INT47243

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2010
Negated 4
Speculated 8
Reported most in Abstract
Documents 195
Total Number 209
Disease Relevance 58.05
Pain Relevance 108.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neurons 18
lamina 10
spinal cord 9
spinal 7
heart 5
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4255 100.00 Very High Very High Very High
dorsal root ganglion 588 100.00 Very High Very High Very High
agonist 366 100.00 Very High Very High Very High
Dorsal horn 287 100.00 Very High Very High Very High
Glutamate 161 100.00 Very High Very High Very High
Hyperalgesia 155 100.00 Very High Very High Very High
nMDA receptor 107 100.00 Very High Very High Very High
Neuropeptide 92 100.00 Very High Very High Very High
cytokine 85 100.00 Very High Very High Very High
Action potential 53 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 642 100.00 Very High Very High Very High
Hyperalgesia 235 100.00 Very High Very High Very High
Hypoxia 45 100.00 Very High Very High Very High
Hydrocephalus 22 100.00 Very High Very High Very High
Targeted Disruption 134 99.86 Very High Very High Very High
Diabetic Cardiomyopathies 421 99.82 Very High Very High Very High
Hypotension 12 99.64 Very High Very High Very High
Diabetes Mellitus 1299 99.52 Very High Very High Very High
INFLAMMATION 266 99.52 Very High Very High Very High
Hypertrophy 152 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKC activity and protein expression did not change when assessed 1 h after bolus i.t. morphine in naive rats.
Gene_expression (expression) of PKC associated with kinase c and morphine
1) Confidence 0.78 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.83
Expression of epsilon and gamma PKC and the contributions of these isozymes in formalin-induced nociception was examined in postnatal day 7, 15, and 21 rats. epsilonPKC expression in dorsal root ganglion neurons and gammaPKC expression in lamina II of the spinal cord increased from the first to the third postnatal week.
Gene_expression (expression) of gammaPKC in lamina associated with ganglion cysts, nociception, kinase c, root ganglion neuron and spinal cord
2) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14762097 Disease Relevance 0.45 Pain Relevance 0.55
Expression of epsilon and gamma PKC and the contributions of these isozymes in formalin-induced nociception was examined in postnatal day 7, 15, and 21 rats. epsilonPKC expression in dorsal root ganglion neurons and gammaPKC expression in lamina II of the spinal cord increased from the first to the third postnatal week.
Gene_expression (expression) of epsilonPKC in lamina associated with ganglion cysts, nociception, kinase c, root ganglion neuron and spinal cord
3) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14762097 Disease Relevance 0.45 Pain Relevance 0.55
Infusion of NMDA antagonist D-AP5 prevented both the thermal hyperalgesia and the increase in PKC gamma expression in PTX-treated rats.
Gene_expression (expression) of PKC associated with kinase c, thermal hyperalgesia and antagonist
4) Confidence 0.75 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.90 Pain Relevance 1.99
PTX-induced neuropathic pain syndrome is accompanied by increasing of EAAs, decreasing of IAA release, and a selective increasing of PKC gamma expression in the spinal cord.
Gene_expression (expression) of PKC in spinal cord associated with kinase c, syndrome, neuropathic pain, spinal cord and excitatory amino acid
5) Confidence 0.75 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.79 Pain Relevance 1.98
The latter observation led Sen et al, to propose that differential expression of PKC?
Gene_expression (expression) of PKC associated with kinase c
6) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.34
Real-time PCR analysis of total RNA for mRNA encoding Cox-2, AKR1B5, PGES, PGDH and PGE (2) -9-ketoreductase indicated that there were no significant differences in the expression of any of these genes as a functions of PKC?
Gene_expression (expression) of PKC associated with kinase c
7) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.27
The data support the overall hypothesis that down-regulating expression of PKC?
Gene_expression (expression) of PKC associated with kinase c
8) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.38
Culturing steroidogenic cells collected from the Day -6 CL spontaneously induced the expression of PKC?
Gene_expression (expression) of PKC associated with kinase c
9) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.20
The results obtained were unexpected; the prediction was that because of low expression of PKC?
Gene_expression (expression) of PKC associated with kinase c
10) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.15
II, and there was no reduction in the amounts of these isozyme proteins even at 96 h after transfection with PKC?
Gene_expression (transfection) of PKC associated with kinase c
11) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.54
Expression of PKC?
Gene_expression (Expression) of PKC associated with kinase c
12) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.20
The next day cells were transiently transfected with PKC?
Gene_expression (transfected) of PKC associated with kinase c
13) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.09
The expression of PKCmu and PKCbeta1, but not of other PKC isoforms, was also enhanced by butyrate treatment, suggesting the possibility that these two isoforms might contribute to the enhanced activity of rVR1.
Gene_expression (expression) of PKC
14) Confidence 0.75 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15471852 Disease Relevance 0.06 Pain Relevance 0.30
Additionally, there is evidence indicating that when bovine follicular theca cells are isolated and their luteinization is induced under in vitro tissue culture conditions, they express PKC?
Gene_expression (express) of PKC in theca cells associated with kinase c
15) Confidence 0.75 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.47
We previously reported that the levels of metabotropic glutamate 5 (mGlu5) receptor and phosphorylated-protein kinase C (PKC) were significantly increased in the spinal cord following chronic ethanol consumption.
Gene_expression (levels) of PKC in spinal cord associated with kinase c, glutamate and spinal cord
16) Confidence 0.71 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17349994 Disease Relevance 0.40 Pain Relevance 0.63
The aim of the present study was to examine the effect of intrathecal (i.t.) injection of pertussis toxin (PTX) on the nociceptive threshold and protein kinase C (PKC) expression in the rat spinal cord.
Gene_expression (expression) of PKC in spinal cord associated with nociception, kinase c, bordatella infection, spinal cord and intrathecal
17) Confidence 0.71 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.46 Pain Relevance 0.34
Infusion of the NMDA antagonist, D-AP5, prevented both the thermal hyperalgesia and the increase in PKCgamma isoform expression in PTX-treated rats, and had no effect on these values in nai;ve rats.
Gene_expression (expression) of PKCgamma isoform associated with thermal hyperalgesia and antagonist
18) Confidence 0.71 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.76 Pain Relevance 0.94
These results show that i.t. injection of PTX induced thermal hyperalgesia accompanied by a selective increase in PKCgamma expression in both the synaptosomal membrane and cytosolic fractions of the dorsal horn of the rat lumbar spinal cord, and both effects were inhibited by the NMDA receptor antagonist, D-AP5.
Gene_expression (expression) of PKCgamma in spinal cord associated with nmda receptor antagonist, thermal hyperalgesia, dorsal horn and spinal cord
19) Confidence 0.71 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.63 Pain Relevance 0.84
Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion.
Gene_expression (expression) of PKC in spinal associated with tolerance and morphine
20) Confidence 0.67 Published 2000 Journal Pain Section Title Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.54

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