INT4728

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (PPT1) Golgi apparatus (PPT1) cytosol (PPT1)
extracellular space (PPT1) protein modification process (PPT1) extracellular region (PPT1)
Anatomy Link Frequency
spinal cord 2
PPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 100 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
opioid receptor 14 99.68 Very High Very High Very High
antagonist 18 99.04 Very High Very High Very High
narcan 7 98.60 Very High Very High Very High
Spinal cord 7 98.00 Very High Very High Very High
qutenza 5 97.88 Very High Very High Very High
Substantia nigra 1 90.28 High High
Morphine 8 88.16 High High
Dynorphin 1 81.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 1 83.96 Quite High
Neuropathy 1 76.88 Quite High
Diabetic Neuropathy 1 76.12 Quite High
Pancreatitis 3 54.56 Quite High
Pain 4 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin administration (subcutaneously) during the early postnatal period increased latency in a hot-plate test, decreased SP and NKA levels, increased levels of PPT mRNAs, and did not affect SPR mRNA levels in the spinal cord.
Negative_regulation (decreased) of Neg (not) Positive_regulation (increased) of PPT in spinal cord associated with qutenza, spinal cord and substance p
1) Confidence 0.42 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1279124 Disease Relevance 0 Pain Relevance 1.09
The increase of PPT due to tramadol could to a large extent be prevented by the opioid receptor antagonist naloxone, and the inhibition due to O-desmethyltramadol was in fact attenuated by 90 %.
Negative_regulation (prevented) of Positive_regulation (increase) of PPT associated with tramadol, antagonist, narcan and opioid receptor
2) Confidence 0.34 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0.29 Pain Relevance 1.98

General Comments

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