INT47062

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Context Info
Confidence 0.66
First Reported 1982
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.63
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ANTXR1)
Anatomy Link Frequency
blood 2
ileum 1
eyes 1
ANTXR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 9 98.68 Very High Very High Very High
agonist 11 95.76 Very High Very High Very High
opioid receptor 12 95.44 Very High Very High Very High
antagonist 5 95.28 Very High Very High Very High
tetrodotoxin 4 89.52 High High
Neurotransmitter 1 89.32 High High
Enkephalin 2 79.96 Quite High
Delta opioid receptors 1 75.00 Quite High
cocaine 1 73.52 Quite High
methadone 1 71.20 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 23 100.00 Very High Very High Very High
Bordatella Infection 3 100.00 Very High Very High Very High
Diarrhoea 8 99.96 Very High Very High Very High
Infection 11 96.44 Very High Very High Very High
Clostridium Infection 5 96.20 Very High Very High Very High
Cough 3 96.08 Very High Very High Very High
Sneezing 1 94.64 High High
Respiratory Sounds 1 93.44 High High
Asthma 3 92.96 High High
Injury 5 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this investigation was to determine whether neural elements were essential for cholera toxin to produce a secretory effect in human isolated ileum.
Gene_expression (produce) of cholera toxin in ileum associated with vibrio infection
1) Confidence 0.66 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9331163 Disease Relevance 0.51 Pain Relevance 0.08
Cholera toxin was applied apically and short-circuit current monitored for 3 hr, at which point forskolin was given.
Gene_expression (applied) of Cholera toxin associated with vibrio infection
2) Confidence 0.66 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9331163 Disease Relevance 0.53 Pain Relevance 0.09
The red tide toxin produced by Ptychodiscus brevis becomes airborne by the thrashing action of the surf and wind and induces cough, rhinorrhea, watery eyes, and sneezing in normal humans and wheezing in asthmatic patients.
Gene_expression (produced) of toxin in eyes associated with asthma, respiratory sounds, cough and sneezing
3) Confidence 0.65 Published 1982 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 7200498 Disease Relevance 0.45 Pain Relevance 0.07
PA receptor–deficient CHO-R1.1 cells and CHO-R1.1 cells that were engineered to stably express recombinant receptor-EGFP fusion proteins, CMG2489-EGFP or ATR/TEM8 sv2-EGFP, have been described previously [22,34].
Gene_expression (express) of TEM8
4) Confidence 0.58 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0 Pain Relevance 0
Preclinical studies have demonstrated the efficacy of racecadotril in two models of hypersecretory diarrhoea: infusion of cholera toxin and castor oil-induced diarrhoea.
Gene_expression (infusion) of toxin associated with diarrhoea and vibrio infection
5) Confidence 0.19 Published 2000 Journal Int. J. Antimicrob. Agents Section Abstract Doc Link 10717505 Disease Relevance 0.52 Pain Relevance 0.16
Toxin is detected in serum or stool specimens in only approximately 46% of clinically diagnosed cases.
Gene_expression (detected) of Toxin
6) Confidence 0.04 Published 2005 Journal Eur J Emerg Med Section Abstract Doc Link 16175064 Disease Relevance 1.04 Pain Relevance 0.11
All three responses (cAMP, IP, and [Ca2+]i) were sensitive to pertussis toxin pre-treatment, suggesting the involvement of Gi/Go protein(s) in these signal transduction pathways.
Gene_expression (pre-treatment) of pertussis toxin associated with bordatella infection
7) Confidence 0.04 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8133900 Disease Relevance 0.10 Pain Relevance 0.18
Non cholera-toxin producing, non-O1, non-O139 V. cholerae have been described from blood cultures and ascitic fluid, although they are exceedingly rare isolates.
Gene_expression (producing) of toxin in blood associated with vibrio infection
8) Confidence 0.01 Published 2008 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC2373308 Disease Relevance 0.70 Pain Relevance 0
Elsewhere, non cholera-toxin producing, non-O1, non-O139 V. cholerae have been described from blood cultures and ascitic fluid, although they are exceedingly rare isolates.


Gene_expression (producing) of toxin in blood associated with vibrio infection
9) Confidence 0.01 Published 2008 Journal Ann Clin Microbiol Antimicrob Section Abstract Doc Link PMC2373308 Disease Relevance 0.44 Pain Relevance 0
Pertussis toxin prevented the response, and EGTA significantly reduced it.
Neg (prevented) Gene_expression (prevented) of toxin associated with bordatella infection
10) Confidence 0.00 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629268 Disease Relevance 0.10 Pain Relevance 0.71
Pretreatment of cells with 100 ng/ml pertussis toxin (PTX) for 24 h prevented 100 nM dopamine inhibition of PRL secretion induced by 20 mM TEA.
Gene_expression (Pretreatment) of pertussis toxin associated with dopamine and bordatella infection
11) Confidence 0.00 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7489818 Disease Relevance 0.25 Pain Relevance 0.54

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