INT47075

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1981
Last Reported 2011
Negated 0
Speculated 8
Reported most in Body
Documents 142
Total Number 150
Disease Relevance 78.55
Pain Relevance 25.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
macrophages 9
PGE2 7
plasma 3
brain 3
oocytes 3
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 314 100.00 Very High Very High Very High
Inflammation 1565 99.88 Very High Very High Very High
Inflammatory response 190 99.88 Very High Very High Very High
agonist 700 99.64 Very High Very High Very High
antagonist 529 99.32 Very High Very High Very High
COX-2 inhibitor 202 99.24 Very High Very High Very High
Arthritis 196 99.16 Very High Very High Very High
qutenza 212 98.74 Very High Very High Very High
cytokine 525 98.72 Very High Very High Very High
Hyperalgesia 37 98.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1833 100.00 Very High Very High Very High
Cancer 1464 100.00 Very High Very High Very High
Peritonitis 8 100.00 Very High Very High Very High
Hemophilus Infection 89 99.98 Very High Very High Very High
Necrosis 481 99.92 Very High Very High Very High
Pancreatic Cancer 175 99.92 Very High Very High Very High
Colon Cancer 84 99.84 Very High Very High Very High
Pulmonary Disease 752 99.80 Very High Very High Very High
Obesity 270 99.70 Very High Very High Very High
Arthritis 192 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two previous studies have indicated that activation of the PGE2 EP2 receptor can protect against excitotoxic and anoxic injury [9,10].
Positive_regulation (activation) of EP2 receptor associated with injury
1) Confidence 0.70 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.37 Pain Relevance 0.11
We have also previously reported that pharmacologic activation of EP2 receptors leads to neuroprotection via the cAMP-PKA pathway [22].
Positive_regulation (activation) of EP2
2) Confidence 0.70 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.31 Pain Relevance 0.10
Both of these previous studies led to the suggestion that activation of the PGE2 EP2 receptor can protect against ischemic injury, although no data were provided to support this hypothesis.
Positive_regulation (activation) of EP2 receptor associated with injury
3) Confidence 0.70 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.66 Pain Relevance 0.19
Based on these novel observations, we can conclude that pharmacologic stimulation of the EP2 receptor with a selective pharmacologic agent could potentially be used therapeutically in translational medicine (most likely in combination with other standard treatments) to limit brain damage following ischemic stroke.


Positive_regulation (stimulation) of EP2 receptor in brain associated with stroke
4) Confidence 0.70 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.49 Pain Relevance 0.12
While EP1 is coupled to Ca2+ mobilization, activation of EP2 and EP4 triggers stimulation of adenylyl cyclase.
Positive_regulation (activation) of EP2
5) Confidence 0.61 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.06 Pain Relevance 0
Both of these previous studies led to the suggestion that activation of the PGE2 EP2 receptor can protect against ischemic injury, although no data were provided to support this hypothesis.
Positive_regulation (activation) of PGE2 associated with injury
6) Confidence 0.61 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.66 Pain Relevance 0.19
Two previous studies have indicated that activation of the PGE2 EP2 receptor can protect against excitotoxic and anoxic injury [9,10].
Positive_regulation (activation) of PGE2 associated with injury
7) Confidence 0.61 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.36 Pain Relevance 0.11
These findings, taken together with data from the present study, suggest that elevated PGE2 within the follicle may delay resumption of meiosis in vivo, with more pronounced effects in species with longer intervals between the midcycle LH surge and ovulation.
Positive_regulation (elevated) of PGE2 in follicle
8) Confidence 0.59 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0.09 Pain Relevance 0
By contrast, the activation of EP3 decreases cAMP levels, which suggests that the selective activation of EP2 and/or EP4 might increase the clinical efficacy of PGE1 for the treatment of acute SNHL.
Positive_regulation (activation) of EP2 in PGE1 associated with sensorineural hearing loss
9) Confidence 0.56 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.65 Pain Relevance 0.22
For mechanisms of VEGF induction via EP2 or EP4 activation, recent studies have indicated involvement of cAMP- and PKA-dependent mechanisms via SP-1 transcription factor binding sites on the VEGF promoter [12,24,25].
Positive_regulation (activation) of EP2
10) Confidence 0.56 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.17 Pain Relevance 0.06
ELISA and real-time qRT-PCR analyses demonstrated an increase of VEGF protein and mRNA levels in the inner ear after local EP2 or EP4 agonist application, indicating that the stimulation of EP2 and/or EP4 activates VEGF production in the inner ear.
Positive_regulation (stimulation) of EP2 in inner ear associated with agonist
11) Confidence 0.56 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.22 Pain Relevance 0.19
The activation of EP1 elevates the levels of intracellular inositol phosphate and Ca2+ (Watabe et al. 1993), whereas the activation of EP2 or EP4 stimulates adenylate cyclase, resulting in increased levels of intracellular cAMP (Jumblatt and Paterson, 1991).
Positive_regulation (activation) of EP2
12) Confidence 0.52 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.11 Pain Relevance 0.27
Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity.
Positive_regulation (Stimulation) of EP2
13) Confidence 0.49 Published 2006 Journal J. Neurotrauma Section Title Doc Link 17184197 Disease Relevance 0.19 Pain Relevance 0.09
PGE(2)/EP1/EP3-induced airway constriction occurs indirectly through activation of neural pathways, whereas PGE(2)-induced bronchodilation results from direct activation of EP2 receptors on airway smooth muscle.
Positive_regulation (activation) of EP2 in smooth muscle
14) Confidence 0.49 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618422 Disease Relevance 0 Pain Relevance 0
These results are consistent with a mechanism wherein EP2 activation of PKA, rather than EP4 activation of PI3K, mediates the protective effect of PGE2 on mitochondria of Mtb-infected M?.


Positive_regulation (activation) of EP2 associated with mycobacterial infection
15) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.88 Pain Relevance 0
Stimulation of EP2 and EP4 receptors triggers activation of adenylate cyclase (48).
Positive_regulation (Stimulation) of EP2
16) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0 Pain Relevance 0
Measurements of relative CBF showed that tMCAO caused a reduction in cortical perfusion throughout the ischemic period that was similar in the EP2-/- and drug-treated mice to that in their corresponding controls, suggesting that neither genetic deletion nor pharmacologic activation of the EP2 receptor affected the severity of the ischemic insult.
Positive_regulation (activation) of EP2 receptor
17) Confidence 0.47 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.28 Pain Relevance 0.14
Together, our results reveal that pharmacologic stimulation of the EP2 receptor has an important beneficial role in cerebral ischemia and might be considered as an adjunct therapy for ischemic stroke.



Positive_regulation (stimulation) of EP2 receptor associated with stroke, cv general 4 under development and ischemia
18) Confidence 0.47 Published 2010 Journal Exp Transl Stroke Med Section Abstract Doc Link PMC2912268 Disease Relevance 0.38 Pain Relevance 0.11
Therefore, our goal was to determine whether the anatomical protective effects of EP2 activation are sustained over time (and are not only transient or delayed) and whether such changes correlate with neurologic improvements.
Spec (whether) Positive_regulation (activation) of EP2
19) Confidence 0.47 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.44 Pain Relevance 0.19
Therefore, we chose to directly activate the EP2 receptor with a selective agonist to complement the findings in knockout mice.
Positive_regulation (activate) of EP2 receptor associated with targeted disruption and agonist
20) Confidence 0.47 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.55 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox