INT4729

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 19
Total Number 31
Disease Relevance 7.11
Pain Relevance 17.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (PPT1) Golgi apparatus (PPT1) cytosol (PPT1)
extracellular space (PPT1) protein modification process (PPT1) extracellular region (PPT1)
Anatomy Link Frequency
caudate nucleus 1
muscle 1
Knee joint 1
spinal cord 1
finger 1
PPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain threshold 48 100.00 Very High Very High Very High
referred pain 3 99.80 Very High Very High Very High
Serotonin 28 99.76 Very High Very High Very High
antagonist 204 99.74 Very High Very High Very High
tramadol 1100 99.68 Very High Very High Very High
substance P 18 99.66 Very High Very High Very High
Pain 63 99.28 Very High Very High Very High
epidural 11 98.68 Very High Very High Very High
adenocard 2 98.64 Very High Very High Very High
Buprenorphine 15 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 111 100.00 Very High Very High Very High
Referred Pain 3 99.80 Very High Very High Very High
Parkinson's Disease 8 99.66 Very High Very High Very High
Dyskinesias 18 90.92 High High
Cancer 11 83.96 Quite High
Pancreatitis 37 77.44 Quite High
Osteoarthritis 13 77.04 Quite High
Neuropathy 11 76.88 Quite High
Diabetic Neuropathy 11 76.12 Quite High
Hyperalgesia 11 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin administration (subcutaneously) during the early postnatal period increased latency in a hot-plate test, decreased SP and NKA levels, increased levels of PPT mRNAs, and did not affect SPR mRNA levels in the spinal cord.
Neg (not) Positive_regulation (increased) of PPT in spinal cord associated with qutenza, spinal cord and substance p
1) Confidence 0.67 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1279124 Disease Relevance 0 Pain Relevance 1.08
The results showed that ICB, which mainly blocks large-diameter myelinated muscle afferents, was associated with an increase in PPT and PTRP (all P < 0.001) at MTrP regions but not at non-MTrP regions.
Positive_regulation (increase) of PPT in muscle associated with pain threshold and referred pain
2) Confidence 0.67 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 20035322 Disease Relevance 0.83 Pain Relevance 1.01
CONCLUSION: Various types of physical and mental stressors significantly increased PPT and PTOL readings in young female adults, in addition to the significant findings that students with higher body mass indices tolerated pain less.


