INT4723

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Context Info
Confidence 0.71
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 8.33
Pain Relevance 11.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
striatum 5
nucleus accumbens 3
posterior 2
nerve 1
lateral 1
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 130 100.00 Very High Very High Very High
Neuropeptide 22 100.00 Very High Very High Very High
calcitonin gene related peptide 11 100.00 Very High Very High Very High
Nucleus accumbens 23 99.96 Very High Very High Very High
Dopamine 65 99.62 Very High Very High Very High
monoamine 4 98.90 Very High Very High Very High
Spinal cord 21 98.76 Very High Very High Very High
Dynorphin 2 98.32 Very High Very High Very High
nociceptor 35 97.64 Very High Very High Very High
Enkephalin 22 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 4 99.44 Very High Very High Very High
Parkinson's Disease 51 99.36 Very High Very High Very High
Hypersensitivity 38 98.82 Very High Very High Very High
Respiratory Syncytial Virus 27 98.76 Very High Very High Very High
Infection 12 98.60 Very High Very High Very High
Dystonia 30 96.56 Very High Very High Very High
Dyskinesias 16 92.92 High High
Ganglion Cysts 85 90.76 High High
INFLAMMATION 63 87.16 High High
Cystitis 15 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results support the idea that substance P is an important mediator of thermal hypersensitivity in the setting of nerve injury and suggest that increased NK-1 receptor transcription precedes increased NK-1 receptor density, ultimately leading to behavioral hypersensitivity to peripheral thermal stimulation.
Transcription (transcription) of NK-1 in nerve associated with nervous system injury, hypersensitivity and substance p
1) Confidence 0.71 Published 2004 Journal J Pain Section Abstract Doc Link 15042514 Disease Relevance 0.83 Pain Relevance 1.06
Importantly, EM2 immunostaining persisted in mice with a deletion of the preprotachykinin-A gene that encodes SP.
Transcription (deletion) of preprotachykinin-A associated with substance p
2) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078552 Disease Relevance 0.07 Pain Relevance 1.03
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Transcription (levels) of Tac1 associated with calcitonin gene related peptide, neuropeptide and substance p
3) Confidence 0.52 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.54 Pain Relevance 1.10
Consistent with these findings, 3 h treatment with E2 caused an increase in Tac1 mRNA levels.
Transcription (levels) of Tac1
4) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.05 Pain Relevance 0.19
Tac1 mRNA levels remained low in mice after 72 h treatment with E2 (Fig. 2A).
Transcription (levels) of Tac1
5) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
The transcripts for Tac1, Tac2, Tac4, Tacr1, Tacr2 and Tacr3 were detected in uteri from ovariectomized mice.
Transcription (detected) of Tac1
6) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
The transcripts for Tac1, Tac2, Tac4, Tacr1, Tacr2 and Tacr3 were detected in uteri from ovariectomized mice.
Transcription (transcripts) of Tac1
7) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
With this approach, we found that Tac1 mRNA levels were 4.5- and 3.0-fold higher in untreated ovariectomized mice, than in estrus and diestrus virgin mice, respectively (unpublished observations).
Transcription (levels) of Tac1
8) Confidence 0.51 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
A specific probe (n° 88, Home probe Library, Exiqon, Vedbaek, Denmark), chosen with the program Probefinder assay design (Exiqon), was used to detect the Tac1 transcript (88 bp) since this gene was present in faint amounts in uteri from pregnant and non-pregnant mice [29].
Transcription (detect) of Tac1
9) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of PPT in nucleus accumbens associated with nucleus accumbens and dopamine
10) Confidence 0.43 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.63
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Transcription (expression) of PPT in nucleus accumbens associated with nucleus accumbens
11) Confidence 0.43 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.33 Pain Relevance 0.58
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of preprotachykinin in nucleus accumbens associated with nucleus accumbens and dopamine
12) Confidence 0.43 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.63
The acute effects of the monoamine releaser p-chloroamphetamine (pCA, 10 mg/kg, i.p.) on preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the anterior (A-STR) vs. posterior (P-STR) striatum were studied in rodents at postnatal days (PND) 10, 21 and 35.
Transcription (expression) of PPT in posterior associated with monoamine
13) Confidence 0.42 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9974171 Disease Relevance 0 Pain Relevance 0.15
The acute effects of the monoamine releaser p-chloroamphetamine (pCA, 10 mg/kg, i.p.) on preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the anterior (A-STR) vs. posterior (P-STR) striatum were studied in rodents at postnatal days (PND) 10, 21 and 35.
Transcription (expression) of preprotachykinin in posterior associated with monoamine
14) Confidence 0.42 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9974171 Disease Relevance 0 Pain Relevance 0.15
Expression of preprotachykinin, prodynorphin, prosomatostatin, preproenkephalin and tyrosine hydroxylase mRNA was also measured [39], [47].
Transcription (Expression) of preprotachykinin
15) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.08 Pain Relevance 0.11
No change in the cellular abundance of preprotachykinin messenger RNA was observed in cells of the insular cortex or a small discrete population of large cells (208 +/- 27 microns2) in the ventral putamen.
Transcription (abundance) of preprotachykinin in putamen
16) Confidence 0.27 Published 1995 Journal Neuroscience Section Abstract Doc Link 8544992 Disease Relevance 0.51 Pain Relevance 0.08
NK1-dependent transcriptional regulatory elements
Transcription (transcriptional) of NK1
17) Confidence 0.25 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.62 Pain Relevance 0.25
Studies in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys and in parkinsonian patients show elevated preproenkephalin (PPE) mRNA levels, unaltered by chronic L-DOPA therapy, whereas preprotachykinin (PPT) mRNA levels are decreased by the lesion and corrected by L-DOPA.
Transcription (levels) of PPT associated with parkinson's disease
18) Confidence 0.19 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930741 Disease Relevance 0.40 Pain Relevance 0.19
PPT mRNA levels were decreased in the caudate and putamen of untreated MPTP monkeys compared with control animals, and this was observed in the middle and posterior parts of these brain areas.
Transcription (levels) of PPT in brain associated with parkinson's disease
19) Confidence 0.15 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930741 Disease Relevance 0.80 Pain Relevance 0.19
Elevated PPE and decreased PPT mRNA levels observed after MPTP exposure were corrected after treatment with cabergoline (0.25 mg/kg, every other day), a dose that had antiparkinsonian effects and did not give sustained dyskinesia.
Transcription (levels) of PPT associated with parkinson's disease and dyskinesias
20) Confidence 0.15 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930741 Disease Relevance 0.85 Pain Relevance 0.17

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