyte 1
nerve 1
astrocytes 1
body 1
RBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 62 97.56 Very High Very High Very High
Peripheral nerve injury 2 97.52 Very High Very High Very High
Inflammatory response 18 95.62 Very High Very High Very High
fibrosis 7 93.80 High High
cva 6 93.68 High High
Peripheral nervous system 6 91.12 High High
Neuropathic pain 2 85.88 High High
Spinal cord 32 81.84 Quite High
diabetic neuropathy 4 81.80 Quite High
headache 1 79.96 Quite High
Disease Link Frequency Relevance Heat
Injury 184 100.00 Very High Very High Very High
Burns 68 100.00 Very High Very High Very High
Liver Disease 62 99.92 Very High Very High Very High
Uterine Fibroids 120 99.84 Very High Very High Very High
Hepatitis 6 99.36 Very High Very High Very High
INFLAMMATION 83 97.56 Very High Very High Very High
Nervous System Injury 8 97.52 Very High Very High Very High
Sepsis 16 96.20 Very High Very High Very High
Wound Healing 116 94.44 High High
Rheumatoid Arthritis 80 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
nerve induced expression of the cellular retinol binding protein-I (CRBP-I) [25], which is implicated in
Gene_expression (expression) of CRBP-I in nerve
1) Confidence 0.75 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.34 Pain Relevance 0.18
Levels of retinol binding protein are reduced in hepatitis.
Gene_expression (Levels) of retinol binding protein associated with hepatitis
2) Confidence 0.57 Published 1982 Journal Gastroenterology Section Abstract Doc Link 7198070 Disease Relevance 1.00 Pain Relevance 0.13
qRT-PCR was used to examine the expression of GPNMB, RBP1, CAPG, APOE, TGFBI, and TIMP1, which were identified in the nonhuman primate model, in immuno-enriched optic nerve head astrocytes from glaucomatous Caucasian American donors [see Additional file 7 and Additional file 8].
Spec (examine) Gene_expression (expression) of RBP1 in astrocytes
3) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.54 Pain Relevance 0
8m ATRA treatment, the expression of the CRBP-1 in leiomyoma was similar to myometrial cells.
Gene_expression (expression) of CRBP-1 associated with uterine fibroids
4) Confidence 0.29 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.04 Pain Relevance 0
Early postoperative nutritional derangements, as reflected by the levels of retinol-binding protein, were far less in the endovascular group than in the open group.
Gene_expression (levels) of retinol-binding protein
5) Confidence 0.19 Published 2001 Journal Ann Vasc Surg Section Abstract Doc Link 11221945 Disease Relevance 0.59 Pain Relevance 0.22
MAIN OUTCOME MEASURE: A nutritional evaluation including body mass index and serum levels of retinol-binding protein, prealbumin and transferrin was carried out.
Gene_expression (levels) of retinol-binding protein in body
6) Confidence 0.18 Published 2010 Journal JOP Section Body Doc Link 20208327 Disease Relevance 0.14 Pain Relevance 0
It is the principal organ responsible for producing acute-phase proteins and modulating the systemic inflammatory response.14 Following thermal injury, the acute-phase response brings about the activation of the coagulation and complement cascades, granulocytes, and monocytes/macrophages as well as platelets,15–19 and induces the liver to synthesize and release proteins that exert effects on a variety of tissues.20 After major trauma, such as a severe burn, hepatic protein synthesis shifts from hepatic constitutive proteins, such as albumin, prealbumin, transferrin, and retinol-binding protein, to acute phase proteins,14 which serve as mediators of the inflammatory process, function as transport proteins, and participate in burn wound healing.21,22 Jeschke et al23 recently demonstrated that the acute-phase response persists for longer duration than previously thought, which suggests that any compromise in liver function as seen in patients with chronic liver disease has both short-term and long-term detrimental effects on the body's ability to respond to burn injury.


Gene_expression (synthesize) of retinol-binding protein in liver associated with liver disease, inflammatory response, inflammation, burns, wound healing and injury
7) Confidence 0.05 Published 2007 Journal J Burns Wounds Section Body Doc Link PMC1892842 Disease Relevance 1.66 Pain Relevance 0.13
In the liver, the rate of synthesis of selected proteins (i.e., albumin, transferrin, prealbumin, retinol-binding protein, and fibronectin) is decreased, whereas acute phase protein synthesis is accelerated [94].
Gene_expression (synthesis) of retinol-binding protein in liver
8) Confidence 0.02 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 1.21 Pain Relevance 0.18
Laboratory assessment of serum albumin, prealbumin, retinol-binding protein, and transferrin levels; cutaneous anergy testing of immune responsiveness and total lymphocyte count; and physical determinants like triceps skin fold measurement and lean body mass may be utilized and followed clinically.113 If these indicators are abnormal prior to surgical intervention, a nutritional support protocol is strongly recommended preoperatively to facilitate postoperative wound healing and minimize wound complications.114 Ultimately, the goal of preoperative support is to allow adequate protein synthesis postoperatively.115
Gene_expression (levels) of retinol-binding protein in lymphocyte associated with injury and wound healing
9) Confidence 0.01 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.33 Pain Relevance 0.03

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