INT4736

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 67
Total Number 72
Disease Relevance 17.15
Pain Relevance 14.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
neurons 15
striatum 4
motoneurons 4
follicles 4
IPN 3
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 128 100.00 Very High Very High Very High
Dopamine 54 100.00 Very High Very High Very High
Somatostatin 38 100.00 Very High Very High Very High
Serotonin 19 100.00 Very High Very High Very High
dopamine receptor 8 100.00 Very High Very High Very High
Cholecystokinin 7 100.00 Very High Very High Very High
Neurotransmitter 116 99.98 Very High Very High Very High
substance P 65 99.94 Very High Very High Very High
gABA 79 99.90 Very High Very High Very High
Nerve growth factor 189 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 71 99.96 Very High Very High Very High
Disease 132 99.90 Very High Very High Very High
Aging 21 99.52 Very High Very High Very High
Diabetes Mellitus 229 99.28 Very High Very High Very High
Alzheimer's Dementia 29 99.16 Very High Very High Very High
Down Syndrome 3 99.12 Very High Very High Very High
Cv Unclassified Under Development 18 98.92 Very High Very High Very High
Death 55 98.84 Very High Very High Very High
Apoptosis 44 98.62 Very High Very High Very High
Increased Venous Pressure Under Development 62 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, prenatal exposure to methadone appears to produce a delay in the expression of ChAT in striatal neurons.
Gene_expression (expression) of ChAT in neurons associated with methadone
1) Confidence 0.77 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149590 Disease Relevance 0 Pain Relevance 0.60
The effect of prenatal exposure to methadone via maternal osmotic minipumps on the expression of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) has been studied by light microscopy in the striatum of male and female rats.
Gene_expression (expression) of ChAT in striatum associated with methadone
2) Confidence 0.77 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149590 Disease Relevance 0 Pain Relevance 0.32
The effect of prenatal exposure to methadone via maternal osmotic minipumps on the expression of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) has been studied by light microscopy in the striatum of male and female rats.
Gene_expression (expression) of choline acetyltransferase in striatum associated with methadone
3) Confidence 0.77 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149590 Disease Relevance 0 Pain Relevance 0.32
Attention was paid to the temporal relationships between the expression of ChAT, the presence of other putative neuroactive substances, the onset of hearing and other developmental phenomena.
Gene_expression (expression) of ChAT
4) Confidence 0.77 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7842517 Disease Relevance 0 Pain Relevance 0.13
To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury.
Spec (investigated) Gene_expression (expression) of choline acetyltransferase in motor neuron associated with aging, injury and alzheimer's dementia
5) Confidence 0.75 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.51 Pain Relevance 0
In contrast, after avulsion, expression of APP and A/beta were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed.
Gene_expression (expression) of ChaT in spinal
6) Confidence 0.75 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.46 Pain Relevance 0
To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury.
Spec (investigated) Gene_expression (expression) of ChaT in motor neuron associated with aging, injury and alzheimer's dementia
7) Confidence 0.75 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.51 Pain Relevance 0
RT97 expression was present in approximately 80% (+/-3.7) of surviving motoneurons at 7 dpo, and it was related to the regenerative response of motoneurons, as revealed by decreased ChAT expression and co-localization with GAP43.
Gene_expression (expression) of ChAT in motoneurons
8) Confidence 0.71 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0.04
We used quantitative double-label in situ hybridization to examine in rat brain the expression of NMDAR1, NMDAR2A, NMDAR2B, and NMDAR2C mRNA in six neurochemically defined populations of striatal neurons: preproenkephalin (ENK) and preprotachykinin (SP) expressing projection neurons, and somatostatin (SOM), glutamic acid decarboxylase 67 (GAD67), parvalbumin (PARV), and choline acetyltransferase (ChAT) expressing interneurons.
