INT47298

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Context Info
Confidence 0.79
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.77
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl)
vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)
Anatomy Link Frequency
vesicle 4
epidermal cells 2
brain 2
Macrophages 1
basal cells 1
Ctsl (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 14 99.84 Very High Very High Very High
Enkephalin 15 98.92 Very High Very High Very High
Arthritis 108 98.66 Very High Very High Very High
metalloproteinase 14 98.52 Very High Very High Very High
Opioid 5 98.48 Very High Very High Very High
lidocaine 5 98.22 Very High Very High Very High
Neurotransmitter 9 97.88 Very High Very High Very High
Neuropeptide 12 97.72 Very High Very High Very High
antagonist 7 97.72 Very High Very High Very High
Pain 3 94.48 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 14 100.00 Very High Very High Very High
Emphysema 20 99.44 Very High Very High Very High
Cancer 19 98.98 Very High Very High Very High
Arthritis 112 98.66 Very High Very High Very High
Pain 4 94.48 High High
Neurodegenerative Disease 6 92.64 High High
Rheumatoid Arthritis 62 88.36 High High
Disease 22 87.04 High High
Alzheimer's Dementia 2 82.72 Quite High
Pulmonary Disease 1 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MEP is synthesized and secreted at low levels by cultured epidermal basal cells.
Localization (secreted) of MEP in basal cells
1) Confidence 0.79 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.17 Pain Relevance 0.08
Moreover, cathepsin L in brain cortical neurons was colocalized with dynorphins in secretory vesicles, the primary site of neuropeptide production.
Localization (colocalized) of cathepsin L in brain associated with neuropeptide
2) Confidence 0.70 Published 2010 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19837164 Disease Relevance 0.32 Pain Relevance 0.55
Cathepsin L knockout mouse brains showed extensive decreases in dynorphin A, dynorphin B, and alpha-neoendorphin that were reduced by 75%, 83%, and 90%, respectively, compared to controls.
Localization (decreases) of Cathepsin L in brains associated with targeted disruption and dynorphin
3) Confidence 0.70 Published 2010 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19837164 Disease Relevance 0.29 Pain Relevance 0.56
The phorbol ester antagonists retinoic acid, lidocaine and fluocinolone acetonide were examined to determine their effect on the synthesis and secretion of MEP.
Localization (secretion) of MEP associated with antagonist and lidocaine
4) Confidence 0.60 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.14 Pain Relevance 0.15
The effect of tumor promoters and anti-promoters on the synthesis and secretion of a 35,000 mol wt transformation-dependent secreted glycoprotein (MEP) by primary mouse epidermal cells has been investigated.
Localization (secreted) of MEP in epidermal cells associated with cancer
5) Confidence 0.60 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.17 Pain Relevance 0
The effect of tumor promoters and anti-promoters on the synthesis and secretion of a 35,000 mol wt transformation-dependent secreted glycoprotein (MEP) by primary mouse epidermal cells has been investigated.
Localization (secretion) of MEP in epidermal cells associated with cancer
6) Confidence 0.60 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.17 Pain Relevance 0
This increase is maximal 6 h after treatment and parallels an increase in secretion of MEP measured by appearance of radiolabeled protein in the medium or by radioimmunoassay of culture supernatants.
Localization (secretion) of MEP
7) Confidence 0.60 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.15 Pain Relevance 0.12
Importantly, cathespin L expression was directed to secretory vesicles, demonstrated by colocalization of cathepsin L-DsRed fusion protein with enkephalin and chromogranin A neuropeptides that are present in secretory vesicles.
Localization (colocalization) of cathepsin L in vesicles associated with neuropeptide and enkephalin
8) Confidence 0.50 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 1.15
In this review, evidence for secretory vesicle cathepsin L and Arg/Lys aminopeptidase as a distinct proteolytic pathway for processing the prohormone proenkephalin is presented.
Localization (secretory) of cathepsin L in vesicle
9) Confidence 0.20 Published 2004 Journal Biol. Chem. Section Abstract Doc Link 15255178 Disease Relevance 0 Pain Relevance 0.22
Secretory vesicle cathepsin L participates in the proteolytic conversion of proenkephalin into the active enkephalin, an opioid peptide neurotransmitter that mediates pain relief.
Localization (Secretory) of cathepsin L in vesicle associated with pain, neurotransmitter, enkephalin and opioid
10) Confidence 0.14 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 17081116 Disease Relevance 0.41 Pain Relevance 0.38
Macrophages release two classes of elastolytic enzymes: cysteine proteinases (cathepsin L and cathepsin S) and several matrix metalloproteinases (MMPs).
Localization (release) of cathepsin L in Macrophages associated with metalloproteinase
11) Confidence 0.11 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695612 Disease Relevance 0.68 Pain Relevance 0.17
These investigations have identified secretory vesicle cathepsin L for the production of the enkephalin opioid peptide neurotransmitter and other neuropeptides.
Localization (secretory) of cathepsin L in vesicle associated with neurotransmitter, neuropeptide, enkephalin and opioid
12) Confidence 0.06 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16724274 Disease Relevance 0.47 Pain Relevance 0.41
Other molecules that have been demonstrated to play a role in arthritis using gene transfer in various in vitro or animal models are Csk, cathepsin L, fibronectin, galectin-1, p16INK4A, p21Cip1, SOCS3, soluble CR1, superoxide dismutase and catalase, Ras, and prothymosin ?
Localization (galectin-1) of cathepsin L associated with arthritis
13) Confidence 0.02 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.79 Pain Relevance 0.29

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