INT47349

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Context Info
Confidence 0.49
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.92
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl4) extracellular region (Ccl4)
Ccl4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 2 98.64 Very High Very High Very High
Paracetamol 2 97.44 Very High Very High Very High
Inflammation 7 63.20 Quite High
Pain 2 46.16 Quite Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 1 100.00 Very High Very High Very High
Apoptosis 19 99.32 Very High Very High Very High
Renal Disease 6 97.68 Very High Very High Very High
Injury 21 92.24 High High
Stress 36 88.56 High High
Death 8 81.36 Quite High
Hepatotoxicity 15 68.64 Quite High
INFLAMMATION 9 63.20 Quite High
Cancer 2 61.12 Quite High
Pain 4 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extensive evidence demonstrates that as a result of the metabolic activation of CCl4, •CCl4 and •Cl, are formed which initiate lipid peroxidation process.
Positive_regulation (result) of Positive_regulation (activation) of CCl4
1) Confidence 0.49 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.43 Pain Relevance 0
Extensive evidence demonstrates that as a result of the metabolic activation of CCl4, •CCl4 and •Cl, are formed which initiate lipid peroxidation process.
Positive_regulation (result) of Positive_regulation (activation) of CCl4
2) Confidence 0.49 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.43 Pain Relevance 0
DNP-induced hypoxia resulting in an accelerated metabolic activation of CCl4 presumably accounts for the interaction between DNP and CCl4.
Positive_regulation (DNP-induced) of Positive_regulation (activation) of CCl4 associated with hypoxia
3) Confidence 0.44 Published 1981 Journal Toxicol. Lett. Section Abstract Doc Link 7314128 Disease Relevance 0.17 Pain Relevance 0.15
Increased activation of Bax and Bid in CCl4 treated rats indicates apoptosis is more in these rats.
Positive_regulation (Increased) of Positive_regulation (activation) of CCl4 associated with apoptosis
4) Confidence 0.43 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.88 Pain Relevance 0.06

General Comments

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