Gene_expression (expressing) of choline acetyltransferase in neurons associated with somatostatin and projection neuron
9) Confidence 0.68 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.35
We used quantitative double-label in situ hybridization to examine in rat brain the expression of NMDAR1, NMDAR2A, NMDAR2B, and NMDAR2C mRNA in six neurochemically defined populations of striatal neurons: preproenkephalin (ENK) and preprotachykinin (SP) expressing projection neurons, and somatostatin (SOM), glutamic acid decarboxylase 67 (GAD67), parvalbumin (PARV), and choline acetyltransferase (ChAT) expressing interneurons.
Gene_expression (expressing) of ChAT in neurons associated with somatostatin and projection neuron
10) Confidence 0.68 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.34
The presence of cholinergic input to the red nucleus (RN) in the cat is demonstrated by choline acetyltransferase (ChAT) staining; however, it is unclear what effect this cholinergic input has on neurons of the RN.
Gene_expression (staining) of ChAT in neurons
11) Confidence 0.68 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8570084 Disease Relevance 0 Pain Relevance 0.14
The presence of cholinergic input to the red nucleus (RN) in the cat is demonstrated by choline acetyltransferase (ChAT) staining; however, it is unclear what effect this cholinergic input has on neurons of the RN.
Gene_expression (staining) of choline acetyltransferase in neurons
12) Confidence 0.68 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8570084 Disease Relevance 0 Pain Relevance 0.14
In this study, we have used immunocytochemistry to detect the presence of choline acetyltransferase (ChAT), the synthesizing enzyme of ACh, in efferent olivocochlear terminals during the development of the rat.
Gene_expression (presence) of choline acetyltransferase
13) Confidence 0.67 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7842517 Disease Relevance 0 Pain Relevance 0.05
In this study, we have used immunocytochemistry to detect the presence of choline acetyltransferase (ChAT), the synthesizing enzyme of ACh, in efferent olivocochlear terminals during the development of the rat.
Gene_expression (presence) of ChAT
14) Confidence 0.67 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7842517 Disease Relevance 0 Pain Relevance 0.05
Sympathetic preganglionic neurons (SPN) coexpress the acetylcholine (ACh)-synthesizing enzyme choline acetyltransferase and different peptides in their cell bodies, but can express them independently in separate varicosities, indicating that SPN segregate transmitters to different synapses.
Gene_expression (coexpress) of choline acetyltransferase in SPN associated with urological neuroanatomy and increased venous pressure under development
15) Confidence 0.66 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 0.52 Pain Relevance 0.13
The subnuclear and synaptic staining patterns for acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) activity were studied in the rat interpeduncular nucleus (IPN) using histochemical and immunohistochemical methods.
Gene_expression (activity) of ChAT in IPN associated with ipn
16) Confidence 0.66 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2337826 Disease Relevance 0 Pain Relevance 0.22
The subnuclear and synaptic staining patterns for acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) activity were studied in the rat interpeduncular nucleus (IPN) using histochemical and immunohistochemical methods.
Gene_expression (activity) of choline acetyltransferase in IPN associated with ipn
17) Confidence 0.66 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2337826 Disease Relevance 0 Pain Relevance 0.22
A similar pattern of SP staining resulted following habenular transplants into neonatal hosts, but in addition there was a partial recovery of normal ChAT staining in cholinergic subnuclei and anomalous ChAT staining in normally peptidergic subnuclei.
Gene_expression (staining) of ChAT associated with substance p
18) Confidence 0.66 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1494956 Disease Relevance 0 Pain Relevance 0.92
NMDAR1 was expressed by all striatal neurons: strongly in ENK, SP, PARV and ChAT neurons, and less intensely in SOM and GAD67 positive cells.
Gene_expression (expressed) of ChAT in neurons associated with somatostatin
19) Confidence 0.59 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.38
ChAT-containing neurons were present in the ventral portion of the medial habenula, ChAT-stained axons were present in the FR and ChAT-stained axons and terminals were present in the rostral, central and intermediate subnuclei of the IPN.
Gene_expression (present) of ChAT in habenula associated with ipn
20) Confidence 0.59 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445413 Disease Relevance 0 Pain Relevance 0.51

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