Positive_regulation (increased) of PPT in body
3) Confidence 0.67 Published 2009 Journal Saudi Med J Section Body Doc Link 19370271 Disease Relevance 0.05 Pain Relevance 0
EA at 3Hz (15 minutes) also induced PPT elevations immediately and for one hour after EA compared to the control group.
Positive_regulation (induced) of PPT
4) Confidence 0.67 Published 2007 Journal Acupunct Med Section Body Doc Link 17906601 Disease Relevance 0.13 Pain Relevance 0
However, no other variety of EA significantly increased PPT.
Positive_regulation (increased) of PPT
5) Confidence 0.67 Published 2007 Journal Acupunct Med Section Body Doc Link 17906601 Disease Relevance 0.12 Pain Relevance 0
EA at 3Hz (60 minutes) resulted in significant increases of PPT which persisted for 24 hours after injection.
Positive_regulation (increases) of PPT
6) Confidence 0.67 Published 2007 Journal Acupunct Med Section Body Doc Link 17906601 Disease Relevance 0.14 Pain Relevance 0
Knee joint mobilization also increased PPT at a distal, non-painful site and reduced 'up and go' time significantly more (-5% (-9.3 to 0.8)) than manual contact (-0.4% (-4.2 to 3.5)) or no-contact control (+7.9% (2.6-13.2)) interventions.
Positive_regulation (increased) of PPT in Knee joint associated with pain and pain threshold
7) Confidence 0.67 Published 2007 Journal Man Ther Section Abstract Doc Link 16777467 Disease Relevance 0.87 Pain Relevance 0.85
Subcutaneous lignocaine significantly elevated PPT compared to placebo.
Positive_regulation (elevated) of PPT associated with pain threshold
8) Confidence 0.67 Published 1986 Journal Pain Section Abstract Doc Link 3748589 Disease Relevance 0.91 Pain Relevance 0.84
In addition, mean malleolar VPT and PPT to heat and cold stimuli on the thenar and the foot were significantly elevated in group 2 as compared to group 1 (p less than 0.05).
Positive_regulation (elevated) of PPT in foot
9) Confidence 0.67 Published 1988 Journal Klin. Wochenschr. Section Abstract Doc Link 2853250 Disease Relevance 0.14 Pain Relevance 0.07
CONCLUSION: This study shows that absolute PPT levels in healthy individuals change significantly during consecutive PPT recordings, as well as over a 6-month period; this limits the usefulness of such measurements.
Positive_regulation (change) of PPT
10) Confidence 0.49 Published 2000 Journal J Orofac Pain Section Body Doc Link 11203752 Disease Relevance 0 Pain Relevance 0
In the present study, in situ hybridization histochemistry was used to investigate the effect of chronic L-DOPA administration on the activity of the direct and indirect striatal output pathways by measuring striatal preprotachykinin (PPT), preproenkephalin-A (PPE-A) and adenosine-2a (A2a) receptor gene expression in these monkeys.
Spec (investigate) Positive_regulation (measuring) of PPT associated with adenocard
11) Confidence 0.49 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10762340 Disease Relevance 0.53 Pain Relevance 0.09
An increase of PPE and PPD mRNA levels was observed in anterior caudate nucleus of L-DOPA treated MPTP monkeys compared to controls and to Saline-treated MPTP monkeys whereas PPT-A mRNA levels were unchanged.
Neg (unchanged) Positive_regulation (unchanged) of PPT in caudate nucleus associated with parkinson's disease
12) Confidence 0.45 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 19576910 Disease Relevance 1.17 Pain Relevance 0.25
Post hoc analyses found that (a) both experimental groups showed greater improvements in PPT than the placebo group (P < .05), without significant differences between them (P > .6); (b) the right side had greater increases in PPT in both experimental groups (P < .05), but not within the placebo group (P > .8); (c) men experienced greater increases in PPT levels than women, particularly in the experimental nondominant group (P < .01).
Positive_regulation (increases) of PPT
13) Confidence 0.45 Published 2008 Journal J Manipulative Physiol Ther Section Body Doc Link 18558274 Disease Relevance 0 Pain Relevance 0
During the cold-induced pain, a significant PPT elevation was found at all test sites in men (P < .023) and at all sites (P < .021) except for the finger in women.
Positive_regulation (elevation) of PPT in finger
14) Confidence 0.45 Published 2010 Journal J Orofac Pain Section Body Doc Link 20664826 Disease Relevance 0 Pain Relevance 0
Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.
Positive_regulation (increased) of PPT associated with serotonin and substance p
15) Confidence 0.45 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.58
EA at 3Hz (15 minutes) also induced PPT elevations immediately and for one hour after EA compared to the control group.
Positive_regulation (elevations) of PPT
16) Confidence 0.45 Published 2007 Journal Acupunct Med Section Body Doc Link 17906601 Disease Relevance 0.13 Pain Relevance 0
In the larger dose buprenorphine epidural group, during the early period (up to 2 h after administration), PPT at the forehead increased by 30%-40%, while PPT near the surgical incision decreased by 10%-25% compared to the preoperative value (P < 0.01).
Positive_regulation (increased) of PPT associated with pain threshold, epidural and buprenorphine
17) Confidence 0.41 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780276 Disease Relevance 0.94 Pain Relevance 2.12
The increase of PPT due to tramadol could to a large extent be prevented by the opioid receptor antagonist naloxone, and the inhibition due to O-desmethyltramadol was in fact attenuated by 90 %.
Positive_regulation (increase) of PPT associated with tramadol, antagonist, narcan and opioid receptor
18) Confidence 0.41 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0.29 Pain Relevance 1.90
In conclusion, the results of this study showed that oral administration of the 5-HT3-antagonist granisetron increased the PPT over healthy trunk and limb muscles but not over orofacial muscles, and that the response in the limb muscles was greater in males.
Neg (not) Positive_regulation (increased) of PPT in limb muscles associated with pain threshold and antagonist
19) Confidence 0.39 Published 2005 Journal Pain Section Abstract Doc Link 15661432 Disease Relevance 0.71 Pain Relevance 0.98
The mean increase of PPT due to 100 ?
Positive_regulation (increase) of PPT
20) Confidence 0.35 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0 Pain Relevance 0.92

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