INT47343

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Context Info
Confidence 0.65
First Reported 1981
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.66
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Rnase1)
Anatomy Link Frequency
plasma 3
Rnase1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 98.08 Very High Very High Very High
Glutamate receptor 1 66.72 Quite High
Morphine 1 25.00 Low Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 27 100.00 Very High Very High Very High
Pancreatitis 17 98.64 Very High Very High Very High
Malignant Neoplastic Disease 7 96.92 Very High Very High Very High
Disease 4 95.68 Very High Very High Very High
Renal Insufficiency 1 92.60 High High
Metastasis 2 88.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 88.00 High High
Viral Infection 1 72.52 Quite High
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless increased "plasma" RNase activity was also found in 18/43 patients with chronic pancreatitis, as well as in the majority of the non-pancreatic malignant tumors studied.
Positive_regulation (increased) of RNase in plasma associated with malignant neoplastic disease and chronic pancreatitis
1) Confidence 0.65 Published 1981 Journal Hepatogastroenterology Section Abstract Doc Link 7345012 Disease Relevance 0.90 Pain Relevance 0.29
A significant increase of "plasma" RNase was found in pancreatic cancer (p less than 0.01) as compared with controls, non-calcifying chronic pancreatitis (p less than 0.01), calcifying chronic pancreatitis (p less than 0.01), and chronic recurrent pancreatitis (p less than 0.01).
Positive_regulation (increase) of RNase in plasma associated with pancreatitis, pancreatic cancer and chronic pancreatitis
2) Confidence 0.57 Published 1981 Journal Hepatogastroenterology Section Abstract Doc Link 7345012 Disease Relevance 0.85 Pain Relevance 0.26
These data suggest that increased "plasma" RNase, although very frequent in pancreatic cancer, is not a marker of pancreatic malignancy.
Positive_regulation (increased) of RNase in plasma associated with malignant neoplastic disease and pancreatic cancer
3) Confidence 0.57 Published 1981 Journal Hepatogastroenterology Section Abstract Doc Link 7345012 Disease Relevance 1.03 Pain Relevance 0.26
RNase resistance is afforded by the inclusion of RNase inhibitors during steps in which mRNA is vulnerable to RNase digestion, alleviating the need to maintain RNase-free conditions during experiments.
Positive_regulation (vulnerable) of RNase
4) Confidence 0.50 Published 1996 Journal J. Neurosci. Methods Section Abstract Doc Link 8815311 Disease Relevance 0 Pain Relevance 0.03
The serum RNase activity in pancreatic cancer patients did not show any significant increase in comparison to the other groups, and these patients could not be distinguished from those with the other diseases when excluding other factors influencing serum RNase level such as: Renal insufficiency, nutrition, age, sex.
Positive_regulation (increase) of RNase associated with renal insufficiency, pancreatic cancer and disease
5) Confidence 0.36 Published 1981 Journal Klin. Wochenschr. Section Abstract Doc Link 7311390 Disease Relevance 1.38 Pain Relevance 0.17
Cellular delivery systems based on conjugates of streptavidin (SA) and the OX26 monoclonal antibody directed to the transferrin receptor may be employed as a universal carrier for the transport of mono-biotinylated peptides, ODNs, or PNAs. 3'-Biotinylation of phosphodiester (PO)-ODN produces complete protection of ODN against serum and cellular 3'-exonucleases, facilitating the conjugation to avidin-based delivery systems and maintaining the activation of RNase H.
Positive_regulation (activation) of RNase
6) Confidence 0.05 Published 1998 Journal J Pharm Sci Section Abstract Doc Link 9811482 Disease Relevance 0.49 Pain Relevance 0

General Comments

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