INT4715

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 6.57
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xdh) oxidoreductase activity (Xdh) extracellular region (Xdh)
peroxisome (Xdh) cytoplasm (Xdh)
Anatomy Link Frequency
small intestine 3
blood 2
plasma 1
leukocytes 1
liver 1
Xdh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 105 99.98 Very High Very High Very High
halothane 2 99.56 Very High Very High Very High
colic 8 99.54 Very High Very High Very High
anesthesia 17 99.16 Very High Very High Very High
diabetic neuropathy 2 97.60 Very High Very High Very High
cINOD 13 91.72 High High
Inflammation 10 79.76 Quite High
cytokine 3 79.44 Quite High
Brush evoked pain 1 34.88 Quite Low
Thermal hyperalgesia 1 33.12 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 97 99.98 Very High Very High Very High
Abdominal Cramps 5 99.54 Very High Very High Very High
Stress 29 99.42 Very High Very High Very High
Death 1 99.38 Very High Very High Very High
Poisoning 58 99.18 Very High Very High Very High
Diabetic Neuropathy 2 97.60 Very High Very High Very High
Diabetes Mellitus 8 96.56 Very High Very High Very High
Hepatotoxicity 6 95.36 Very High Very High Very High
Rupture 1 93.48 High High
Injury 121 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim was to assess the involvement of elevated xanthine oxidase activity.
Positive_regulation (elevated) of xanthine oxidase
1) Confidence 0.69 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17291486 Disease Relevance 0.38 Pain Relevance 0.05
Among the biochemical parameters, plasma xanthine oxidase (XO) activity was found to be more elevated in the cisplatin group than the saline group (p<0.05).
Positive_regulation (elevated) of xanthine oxidase in plasma
2) Confidence 0.49 Published 2004 Journal J Chemother Section Abstract Doc Link 15332714 Disease Relevance 0 Pain Relevance 0.08
Xanthine oxidase activity was found to be increased in omega-3 EFA treated rats when compared to the control group (p < 0.0001).
Positive_regulation (increased) of Xanthine oxidase
3) Confidence 0.43 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15276695 Disease Relevance 0.07 Pain Relevance 0.08
Evidence of oxidative stress was found in the mucosa of the small intestine of drug-treated rats, as indicated by significantly increased activity of xanthine oxidase (P < 0.001) and myeloperoxidase (P < 0.001), with corresponding decreases in the levels of several free radical scavenging enzymes and alpha-tocopherol (P < 0.001 in all cases).
Positive_regulation (increased) of xanthine oxidase in small intestine associated with stress
4) Confidence 0.42 Published 2004 Journal Clin. Sci. Section Abstract Doc Link 15128285 Disease Relevance 0.47 Pain Relevance 0.11
Xanthine-oxidase activity increased significantly after administration of the drug.
Positive_regulation (increased) of Xanthine-oxidase
5) Confidence 0.35 Published 2000 Journal Inflamm. Res. Section Body Doc Link 10959558 Disease Relevance 0 Pain Relevance 0
Halothan anesthesia was found to be hapatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine oxidase (SXO) level.
Positive_regulation (elevation) of serum xanthine oxidase associated with anesthesia
6) Confidence 0.34 Published 1976 Journal Experientia Section Abstract Doc Link 1278316 Disease Relevance 0.10 Pain Relevance 0.21
Prior to death, blood samples were drawn for measurement of superoxide dismutase, xanthine oxidase (XO), malondialdehyde and nitric oxide.
Positive_regulation (measurement) of xanthine oxidase in blood associated with death
7) Confidence 0.33 Published 2005 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 15742177 Disease Relevance 0.18 Pain Relevance 0.10
Evidence of oxidative stress was found in the mucosa of the small intestine of drug-treated rats, as indicated by significantly increased activity of xanthine oxidase (P < 0.001) and myeloperoxidase (P < 0.001), with corresponding decreases in the levels of several free radical scavenging enzymes and alpha-tocopherol (P < 0.001 in all cases).
Positive_regulation (activity) of xanthine oxidase in small intestine associated with stress
8) Confidence 0.28 Published 2004 Journal Clin. Sci. Section Abstract Doc Link 15128285 Disease Relevance 0.47 Pain Relevance 0.11
Drug-induced oxidative stress was also evident as seen by increases in the levels of malondialdehyde and protein carbonyl and in activities of pro-oxidant enzymes such as myeloperoxidase and xanthine oxidase in indomethacin-treated rats.
