INT47186

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Context Info
Confidence 0.50
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.07
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCTR) signal transducer activity (SCTR)
Anatomy Link Frequency
fat 1
pancreas 1
nasal 1
SCTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 4 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Chronic pancreatitis 6 99.54 Very High Very High Very High
adenocard 8 94.88 High High
halothane 64 93.56 High High
ketamine 1 91.88 High High
Pain 2 91.08 High High
anesthesia 1 89.64 High High
Somatostatin 1 82.44 Quite High
Cholecystokinin 4 79.40 Quite High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 144 99.72 Very High Very High Very High
Pancreatitis 12 99.54 Very High Very High Very High
Exocrine Pancreatic Insufficiency 1 98.84 Very High Very High Very High
Acalculous Cholecystitis 1 95.36 Very High Very High Very High
Contracture 104 94.40 High High
Duodenal Ulcer 1 92.08 High High
Muscle Disease 8 91.80 High High
Duodenal Obstruction 1 91.12 High High
Pain 2 91.08 High High
Pancreatic Fistula 1 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diagnostic value of the fecal chymotrypsin test in pancreatic insufficiency, particularly chronic pancreatitis: correlation with the pancreozymin-secretin test, fecal fat excretion and final clinical diagnosis.
Localization (excretion) of pancreozymin-secretin in fat associated with bile, exocrine pancreatic insufficiency and chronic pancreatitis
1) Confidence 0.50 Published 1981 Journal Digestion Section Title Doc Link 7250549 Disease Relevance 0.46 Pain Relevance 0.28
Then, separation of the SR and SO was carefully performed, and the SO tendon was exposed near the nasal border of the SR by a muscle hook under direct visualization.
Localization (separation) of SR in nasal
2) Confidence 0.48 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2739957 Disease Relevance 0.06 Pain Relevance 0.16
Recently described secretin receptor antagonists may also have therapeutic value as a means of selectively inhibiting pancreatic secretion of water and electrolytes.




Localization (secretion) of secretin receptor associated with antagonist
3) Confidence 0.06 Published 1992 Journal The Yale Journal of Biology and Medicine Section Abstract Doc Link PMC2589733 Disease Relevance 0.79 Pain Relevance 0.68
While SR Ca2+ release was extensively studied in MH [15], the impact of an altered SR Ca2+ reuptake on the pathogenesis of MH by intrinsic or extrinsic factors is poorly understood.
Localization (release) of SR associated with malignant hyperthermia
4) Confidence 0.03 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1175794 Disease Relevance 0.91 Pain Relevance 0.03
Undoubtly, an altered SR Ca2+ release plays a crucial role in the development of MH.
Localization (release) of SR associated with malignant hyperthermia
5) Confidence 0.03 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1175794 Disease Relevance 0.87 Pain Relevance 0.06
In MH uncontrolled SR Ca2+ release, caused by MH associated mutations mainly in the ryanodine receptor gene, is widely accepted as the underlying pathophysiological mechanism of hypermetabolism [8].
Localization (release) of SR associated with malignant hyperthermia
6) Confidence 0.03 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1175794 Disease Relevance 0.88 Pain Relevance 0.09
Due to MH-associated mutations in the ryanodine receptor, triggering agents such as halogenated anaesthetics cause an excessive Ca2+ release from the SR resulting in intracellular hypermetabolism, increased mitochondrial energy-turnover and metabolic failure with a deficiency of adenosine-triphosphate [2].
Localization (release) of SR associated with adenocard and malignant hyperthermia
7) Confidence 0.03 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1175794 Disease Relevance 0.50 Pain Relevance 0.08
Difficulties of examining the external secretion of the pancreas by direct secretin-pancreozymin test prompted us to try 4 probe-free methods for functional assessment of the pancreas in 33 patients with chronic acalculous cholecystitis, 50 patients with reactive pancreatitis concomitant with duodenal ulcer, chronic duodenal obstruction, etc., and in 22 patients with primary chronic pancreatitis during a relapse.
Localization (secretion) of secretin-pancreozymin in pancreas associated with duodenal obstruction, bile, duodenal ulcer, pancreatitis, chronic pancreatitis, recurrence and acalculous cholecystitis
8) Confidence 0.01 Published 1997 Journal Klin. Lab. Diagn. Section Abstract Doc Link 9377019 Disease Relevance 0.60 Pain Relevance 0.17

General Comments

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