INT47301

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Context Info
Confidence 0.76
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 7.72
Pain Relevance 9.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl)
vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)
Anatomy Link Frequency
vesicle 4
muscles 2
epidermal cells 1
cartilage 1
skin 1
Ctsl (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 74 100.00 Very High Very High Very High
Opioid 9 99.24 Very High Very High Very High
Neuropeptide 30 99.12 Very High Very High Very High
rheumatoid arthritis 248 98.90 Very High Very High Very High
Neurotransmitter 16 98.84 Very High Very High Very High
Arthritis 129 98.66 Very High Very High Very High
lidocaine 6 98.50 Very High Very High Very High
Nicotine 6 98.32 Very High Very High Very High
antagonist 14 98.00 Very High Very High Very High
metalloproteinase 147 91.64 High High
Disease Link Frequency Relevance Heat
Overactive Bladder 61 100.00 Very High Very High Very High
Cancer 66 99.26 Very High Very High Very High
Rheumatoid Arthritis 248 98.90 Very High Very High Very High
Arthritis 131 98.66 Very High Very High Very High
Bladder Cancer 5 98.64 Very High Very High Very High
Severe Combined Immunodeficiency 32 98.52 Very High Very High Very High
Neurodegenerative Disease 7 98.48 Very High Very High Very High
Disease 78 94.52 High High
Apoptosis 107 91.68 High High
INFLAMMATION 175 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these agents, only fluocinolone acetonide affects MEP levels by suppressing the basal level of MEP synthesis but not its relative induction by TPA.
Gene_expression (synthesis) of MEP
1) Confidence 0.76 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.13 Pain Relevance 0.14
MEP is synthesized and secreted at low levels by cultured epidermal basal cells.
Gene_expression (synthesized) of MEP in basal cells
2) Confidence 0.76 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.17 Pain Relevance 0.08
Cellular coexpression of cathepsin L with prodynorphin in PC12 cells resulted in increased production of dynorphins A and B.
Gene_expression (coexpression) of cathepsin L
3) Confidence 0.73 Published 2010 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19837164 Disease Relevance 0.33 Pain Relevance 0.52
These data suggest that the modifying effects of these three agents on tumor promotion are not mediated via an alteration in MEP synthesis per se is not sufficient for promotion.
Gene_expression (synthesis) of MEP associated with cancer
4) Confidence 0.66 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.23 Pain Relevance 0.13
The phorbol ester antagonists retinoic acid, lidocaine and fluocinolone acetonide were examined to determine their effect on the synthesis and secretion of MEP.
Gene_expression (synthesis) of MEP associated with antagonist and lidocaine
5) Confidence 0.66 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.14 Pain Relevance 0.15
An increase in MEP synthesis is also observed in the skin of mice exposed to TPA.
Gene_expression (synthesis) of MEP in skin
6) Confidence 0.66 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.15 Pain Relevance 0.14
RESULTS: The amplitudes of p-MEP were significantly higher in all muscle recording sites than those of c-MEP in patients without motor deficits, whereas these amplitudes were significantly higher in only four of the eight muscles in patients with motor deficits (P < 0.05).
Gene_expression (higher) of MEP in muscles
7) Confidence 0.66 Published 2009 Journal J Anesth Section Body Doc Link 19444553 Disease Relevance 0 Pain Relevance 0
RESULTS: The amplitudes of p-MEP were significantly higher in all muscle recording sites than those of c-MEP in patients without motor deficits, whereas these amplitudes were significantly higher in only four of the eight muscles in patients with motor deficits (P < 0.05).
Gene_expression (higher) of MEP in muscles
8) Confidence 0.58 Published 2009 Journal J Anesth Section Body Doc Link 19444553 Disease Relevance 0 Pain Relevance 0
There were no statistically significant differences in success rates between c-MEP and p-MEP recording.
Gene_expression (recording) of MEP
9) Confidence 0.58 Published 2009 Journal J Anesth Section Body Doc Link 19444553 Disease Relevance 0 Pain Relevance 0
There were no statistically significant differences in success rates between c-MEP and p-MEP recording.
Gene_expression (recording) of MEP
10) Confidence 0.58 Published 2009 Journal J Anesth Section Body Doc Link 19444553 Disease Relevance 0 Pain Relevance 0
The effect of tumor promoters and anti-promoters on the synthesis and secretion of a 35,000 mol wt transformation-dependent secreted glycoprotein (MEP) by primary mouse epidermal cells has been investigated.
Gene_expression (synthesis) of MEP in epidermal cells associated with cancer
11) Confidence 0.52 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.17 Pain Relevance 0
Expression of cathepsin L resulted in highly increased cellular levels of (Met)enkephalin, resulting from the conversion of PE to enkephalin-containing intermediates of 23, 18-19, 8-9, and 4.5 kDa that were similar to those present in vivo.
Gene_expression (Expression) of cathepsin L associated with enkephalin
12) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.76
The newly defined secretory vesicle function of cathepsin L for biosynthesis of active enkephalin opioid peptide contrasts with its function in lysosomes for protein degradation.
Gene_expression (biosynthesis) of cathepsin L in vesicle associated with enkephalin and opioid
13) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 1.13
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
Gene_expression (expression) of Cathepsin L in vesicles associated with neuropeptide and enkephalin
14) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.92
These findings were achieved by coexpression of PE and cathepsin L cDNAs in PC12 cells with analyses of PE-derived peptide products.
Gene_expression (coexpression) of cathepsin L
15) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.68
Furthermore, expression of cathepsin L with PE resulted in increased amounts of nicotine-induced secretion of (Met)enkephalin.
Gene_expression (expression) of cathepsin L associated with nicotine and enkephalin
16) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 1.00
In addition to ctsl, the detrusor also presents ctsh under the control of c-Myb.
Gene_expression (presents) of ctsl associated with overactive bladder
17) Confidence 0.50 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.63 Pain Relevance 0
This study demonstrates the novel cellular role of the cysteine protease cathepsin L for producing the (Met)enkephalin peptide neurotransmitter from proenkephalin (PE) in the regulated secretory pathway of neuroendocrine PC12 cells.
Gene_expression (producing) of cathepsin L associated with neurotransmitter and enkephalin
18) Confidence 0.40 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.57
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.
Gene_expression (biosynthesis) of cathepsin L in vesicles associated with neurodegenerative disease
19) Confidence 0.15 Published 2006 Journal Biol. Chem. Section Title Doc Link 17081116 Disease Relevance 0.41 Pain Relevance 0.33
The oncogene ras is predominantly expressed in the synovial lining layer associated with expression of the proteolytic enzyme cathepsin L at sites of invasive growth.
Gene_expression (expression) of cathepsin L
20) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.07 Pain Relevance 0.19

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