INT47348

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Context Info
Confidence 0.37
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.24
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl4) extracellular region (Ccl4)
Anatomy Link Frequency
liver 2
neutrophil 1
Ccl4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 28 100.00 Very High Very High Very High
Paracetamol 9 100.00 Very High Very High Very High
rheumatoid arthritis 1 98.36 Very High Very High Very High
agonist 1 97.40 Very High Very High Very High
alcohol 13 94.44 High High
antagonist 9 85.16 High High
Inflammation 28 52.88 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 76 100.00 Very High Very High Very High
Hepatotoxicity 20 100.00 Very High Very High Very High
Toxicity 17 99.96 Very High Very High Very High
Cancer 5 99.20 Very High Very High Very High
Diabetes Mellitus 3 98.76 Very High Very High Very High
Rheumatoid Arthritis 1 98.36 Very High Very High Very High
Hypoxia 2 98.28 Very High Very High Very High
Stroke 1 97.48 Very High Very High Very High
Coronary Artery Disease 1 97.16 Very High Very High Very High
Body Weight 44 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNP-induced hypoxia resulting in an accelerated metabolic activation of CCl4 presumably accounts for the interaction between DNP and CCl4.
CCl4 Binding (interaction) of associated with hypoxia
1) Confidence 0.37 Published 1981 Journal Toxicol. Lett. Section Abstract Doc Link 7314128 Disease Relevance 0.17 Pain Relevance 0.14
In response to hepatocellular injury initiated by the biotransformation of CCl4 to reactive radicals, "activated" Kupffer cells in liver respond by releasing increased amounts of active oxygen species and other bioactive agents [26].
CCl4 Binding (biotransformation) of in liver associated with injury
2) Confidence 0.37 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.39 Pain Relevance 0
The probable mechanism by which the root extract exerts its protective action against CCl4-induced hepatocellular metabolic alterations could be by the stimulation of hepatic regeneration through an improved synthesis of protein or interference with the microsomal activation of CCl4 and/or its accelerated detoxification and excretion.
CCl4 Binding (action) of
3) Confidence 0.36 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996063 Disease Relevance 0.27 Pain Relevance 0
The basis of CCl4 hepatotoxicity lies in its biotransformation by the cytochrome P-450 system to two free radicals.
CCl4 Binding (biotransformation) of associated with hepatotoxicity
4) Confidence 0.32 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 1.25 Pain Relevance 0.08
In conclusion, the results of the present study indicate that orally administered octacosanol attenuates disrupted hepatic ROS metabolism associated with acute liver injury progression in rats intoxicated with CCl4 through its antioxidant action and its inhibitory action on neutrophil infiltration.
CCl4 Binding (associated) of in neutrophil associated with injury
5) Confidence 0.31 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.43 Pain Relevance 0.04
In our opinion, CCl4 partially protects against paracetamol-induced liver injury by interacting with enzymes which are responsible for the biotransformation of PRCT to a reactive arylating species that bind to cell molecules.
CCl4 Binding (interacting) of in liver associated with paracetamol and injury
6) Confidence 0.31 Published 1980 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 7470301 Disease Relevance 0.23 Pain Relevance 0.31
Assessment of these genes revealed an association with the known or suspected genes involved in the biology of CCl4 toxicity.
CCl4 Binding (association) of associated with toxicity
7) Confidence 0.28 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.33 Pain Relevance 0
Furthermore, vMIP-II inhibits the chemotactic activity of the rat chemokines CCL2 (MCP-1), CCL4 (MIP-1?)
CCL4 Binding (activity) of associated with chemokine
8) Confidence 0.25 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.18 Pain Relevance 0.52

General Comments

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