INT47302

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Context Info
Confidence 0.53
First Reported 1981
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 0.54
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl)
vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)
Anatomy Link Frequency
epidermal cells 2
vesicles 2
Ctsl (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 24 100.00 Very High Very High Very High
Neurotransmitter 4 98.84 Very High Very High Very High
lidocaine 3 98.78 Very High Very High Very High
Neuropeptide 8 98.48 Very High Very High Very High
antagonist 3 98.28 Very High Very High Very High
Nicotine 2 63.64 Quite High
Opioid 2 40.44 Quite Low
Disease Link Frequency Relevance Heat
Cancer 9 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phorbol ester antagonists retinoic acid, lidocaine and fluocinolone acetonide were examined to determine their effect on the synthesis and secretion of MEP.
Spec (determine) Regulation (effect) of Gene_expression (synthesis) of MEP associated with antagonist and lidocaine
1) Confidence 0.53 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.14 Pain Relevance 0.15
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
Regulation (directed) of Gene_expression (expression) of Cathepsin L in vesicles associated with neuropeptide and enkephalin
2) Confidence 0.30 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.92
These data suggest that the modifying effects of these three agents on tumor promotion are not mediated via an alteration in MEP synthesis per se is not sufficient for promotion.
Regulation (alteration) of Gene_expression (synthesis) of MEP associated with cancer
3) Confidence 0.23 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.23 Pain Relevance 0.13
The effect of tumor promoters and anti-promoters on the synthesis and secretion of a 35,000 mol wt transformation-dependent secreted glycoprotein (MEP) by primary mouse epidermal cells has been investigated.
Spec (investigated) Regulation (effect) of Gene_expression (synthesis) of MEP in epidermal cells associated with cancer
4) Confidence 0.23 Published 1981 Journal Carcinogenesis Section Abstract Doc Link 7296764 Disease Relevance 0.17 Pain Relevance 0
This study demonstrates the novel cellular role of the cysteine protease cathepsin L for producing the (Met)enkephalin peptide neurotransmitter from proenkephalin (PE) in the regulated secretory pathway of neuroendocrine PC12 cells.
Regulation (role) of Gene_expression (producing) of cathepsin L associated with neurotransmitter and enkephalin
5) Confidence 0.18 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.58

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