INT47162

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
plasma 2
Maoa (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 15 100.00 Very High Very High Very High
Clonidine 4 99.96 Very High Very High Very High
agonist 7 99.74 Very High Very High Very High
Dopamine 4 98.52 Very High Very High Very High
noradrenaline 2 98.00 Very High Very High Very High
Serotonin 2 96.68 Very High Very High Very High
antagonist 1 96.22 Very High Very High Very High
dopamine receptor 2 84.20 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alpha 2-adrenoceptor agonist, clonidine, induced a moderate inhibition (12-18%) of islet monoamine oxidase activity, accompanied by reduced plasma insulin and elevated plasma glucose levels.
Positive_regulation (induced) of Negative_regulation (inhibition) of islet monoamine oxidase in plasma associated with agonist, monoamine and clonidine
1) Confidence 0.45 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.83
The alpha-adrenoceptor agonist clonidine, 0.1 mg/kg i.p., reduced the formation of normetanephrine and the alpha-adrenoceptor antagonists yohimbine, 10 mg per kg i.p., phenoxybenzamine, 20 mg/kg i.p., and mianserine, 50 mg/kg i.p., stimulated normetanephrine accumulation 1.5- to 4-fold. 3-Methoxytyramine and normetanephrine accumulating after inhibition of monoamine oxidase appear to be reliable indicators of dopamine and noradrenaline release and metabolism.
Positive_regulation (accumulating) of Negative_regulation (inhibition) of monoamine oxidase associated with dopamine, antagonist, noradrenaline, agonist, monoamine and clonidine
2) Confidence 0.31 Published 1981 Journal J. Neural Transm. Section Abstract Doc Link 7241115 Disease Relevance 0 Pain Relevance 0.59

General Comments

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