Positive_regulation (increases) of xanthine oxidase associated with stress
9) Confidence 0.26 Published 2007 Journal J Appl Toxicol Section Abstract Doc Link 17351913 Disease Relevance 0.37 Pain Relevance 0.26
Evidence of oxidative stress was found in the mucosa of the small intestine of rats dosed with indomethacin, as indicated by increased activity of xanthine oxidase with corresponding decrease in the levels of several free radical scavenging enzymes.
Positive_regulation (increased) of xanthine oxidase in small intestine associated with stress
10) Confidence 0.26 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12566098 Disease Relevance 0.26 Pain Relevance 0.24
During ischemia xanthine dehydrogenase is converted to xanthine oxidase which catalyses the reaction of xanthine to hypoxanthine that is subsequently accumulated in intestinal tissue due to ischemia.
Positive_regulation (converted) of xanthine oxidase associated with ischemia
11) Confidence 0.25 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496980 Disease Relevance 0.43 Pain Relevance 0.14
Xanthine oxidase (XOD) activity in the gastric mucosa also increased immediately after administration of the drug.
Positive_regulation (increased) of Xanthine oxidase
12) Confidence 0.24 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8741581 Disease Relevance 0.41 Pain Relevance 0.09
Elevation of serum xanthine oxidase following halothane anesthesia in the rat.
Positive_regulation (Elevation) of serum xanthine oxidase associated with anesthesia and halothane
13) Confidence 0.23 Published 1976 Journal Experientia Section Title Doc Link 1278316 Disease Relevance 0.09 Pain Relevance 0.25
During ischemia xanthine dehydrogenase is converted to xanthine oxidase which catalyses the reaction of xanthine to hypoxanthine that is subsequently accumulated in intestinal tissue due to ischemia.
Positive_regulation (converted) of xanthine dehydrogenase associated with ischemia
14) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496980 Disease Relevance 0.43 Pain Relevance 0.14
High-cholesterol diet increases xanthine oxidase and decreases nitric oxide synthase activities in erythrocytes from rats.
Positive_regulation (increases) of xanthine oxidase in erythrocytes
15) Confidence 0.16 Published 2008 Journal Nutr Res Section Title Doc Link 19083410 Disease Relevance 0.12 Pain Relevance 0.07
In the liver of CCl4-intoxicated rats, increases in lipid peroxide (LPO) concentration and myeloperoxidase activity and decreases in superoxixde dismutase activity and reduced glutathione (GSH) concentration occurred 6 h after intoxication and these changes were enhanced with an increase in xanthine oxidase activity and a decrease in catalase activity at 24 h.
Positive_regulation (increase) of xanthine oxidase in liver associated with poisoning
16) Confidence 0.13 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266062 Disease Relevance 0.50 Pain Relevance 0
Octacosanol (10, 50 or 100 mg/kg) administered orally to CCl4-intoxicated rats at 6 h after intoxication attenuated the increased activities of serum transaminases and the increased hepatic myeloperoxidase and xanthine oxidase activities and LPO concentration and the decreased hepatic superoxide dismutase and catalase activities and GSH concentration found at 24 h after intoxication dose-dependently.
Positive_regulation (increased) of xanthine oxidase associated with poisoning
17) Confidence 0.06 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2266062 Disease Relevance 0.50 Pain Relevance 0
To assess right colic artery blood flow and relevance of xanthine dehydrogenase/xanthine oxidase after experimentally induced strangulation obstruction and reperfusion of the colon, 5 ponies were subjected to 2.5 hours of complete ischemia of the left dorsal and ventral colons, allowed to recover from surgery, and monitored during a 48-hour reperfusion period.
Positive_regulation (relevance) of xanthine dehydrogenase in blood associated with colic and ischemia
18) Confidence 0.02 Published 1994 Journal Am. J. Vet. Res. Section Abstract Doc Link 7978659 Disease Relevance 0.32 Pain Relevance 0.16
Other mechanisms contributing reactive oxygen free radical formation and membrane lipid peroxidation include metabolism of arachidonic acid via the cyclooxygenase and lipoxygenase pathways, reactions catalyzed by increased free intracellular Fe++, and increased xanthine oxidase activity as a result of increased degradation of ATP (28).
Positive_regulation (increased) of xanthine oxidase
19) Confidence 0.02 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816844 Disease Relevance 0.57 Pain Relevance 0.08
Reperfusion of the ischemic tissue promotes the generation of ROS, which arises from activation of the xanthine oxidase system in parenchymal cells or from leukocytes penetrating into interstitial tissue.
Positive_regulation (activation) of xanthine oxidase in leukocytes
20) Confidence 0.02 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2991579 Disease Relevance 0.91 Pain Relevance 0.12

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