INT4737

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 5.73
Pain Relevance 9.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
neurons 8
striatum 3
caudate putamen 2
NAc 1
projection neurons 1
Ppp1r1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 277 100.00 Very High Very High Very High
amygdala 69 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
adenocard 3 100.00 Very High Very High Very High
cocaine 18 99.84 Very High Very High Very High
Morphine 21 99.58 Very High Very High Very High
fluoxetine 3 99.04 Very High Very High Very High
Glutamate 22 98.80 Very High Very High Very High
projection neuron 12 98.68 Very High Very High Very High
Opioid receptor 1 1 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 110 99.72 Very High Very High Very High
Disease 602 99.68 Very High Very High Very High
Urological Neuroanatomy 6 98.20 Very High Very High Very High
Dyskinesias 16 97.76 Very High Very High Very High
Toxicity 143 97.40 Very High Very High Very High
Targeted Disruption 89 96.48 Very High Very High Very High
Aging 452 95.84 Very High Very High Very High
Cognitive Disorder 12 89.88 High High
Aids-related Complex 15 85.60 High High
Neurodegenerative Disease 68 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the striatum, DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) is highly expressed by virtually all projection medium-sized spiny neurons. cAMP-dependent phosphorylation of DARPP-32 is stimulated via activation of dopamine D1 receptors in striatonigral neurons, and via activation of adenosine A2A receptors in striatopallidal neurons.
Gene_expression (expressed) of DARPP-32 in neurons associated with adenocard and dopamine
1) Confidence 0.67 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.35
Increased levels of DARPP-32 could reflect a common functional effect on frontal cortex of long-term exposure to lithium and some other antidepressant medications, an effect possibly related to the clinical actions of these drugs.
Gene_expression (levels) of DARPP-32 in frontal cortex associated with antidepressant and urological neuroanatomy
2) Confidence 0.60 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1494903 Disease Relevance 0.34 Pain Relevance 0.31
These grafts are characterized by discrete patches of DARPP-32 messenger RNA expression, which cover approximately one-third of the cross-sectional graft area.
Gene_expression (expression) of DARPP-32
3) Confidence 0.56 Published 1995 Journal Neuroscience Section Abstract Doc Link 7708203 Disease Relevance 0 Pain Relevance 0.29
Morphine challenge increased levels of phospho-Thr75 DARPP-32 and decreased levels of phospho-Thr34 DARPP-32 in a time-dependent manner in the CPu and NAc.
Gene_expression (levels) of DARPP-32 in NAc associated with nucleus accumbens and morphine
4) Confidence 0.56 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.23
In line with this, neuroprotective strategies not directly targeting transcription (e.g. chaperones and calcineurin) block the loss of DARPP32 produced by mutant Htt in our rat model [12], [13], [61].
Gene_expression (produced) of DARPP32
5) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.15 Pain Relevance 0
The reduction of DARPP-32 expression in the striatum of old rats, induced by a lentiviral vector encoding mutant Htt, indicates that these rats were more vulnerable to mutant Htt than young animals.
Gene_expression (expression) of DARPP-32 in striatum
6) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.66 Pain Relevance 0
DARPP-32 expression is regulated by the nuclear factor cAMP-response-element-binding protein (CREB).
Gene_expression (expression) of DARPP-32
7) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.73 Pain Relevance 0.05
Our data demonstrated significantly increased levels of PDyn mRNA and phospho-Thr-34 DARPP-32 and significantly decreased phospho-Thr-75 DARPP-32 in LID rats compared with control and l-dopa treated groups.
Gene_expression (levels) of DARPP-32 associated with dyskinesias
8) Confidence 0.51 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17884291 Disease Relevance 0.45 Pain Relevance 0.09
Nevertheless, we found that neuroleptics of both classes regulated transcription factor expression in overlapping populations of striatal neurons expressing enkephalin or DARPP-32.
Gene_expression (expressing) of DARPP-32 in neurons associated with enkephalin
9) Confidence 0.48 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8891947 Disease Relevance 0.09 Pain Relevance 0.10
A significant decrease in both phospho-CREB at Ser133 and phospho-DARPP-32 at Thr34 in the rat caudate putamen was produced by cocaine, GBR 12909, fluoxetine or nisoxetine.
Gene_expression (produced) of phospho-DARPP-32 in caudate putamen associated with fluoxetine and cocaine
10) Confidence 0.47 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.69
Loss of striatal DARPP-32 expression is greater in old rats
Gene_expression (expression) of DARPP-32
11) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.18 Pain Relevance 0
At 12 weeks post-infection, in lenti-Htt171-18Q-infected rats, the loss of striatal DARPP-32 expression was limited, and restricted to the vicinity of the needle track.
Gene_expression (expression) of DARPP-32 associated with infection
12) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.23 Pain Relevance 0
DARPP-32, which is expressed by 96% of medium spiny striatal projection neurons, is down-regulated in the HD striatum [22], in HD transgenic mice [23], [24] and in a lentivirus-based HD rat model at 8 weeks post-infection [11].
Gene_expression (expressed) of DARPP-32 in projection neurons associated with targeted disruption, projection neuron, disease and infection
13) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.91 Pain Relevance 0.05
In contrast, a clear loss of striatal DARPP-32 expression (1.5–2.0 mm3) was observed in Htt171-82Q-injected striata relative to lenti-Htt-18Q-injected striata in both age groups.
Gene_expression (expression) of DARPP-32
14) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.35 Pain Relevance 0
The reduction of DARPP-32 immunoreactivity in our HD rat model probably results from a loss of expression of DARPP-32 in dysfunctional neurons and/or an actual loss of striatal neurons.
Gene_expression (expression) of DARPP-32 in neurons associated with disease
15) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.87 Pain Relevance 0.04
In previous studies, the loss of DARPP32 phenotype in our HD rat model has been correlated with loss of the neuronal marker NeuN, suggesting that it represents severe dysfunction and/or disappearance of striatal neurons and not only transcriptional alterations [11].
Gene_expression (phenotype) of DARPP32 in neurons associated with disease
16) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.10 Pain Relevance 0
They contained striatum-like patches with neurons expressing many of the neurochemicals characteristic of striatum (ACh, ChAT, calbindin-D28KD, met-enkephalin, and dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein-32,000 or DARPP-32), and these patches were surrounded by graft tissue expressing few of these striatal markers.
Gene_expression (expressing) of DARPP-32 in neurons associated with adenocard, dopamine and enkephalin
17) Confidence 0.45 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1279138 Disease Relevance 0 Pain Relevance 0.28
Interestingly, the cellular expression of glutamate decarboxylase messenger RNA was considerably higher in the non-DARPP-32 expressing regions than that in the DARPP-32 messenger RNA-rich areas, where it approximated that of the intact striatum.
Gene_expression (expressing) of non-DARPP-32 in striatum associated with glutamate
18) Confidence 0.44 Published 1995 Journal Neuroscience Section Abstract Doc Link 7708203 Disease Relevance 0 Pain Relevance 0.24
Determination of striatal DARPP-32-depleted volume
Gene_expression (volume) of DARPP-32-depleted
19) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0 Pain Relevance 0.07
Interestingly, the volume of the DARPP-32-depleted region in Htt171-82Q-injected striata was significantly greater (+59.6%, p<0.05) in older rats than in younger rats.
Gene_expression (region) of DARPP-32-depleted
20) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.38 Pain Relevance 0

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