INT4721

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2006
Negated 2
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 2.08
Pain Relevance 9.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
respiratory 3
spinal cord 1
lateral reticular nucleus 1
epithelium 1
Nka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 54 100.00 Very High Very High Very High
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
Analgesic 2 99.98 Very High Very High Very High
qutenza 43 99.80 Very High Very High Very High
tetrodotoxin 6 99.32 Very High Very High Very High
antagonist 18 99.06 Very High Very High Very High
bradykinin 11 99.04 Very High Very High Very High
Nicotine 4 98.56 Very High Very High Very High
Raphe magnus 5 97.24 Very High Very High Very High
Spinal cord 10 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 2 97.52 Very High Very High Very High
Hypersensitivity 2 97.26 Very High Very High Very High
Cough 3 97.00 Very High Very High Very High
Pain 4 95.08 Very High Very High Very High
Asthma 2 93.04 High High
Disease 2 90.20 High High
Dyspnea 2 85.96 High High
Shock 2 83.76 Quite High
Right Ventricular Hypertrophy 5 81.80 Quite High
Hypertension 5 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NKA dropped as corticosterone levels peaked postoperatively, and administration of relevant doses of corticosterone suppressed NKA.
Negative_regulation (suppressed) of NKA
1) Confidence 0.59 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12742657 Disease Relevance 0 Pain Relevance 0.18
Inhibition of glucocorticoid synthesis prevented plasma from suppressing NKA but merely attenuated NKA suppression in operated rats.
Negative_regulation (suppressing) of NKA in plasma
2) Confidence 0.51 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12742657 Disease Relevance 0 Pain Relevance 0.18
Using the microinjection technique, the analgesic effect of neurokinin A (NKA) microinjected into the lateral reticular nucleus (LRN) and nucleus raphe magnus (NRM) was investigated in lightly pentobarbital-anesthetized rats using tail flick latency (TFL) as an index.
Spec (investigated) Negative_regulation (effect) of NKA in lateral reticular nucleus associated with raphe magnus, analgesic and tail-flick
3) Confidence 0.43 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9387783 Disease Relevance 0 Pain Relevance 0.48
Capsaicin significantly decreased lung levels of SP but not NKA.
Negative_regulation (decreased) of NKA in lung associated with qutenza and substance p
4) Confidence 0.39 Published 2000 Journal Chin J Physiol Section Abstract Doc Link 11292182 Disease Relevance 0.60 Pain Relevance 0.87
We studied plasma factors mediating suppression of NK activity (NKA) following surgery.
Negative_regulation (suppression) of NKA in plasma
5) Confidence 0.38 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12742657 Disease Relevance 0 Pain Relevance 0.16
Thus, postoperative concentrations of corticosterone can directly suppress NKA but additional factors probably act in vivo.
Negative_regulation (suppress) of NKA
6) Confidence 0.38 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12742657 Disease Relevance 0 Pain Relevance 0.17
Inhibition of glucocorticoid synthesis prevented plasma from suppressing NKA but merely attenuated NKA suppression in operated rats.
Negative_regulation (suppression) of NKA in plasma
7) Confidence 0.38 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12742657 Disease Relevance 0 Pain Relevance 0.18
One hour after rizatriptan administration, a decrease in CGRP and NKA levels was evident in the external jugular venous blood of rizatriptan responders, and this corresponded to a significant pain relief and alleviation of accompanying symptoms.
Negative_regulation (decrease) of NKA in blood associated with pain and calcitonin gene-related peptide
8) Confidence 0.30 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16472331 Disease Relevance 0.39 Pain Relevance 0.62
[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-SP also inhibited the responses to NKA and its analogs but had no effect on the response to SP.
Negative_regulation (inhibited) of NKA associated with substance p
9) Confidence 0.25 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2430095 Disease Relevance 0 Pain Relevance 0.87
Thus whereas behavioral hypersensitivity after injury is preserved in ppt-A -/- mice, our results suggest that the magnitude and duration of these behavioral responses would be reduced in the absence of SP and/or NKA.
Negative_regulation (reduced) of NKA associated with injury, hypersensitivity and substance p
10) Confidence 0.14 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14711972 Disease Relevance 0.19 Pain Relevance 0.36
The effect of epithelium removal was abolished for NKA, but not for NKB.
Neg (not) Negative_regulation (abolished) of NKA in epithelium
11) Confidence 0.07 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2464059 Disease Relevance 0 Pain Relevance 0.55
It also inhibited CGRP and NKA release and bronchoconstriction caused by pH 5 buffer in lung, as well as cough and nasal irritation provoked by citric acid in vivo.
Negative_regulation (inhibited) of NKA in nasal associated with cough and calcitonin gene-related peptide
12) Confidence 0.07 Published 1993 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 7694442 Disease Relevance 0.10 Pain Relevance 1.59
The cyclo-oxygenase inhibitor, piroxicam (10 microM) and the neuronal conduction blocker, tetrodotoxin (TTX) (0.1 microM) both significantly decreased the SP (0.1 microM) (66% and 36%, respectively) and NKA (1 microM) (64% and 31%, respectively) induced increase in short-circuit current (SCC).
Negative_regulation (decreased) of NKA in neuronal associated with tetrodotoxin and substance p
13) Confidence 0.06 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9809803 Disease Relevance 0 Pain Relevance 0.71
The increased release of NKA was unaffected by hexamethonium.
Neg (unaffected) Negative_regulation (unaffected) of NKA
14) Confidence 0.04 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 1972607 Disease Relevance 0.14 Pain Relevance 0.32
Its ability to inhibit SP, NKA and capsaicin-mediated respiratory effects was examined in guinea pigs in vivo.
Negative_regulation (inhibit) of NKA in respiratory associated with qutenza
15) Confidence 0.04 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627566 Disease Relevance 0.22 Pain Relevance 0.37
These data suggest that MDL 105,212A is a potent NK-1 and NK-2 receptor antagonist based on in vitro activity and its ability to inhibit SP and NKA mediated respiratory effects in vivo after exogenous administration or endogenous release and hence may be a useful therapeutic agent in neuroinflammatory disorders such as asthma in which a role for both tachykinins in the pathogenesis of the disease has been postulated.
Negative_regulation (inhibit) of NKA in respiratory associated with asthma, antagonist and disease
16) Confidence 0.04 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627566 Disease Relevance 0.43 Pain Relevance 0.35
These results suggest that NEP inhibitors may have adverse respiratory effects resulting from inhibition of the degradation of neurokinins, but mainly of NKA, when a large amount of BK is generated.
Negative_regulation (inhibition) of NKA in respiratory associated with bradykinin
17) Confidence 0.04 Published 2001 Journal Life Sci. Section Abstract Doc Link 11764001 Disease Relevance 0 Pain Relevance 0.54
Capsaicin administration (subcutaneously) during the early postnatal period increased latency in a hot-plate test, decreased SP and NKA levels, increased levels of PPT mRNAs, and did not affect SPR mRNA levels in the spinal cord.
Negative_regulation (decreased) of NKA in spinal cord associated with qutenza, spinal cord and substance p
18) Confidence 0.03 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1279124 Disease Relevance 0 Pain Relevance 1.08

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