INT47079

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Context Info
Confidence 0.75
First Reported 1980
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 7.28
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs) extracellular region (Apcs) protein complex assembly (Apcs)
protein complex (Apcs)
Anatomy Link Frequency
blood 1
plasma 1
Apcs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 49 99.68 Very High Very High Very High
anesthesia 2 98.28 Very High Very High Very High
Inflammation 27 92.52 High High
Inflammatory response 10 91.52 High High
cytokine 8 91.20 High High
antagonist 2 87.08 High High
dexamethasone 41 65.64 Quite High
Bile 25 26.96 Quite Low
medulla 13 5.00 Very Low Very Low Very Low
epidural 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 171 100.00 Very High Very High Very High
Obstructive Jaundice 122 100.00 Very High Very High Very High
Hypertension 12 99.64 Very High Very High Very High
INFLAMMATION 89 99.48 Very High Very High Very High
Heart Rate Under Development 1 98.88 Very High Very High Very High
Injury 21 98.24 Very High Very High Very High
Multiple Organ Failure 15 83.92 Quite High
Necrosis 21 75.08 Quite High
Hypotension 2 75.00 Quite High
Adhesions 1 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ouabain was administered i.p. 30 min after induction of anesthesia with alpha-chloralose (60 mg/kg i.p.). alpha-Chloralose alone produced a significant SAP decrease in both SH and NT rats and bradycardia in SH but no significant HR change in NT rats.
Localization (decrease) of SAP associated with heart rate under development, anesthesia and hypertension
1) Confidence 0.75 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205616 Disease Relevance 1.03 Pain Relevance 0.10
and PLA2 in model control group were significantly higher than those in sham-operated group [10, 12–14], suggesting that inflammatory mediators were massively released in SAP and OJ.
Localization (released) of SAP associated with inflammatory mediators, pancreatitis and obstructive jaundice
2) Confidence 0.59 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.52 Pain Relevance 0.30
The results of this study showed that the contents of plasma endotoxin in SAP and OJ rats in model control group were significantly higher than those in sham-operated group, indicating that SAP and OJ can increase the contents of plasma endotoxin in rats.
Localization (increase) of SAP in plasma associated with pancreatitis and obstructive jaundice
3) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.41 Pain Relevance 0
closely related with SAP severity, and the PLA2 inhibitor can improve the
Localization (related) of SAP associated with pancreatitis
4) Confidence 0.37 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.50 Pain Relevance 0.48
In SAP and OJ, PLA2 is activated and massively released into the blood.
Localization (released) of SAP in blood associated with pancreatitis and obstructive jaundice
5) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.82 Pain Relevance 0.23

General Comments

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