INT4727

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Context Info
Confidence 0.47
First Reported 1981
Last Reported 2010
Negated 9
Speculated 6
Reported most in Abstract
Documents 60
Total Number 66
Disease Relevance 6.74
Pain Relevance 32.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
blood 4
small intestine 3
platelet 2
lymphocytes 2
spinal cord 2
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 287 100.00 Very High Very High Very High
Neuropeptide 94 100.00 Very High Very High Very High
Enkephalin 66 100.00 Very High Very High Very High
qutenza 58 100.00 Very High Very High Very High
narcan 49 100.00 Very High Very High Very High
agonist 45 100.00 Very High Very High Very High
Calcitonin gene-related peptide 41 100.00 Very High Very High Very High
Opioid 38 100.00 Very High Very High Very High
Spinal cord 23 100.00 Very High Very High Very High
tetrodotoxin 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sperm Disorder 15 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 11 99.64 Very High Very High Very High
Coronary Artery Disease 4 98.64 Very High Very High Very High
Pain 22 98.36 Very High Very High Very High
Cancer 5 98.32 Very High Very High Very High
Rheumatoid Arthritis 3 98.28 Very High Very High Very High
Low Back Pain 1 97.20 Very High Very High Very High
Enteropathy 1 96.68 Very High Very High Very High
INFLAMMATION 27 96.04 Very High Very High Very High
Arthropathy 2 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sum, we report that NK activity in lung lavage is similar to that found in blood and may be regulated by alveolar macrophages and that topical lidocaine inhibits NK activity, an effect which needs to be considered in studies of these cells from lung lavage.
Regulation (regulated) of NK in alveolar macrophages associated with lidocaine
1) Confidence 0.47 Published 1990 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 2266229 Disease Relevance 0 Pain Relevance 0.52
Tachykinin systems in the spinal cord and basal ganglia: influence of neonatal capsaicin treatment or dopaminergic intervention on levels of peptides, substance P-encoding mRNAs, and substance P receptor mRNA.
Regulation (influence) of substance P in basal ganglia associated with qutenza, substance p and spinal cord
2) Confidence 0.44 Published 1992 Journal J. Neurochem. Section Title Doc Link 1279124 Disease Relevance 0 Pain Relevance 1.06
Effect of neurokinin A on human temporal muscle blood flow.
Regulation (Effect) of neurokinin A in blood
3) Confidence 0.44 Published 1989 Journal Peptides Section Title Doc Link 2558365 Disease Relevance 0.08 Pain Relevance 0.08
We studied the effects of neurokinin A (NKA) and neurokinin B (NKB), the mammalian-derived tachykinins, on the electrical and ion transport properties of canine tracheal epithelium.
Regulation (effects) of neurokinin A in epithelium
4) Confidence 0.44 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 2833141 Disease Relevance 0 Pain Relevance 0
Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain.
Regulation (changes) of substance P in spinal cord associated with dynorphin, lasting pain, enkephalin, substance p and spinal cord
5) Confidence 0.44 Published 1997 Journal Acta Physiol. Scand. Section Title Doc Link 9429659 Disease Relevance 0.35 Pain Relevance 1.72
We hypothesize that inhibition of the enzyme enhances peptide-modulated (tachykinin and/or enkephalin) excitation in select neurons of the substantia nigra.
Regulation (peptide-modulated) of tachykinin in substantia nigra associated with substantia nigra and enkephalin
6) Confidence 0.44 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3480807 Disease Relevance 0 Pain Relevance 0.22
The effects of neurokinin A, neurokinin B, and eledoisin on substance P analysis.
Regulation (effects) of neurokinin associated with substance p
7) Confidence 0.44 Published 1991 Journal J Clin Monit Section Title Doc Link 1712834 Disease Relevance 0.26 Pain Relevance 0.68
The effects of neurokinin A, neurokinin B, and eledoisin on substance P analysis.
Regulation (effects) of neurokinin associated with substance p
8) Confidence 0.44 Published 1991 Journal J Clin Monit Section Title Doc Link 1712834 Disease Relevance 0.25 Pain Relevance 0.67
Tachykinins exert a potent contractile effect, independently of cholinergic nerves, via NK-1 and NK-2 receptors.
Regulation (effect) of NK-2 in nerves
9) Confidence 0.44 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1692976 Disease Relevance 0 Pain Relevance 0.40
SP and NKA exert their main effect on arterial vasomotor tone, whereas NKB is the only tachykinin producing marked dilation of the pulmonary vein.
Regulation (effect) of tachykinin in pulmonary vein associated with substance p
10) Confidence 0.44 Published 1989 Journal Life Sci. Section Abstract Doc Link 2481796 Disease Relevance 0.06 Pain Relevance 0.76
CONCLUSION: We conclude that neuropeptides such as neurokinin A and substance P do not directly contribute to the development of PIB after allergic reaction.


