INT4726

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 10.09
Pain Relevance 14.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (PPT1) Golgi apparatus (PPT1) cytosol (PPT1)
extracellular space (PPT1) protein modification process (PPT1) extracellular region (PPT1)
Anatomy Link Frequency
muscle 3
spinal cord 1
skin 1
PPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain threshold 61 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
Buprenorphine 45 99.92 Very High Very High Very High
tolerance 9 99.80 Very High Very High Very High
headache 11 99.56 Very High Very High Very High
Pain 34 98.68 Very High Very High Very High
Serotonin 5 98.36 Very High Very High Very High
Spinal cord 7 98.00 Very High Very High Very High
qutenza 5 97.88 Very High Very High Very High
epidural 33 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 86 100.00 Very High Very High Very High
Myalgia 20 99.68 Very High Very High Very High
Paroxysmal Hemicrania 7 99.56 Very High Very High Very High
Disease 7 99.42 Very High Very High Very High
Headache 4 99.36 Very High Very High Very High
Dyskinesias 7 99.30 Very High Very High Very High
Hyperalgesia 10 93.76 High High
Nociception 1 91.88 High High
Necrosis 2 50.00 Quite Low
Cancer 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in PPT levels was associated with the intensity and the duration of the pain symptoms, supporting a role of both peripheral and central sensitization mechanisms in this pain condition.


Negative_regulation (decrease) of PPT
1) Confidence 0.57 Published 2010 Journal Arthritis Care Res (Hoboken) Section Body Doc Link 20235189 Disease Relevance 0 Pain Relevance 0
In conclusion, the presence of dyskinesia in PD patients does not appear to decrease PPT.
Negative_regulation (decrease) of PPT associated with disease and dyskinesias
2) Confidence 0.57 Published 2007 Journal Parkinsonism Relat. Disord. Section Abstract Doc Link 16784881 Disease Relevance 1.45 Pain Relevance 0.24
The decrease of PPT found in this study can be related to the occurrence of muscle pain and headache reported by patients during orthodontic or other dental treatment.
Negative_regulation (decrease) of PPT in muscle associated with pain, pain threshold, headache and myalgia
3) Confidence 0.57 Published 1999 Journal Eur J Orthod Section Abstract Doc Link 10502902 Disease Relevance 0.88 Pain Relevance 0.88
PPT was found to be reduced in HC and CPH when separately compared to controls.
Negative_regulation (reduced) of PPT associated with headache
4) Confidence 0.57 Published 1994 Journal Headache Section Abstract Doc Link 7960734 Disease Relevance 1.22 Pain Relevance 1.18
PPT near the surgical incision decreased by 30% from the preoperative value and did not exceed the preoperative value throughout the study.
Negative_regulation (decreased) of PPT associated with pain threshold
5) Confidence 0.51 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780276 Disease Relevance 0.78 Pain Relevance 2.42
In the late period (more than 6 h after administration), PPT at the forehead maintained the level of preoperative value, whereas PPT near the surgical incision decreased by more than 25% from the preoperative value (P < 0.01).
Negative_regulation (decreased) of PPT associated with pain threshold
6) Confidence 0.51 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780276 Disease Relevance 0.74 Pain Relevance 1.99
PPT at two muscle belly sites was significantly decreased during DOMS.
Negative_regulation (decreased) of PPT in muscle associated with pain threshold and myalgia
7) Confidence 0.45 Published 2006 Journal Somatosens Mot Res Section Abstract Doc Link 17178545 Disease Relevance 1.15 Pain Relevance 0.87
Decreased PPT was also found between 1st and 2nd metatarsal on day 1.
Negative_regulation (Decreased) of PPT
8) Confidence 0.42 Published 2008 Journal Exp Brain Res Section Abstract Doc Link 18813917 Disease Relevance 0.98 Pain Relevance 1.20
Capsaicin administration (subcutaneously) during the early postnatal period increased latency in a hot-plate test, decreased SP and NKA levels, increased levels of PPT mRNAs, and did not affect SPR mRNA levels in the spinal cord.
Negative_regulation (decreased) of PPT in spinal cord associated with qutenza, spinal cord and substance p
9) Confidence 0.42 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1279124 Disease Relevance 0 Pain Relevance 1.09
The exercise protocol induced significant DOMS for up to 72 hours, as reflected by reduced PPT and increased VAS scores (p<0.001).
Negative_regulation (reduced) of PPT
10) Confidence 0.42 Published 2008 Journal Br J Sports Med Section Body Doc Link 17717057 Disease Relevance 0.06 Pain Relevance 0
The CET group did show a significant decrease in physiological reactivity (skin conductance) compared to PPT.
Negative_regulation (decrease) of PPT in skin
11) Confidence 0.41 Published 2007 Journal Psychother Psychosom Section Body Doc Link 17230050 Disease Relevance 0 Pain Relevance 0
In the larger dose buprenorphine epidural group, during the early period (up to 2 h after administration), PPT at the forehead increased by 30%-40%, while PPT near the surgical incision decreased by 10%-25% compared to the preoperative value (P < 0.01).
Negative_regulation (decreased) of PPT associated with pain threshold, epidural and buprenorphine
12) Confidence 0.38 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780276 Disease Relevance 0.84 Pain Relevance 2.09
Decreased PPT and PPTO were found on day 2, 7 days after day 1.
Negative_regulation (Decreased) of PPT associated with pain threshold and tolerance
13) Confidence 0.33 Published 2006 Journal Somatosens Mot Res Section Abstract Doc Link 17178545 Disease Relevance 0.90 Pain Relevance 0.82
Decreased PPT and increased muscle hardness did not correlate.
Negative_regulation (Decreased) of PPT in muscle associated with pain threshold
14) Confidence 0.33 Published 2006 Journal Somatosens Mot Res Section Abstract Doc Link 17178545 Disease Relevance 1.10 Pain Relevance 0.82
Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.
Negative_regulation (precursor) of PPT associated with serotonin and substance p
15) Confidence 0.18 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.58

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