INT47127

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 17.09
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BGN) proteinaceous extracellular matrix (BGN) biological_process (BGN)
Anatomy Link Frequency
urine 3
plasma 1
bowel 1
vascular endothelium 1
BGN (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 192 100.00 Very High Very High Very High
cINOD 165 99.54 Very High Very High Very High
aspirin 262 99.20 Very High Very High Very High
abdominal pain 6 99.02 Very High Very High Very High
adenocard 1 98.80 Very High Very High Very High
Pain 104 95.52 Very High Very High Very High
spastic colon 40 94.48 High High
bradykinin 14 91.04 High High
depression 8 82.60 Quite High
vaginimus 8 78.36 Quite High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 1472 100.00 Very High Very High Very High
Syndrome 312 100.00 Very High Very High Very High
Sleep Disorders 192 100.00 Very High Very High Very High
Abdominal Pain 6 99.02 Very High Very High Very High
Pain 111 95.52 Very High Very High Very High
Functional Bowel Disorder 40 94.48 High High
Atherosclerosis 34 84.48 Quite High
Depression 8 82.60 Quite High
Vasculitis 1 81.36 Quite High
Fatigue 88 80.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that co-incident treatment with ASA might protect against unfavorable NSAID-induced shifts in the production of TxA2 and PGI2.
Gene_expression (production) of PGI associated with aspirin and cinod
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0 Pain Relevance 0.61
The present study of children with and without RAP has revealed no significant difference in serum PgI levels in these groups.
Gene_expression (levels) of PgI associated with abdominal pain
2) Confidence 0.55 Published 1981 Journal Clin Pediatr (Phila) Section Abstract Doc Link 7226682 Disease Relevance 0.32 Pain Relevance 0.50
We undertook analyses of urine and plasma samples from ADAPT participants to determine whether naproxen or celecoxib treatment in individuals 70 years or older produced changes in urine Tx-M and PGI-M levels that were similar to findings reported previously in younger individuals.
Spec (whether) Gene_expression (produced) of PGI-M in urine
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0 Pain Relevance 0.64
0.001), but not ASA use (P>0.05) significantly affected urine Tx-M/PGI-M ratio.
Gene_expression (ratio) of PGI-M in urine associated with aspirin
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0.16 Pain Relevance 0.36
Urine Tx-M and, to a lesser degree, urine PGI-M concentrations also were reduced significantly with ASA use in the compliant group (P<0.0001 and P<0.05).
Gene_expression (reduced) of PGI-M in urine associated with aspirin
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0 Pain Relevance 0.38
We undertook analyses of urine and plasma samples from ADAPT participants to determine whether naproxen or celecoxib treatment in individuals 70 years or older produced changes in urine Tx-M and PGI-M levels that were similar to findings reported previously in younger individuals.
Spec (whether) Gene_expression (produced) of PGI-M in plasma
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0 Pain Relevance 0.64
The pooled CFS and PGI groups, and CFS individuals also had equivalent scores for each domain.
Gene_expression (groups) of PGI associated with chronic fatigue syndrome
7) Confidence 0.08 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 2.13 Pain Relevance 0.25
There was a high degree of overlap of the syndromes of CFS, PGI, and FM within the pooled CFS and pooled PGI groups, and the CFS individuals (figure 1).
Gene_expression (groups) of PGI associated with chronic fatigue syndrome, syndrome and fibrositis
8) Confidence 0.08 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 2.38 Pain Relevance 0.30
In this study, groups of subjects were recruited based on the presence of FM, PGI, and no other syndrome (healthy control, HC).
Gene_expression (presence) of PGI associated with syndrome and fibrositis
9) Confidence 0.08 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.68 Pain Relevance 0.49
When subjects from the FM and PGI groups were assessed more intensively, they were found to simultaneously satisfy the case designation criteria for several of the CFS, PGI, FM, irritable bowel syndrome, and other syndromes.
Gene_expression (groups) of PGI in bowel associated with chronic fatigue syndrome, syndrome, spastic colon and fibrositis
10) Confidence 0.08 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.66 Pain Relevance 0.49
Scores for CFS and PGI groups were significantly higher than HC.
Gene_expression (groups) of PGI associated with chronic fatigue syndrome
11) Confidence 0.08 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.44 Pain Relevance 0.44
There was a high degree of overlap of the syndromes of CFS, PGI, and FM within the pooled CFS and pooled PGI groups, and the CFS individuals (figure 1).
Gene_expression (syndromes) of PGI associated with chronic fatigue syndrome, syndrome and fibrositis
12) Confidence 0.08 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 2.32 Pain Relevance 0.29
There was a high degree of overlap of the syndromes of CFS, PGI, and FM within the pooled CFS and pooled PGI groups, and the CFS individuals (figure 1).
Gene_expression (groups) of PGI associated with chronic fatigue syndrome, syndrome and fibrositis
13) Confidence 0.08 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 2.36 Pain Relevance 0.30
PGI was present in 13/29 and FM in 11/29.
Gene_expression (present) of PGI associated with fibrositis
14) Confidence 0.07 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 2.26 Pain Relevance 0.30
PGI-2 is considered to be the main prostanoid synthesized by vascular endothelium, while thromboxane A2 (TX-A2) is the main prostanoid produced by platelets.
Gene_expression (synthesized) of PGI-2 in vascular endothelium
15) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.39 Pain Relevance 0.26

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