Neg (not) Regulation (contribute) of neurokinin A
11) Confidence 0.44 Published 1996 Journal Clin. Exp. Allergy Section Body Doc Link 9027444 Disease Relevance 0.07 Pain Relevance 0
We have now analysed in detail the cytoarchitectonic characteristics of VMpo and its relationship with immunoreactivity for calbindin, substance P and calcitonin gene-related peptide (CGRP) in the human thalamus.
Regulation (immunoreactivity) of substance P in thalamus associated with thalamus, calcitonin gene-related peptide and substance p
12) Confidence 0.44 Published 2000 Journal Brain Section Abstract Doc Link 10686182 Disease Relevance 0.16 Pain Relevance 0.49
Twenty microlitres of different pruritogenic substances [histamine, substance P, neurokinin A, neurokinin B, trypsin, platelet-activating factor (PAF) and serotonin] and saline as control were injected intradermally into the inflamed test sites and in corresponding non-treated sites on the opposite forearm.
Regulation (control) of neurokinin in platelet
13) Confidence 0.42 Published 2002 Journal Br. J. Dermatol. Section Body Doc Link 12000375 Disease Relevance 0.08 Pain Relevance 0
Twenty microlitres of different pruritogenic substances [histamine, substance P, neurokinin A, neurokinin B, trypsin, platelet-activating factor (PAF) and serotonin] and saline as control were injected intradermally into the inflamed test sites and in corresponding non-treated sites on the opposite forearm.
Regulation (control) of neurokinin in platelet
14) Confidence 0.42 Published 2002 Journal Br. J. Dermatol. Section Body Doc Link 12000375 Disease Relevance 0.08 Pain Relevance 0
Since lidocaine is used in lung lavage for topical anaesthesia in humans and to increase the cell yield in animals, we also sought to determine if it could affect NK activity.
Regulation (affect) of NK in lung associated with lidocaine
15) Confidence 0.41 Published 1990 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 2266229 Disease Relevance 0.07 Pain Relevance 0.48
To determine the roles of endogenously released tachykinins (substance P [SP] and neurokinin A [NKA]) in the human bronchial tissues, we studied the effects of tachykinin antagonist FK224 on bronchial smooth muscle contraction induced by SP, NKA and capsaicin in an organ bath.
Regulation (effects) of tachykinin in smooth muscle associated with qutenza, antagonist and substance p
16) Confidence 0.38 Published 1997 Journal Fundam Clin Pharmacol Section Abstract Doc Link 9243258 Disease Relevance 0 Pain Relevance 0.42
The functional assay based on aequorin-derived luminescence triggered by receptor-mediated changes in Ca2+ levels was used to compare the effect of spantides I-III on SP-, NKA- and NKB-stimulated NK1, NK2 and NK3 receptors, respectively.
Regulation (effect) of NK2
17) Confidence 0.35 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15990182 Disease Relevance 0 Pain Relevance 0.16
From the Schild analyses, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P, a potent substance P antagonist, competitively antagonized the response to substance P, had no significant effect on the response to neurokinin beta, and antagonized the response to neurokinin alpha and eledoisin in a more complex manner.
Regulation (response) of neurokinin alpha associated with antagonist and substance p
18) Confidence 0.26 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2438560 Disease Relevance 0 Pain Relevance 0.54
IMPLICATIONS: We investigated the effects of IV anesthetics on substance P receptors (SPR) expressed in Xenopus oocytes.
Spec (investigated) Regulation (effects) of substance P in oocytes associated with substance p
19) Confidence 0.26 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12818951 Disease Relevance 0 Pain Relevance 0.72
The individual demand for pethidine was related to individual levels of fraction I endorphins and substance P-like immunoreactivity in the cerebrospinal fluid (CSF).
Regulation (immunoreactivity) of substance P in CSF associated with algil and substance p
20) Confidence 0.26 Published 1982 Journal Pain Section Abstract Doc Link 6181455 Disease Relevance 0.09 Pain Relevance 1.00

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