INT47201

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Context Info
Confidence 0.38
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.15
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 1
spinal 1
brain stem 1
peritoneal macrophages 1
RT1-EC2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 16 99.44 Very High Very High Very High
Neuritis 23 98.56 Very High Very High Very High
local anesthetic 2 97.44 Very High Very High Very High
lidocaine 4 97.24 Very High Very High Very High
Eae 10 95.96 Very High Very High Very High
cytokine 8 90.44 High High
Endep 6 87.96 High High
Dorsal horn 2 87.68 High High
Nortriptyline 4 87.36 High High
tolerance 4 85.04 High High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 23 98.56 Very High Very High Very High
Demyelinating Disease 4 98.48 Very High Very High Very High
Autoimmune Disease 5 97.92 Very High Very High Very High
Injury 12 95.96 Very High Very High Very High
Sprains And Strains 47 87.20 High High
Atherosclerosis 1 76.84 Quite High
Necrosis 3 64.60 Quite High
Cancer 2 64.24 Quite High
INFLAMMATION 20 62.16 Quite High
Neuropathic Pain 1 60.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the modulation of IFN-gamma induced MHC class I and II expression on normal Lewis rats and rats with EAN peritoneal macrophages cultured in the absence or presence of 10(-4)-10(-8) M of the 5-HT reuptake inhibiting antidepressants zimeldine, and its metabolites norzimeldine and cpp200 oxalate as well as the antidepressants clomipramine and imipramine, in addition amitriptyline, nortriptyline and maprotiline in EAN rats.
Gene_expression (expression) of MHC class I and II in peritoneal macrophages associated with nortriptyline, antidepressant, endep and neuritis
1) Confidence 0.38 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.33 Pain Relevance 0.62
The modulatory effect of antidepressant drugs on IFN-gamma induced MHC class I and II expression may contribute to their influence on demyelinating autoimmune diseases, and may have implications for their clinical use.
Gene_expression (expression) of MHC class I and II associated with antidepressant, autoimmune disease and demyelinating disease
2) Confidence 0.38 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.59 Pain Relevance 0.63
Assays of acylCoA : cholesterol acyltransferase (ACAT, EC 2.3.1.26) in isolated arterial microsomes revealed that, in addition to local anesthetics (e.g., lidocaine), other membrane-active agents such as chlorpromazine and methoxyflurane inhibit ACAT; this suggests ACAT may be regulated by alterations in the biophysical properties of its membrane milieu.
Gene_expression (Assays) of EC 2.3.1.26 associated with lidocaine and local anesthetic
3) Confidence 0.33 Published 1981 Journal Atherosclerosis Section Abstract Doc Link 7259830 Disease Relevance 0.08 Pain Relevance 0.51
The modulatory effect of antidepressant drugs on IFN-gamma induced MHC class I and II expression may contribute to their influence on demyelinating autoimmune diseases, and may have implications for their clinical use.
Gene_expression (expression) of MHC class I and II associated with antidepressant, autoimmune disease and demyelinating disease
4) Confidence 0.32 Published 1997 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 10975734 Disease Relevance 0.89 Pain Relevance 0.80
MHC I was expressed in DRGs and in spinal sciatic territories to a similar extent after both lesions.
Gene_expression (expressed) of MHC I in spinal
5) Confidence 0.10 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17187959 Disease Relevance 0.86 Pain Relevance 0.78
In the trigeminal ganglia of DA rats up-regulation of MHC I was seen from 12 hpi, and MHC II from 3 dpi, whereas in the brain stem level of MHC I expression was increased from 2 dpi and level of MHC II expression from 3 dpi.
Gene_expression (expression) of MHC I in brain stem
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.23 Pain Relevance 0
It was recently found that LSEC constitutively express all molecules necessary for antigen presentation: CD54, CD80, CD86, MHC class I and II, and CD40, and can function as antigen-presenting cells for CD4+ and CD8+ T cells [67,68].
Gene_expression (express) of MHC class I and II in CD86
7) Confidence 0.05 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.17 Pain Relevance 0.14

General Comments

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