INT47372

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Context Info
Confidence 0.18
First Reported 1981
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.14
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurites 1
neural 1
ap (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 846 100.00 Very High Very High Very High
Enkephalin 9 99.36 Very High Very High Very High
epidural 3 98.96 Very High Very High Very High
analgesia 3 98.24 Very High Very High Very High
halothane 1 93.88 High High
Mechanotransduction 57 91.64 High High
dorsal root ganglion 54 90.08 High High
rheumatoid arthritis 6 89.36 High High
ischemia 3 85.68 High High
TRP channel 3 85.56 High High
Disease Link Frequency Relevance Heat
Osteoporosis 11 95.76 Very High Very High Very High
Metastasis 4 92.40 High High
Hypoalbuminemia 1 91.44 High High
Ganglion Cysts 57 90.08 High High
Rheumatoid Arthritis 10 89.36 High High
Asthma 3 88.20 High High
Systemic Lupus Erythematosus 6 87.84 High High
Reperfusion Injury 2 86.44 High High
Cv Unclassified Under Development 3 85.68 High High
Disease 15 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multiple injections of MENK (8 x 10 mg/kg) induced a significant decrease in AP activity in the serum and no change in the unsedimentable activities of AP or BG.
Neg (no) Regulation (change) of AP associated with enkephalin
1) Confidence 0.18 Published 1993 Journal Biomed. Pharmacother. Section Abstract Doc Link 8329664 Disease Relevance 0 Pain Relevance 0.64
Thus, we are confident that our principal conclusion is robust; namely, that Na channel noise in the early rising phase AP (around AP threshold depolarizations) varies the speed of membrane depolarization to the AP peak, and in turn causes fluctuations in the axial current driving the AP.


Regulation (around) of AP associated with action potential
2) Confidence 0.17 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.44
The time series recorded at each position are superimposed, after having been aligned at the instant when the membrane potential crosses its half AP peak value.
Regulation (crosses) of AP associated with action potential
3) Confidence 0.17 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.36
Thus, we are confident that our principal conclusion is robust; namely, that Na channel noise in the early rising phase AP (around AP threshold depolarizations) varies the speed of membrane depolarization to the AP peak, and in turn causes fluctuations in the axial current driving the AP.


Regulation (around) of AP associated with action potential
4) Confidence 0.17 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.44
This is due to collaborative effects among Na channels in the resting axon ahead of an AP (see Figure 6), where the random opening of nearby Na+ channels pre-depolarizes a region of the membrane by a few millivolts.
Regulation (effects) of AP associated with action potential
5) Confidence 0.17 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.33
Gene expression profiles reflected the AP and mineralization staining data results with SB431542 able to augment osteogenesis alone and in combination with BMP-2.
Regulation (reflected) of AP
6) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.27 Pain Relevance 0
As it was evident that at least one of the cytoskeletal components, i.e., microtubules, influenced AP firing, we then proceeded to examine another major cytoskeletal constituent, actin [19].
Regulation (influenced) of AP associated with action potential
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0 Pain Relevance 0.28
While the neurites showed specific mechanosensitive responses when probing their AP, the blocking of mechanosensitive channels had little effect on the AP response.


Neg (little) Regulation (effect) of AP in neurites associated with action potential
8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.15 Pain Relevance 0.37
This allowed us to investigate the coupled behavior of mechanical stimulation and substrate interactions, with respect to cell structure, for affecting the critical neural function of action potential (AP) firing.
Regulation (affecting) of AP in neural associated with action potential
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.28 Pain Relevance 0.27
However, they do not act specifically on AP [19].
Neg (not) Regulation (act) of AP
10) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.70 Pain Relevance 0.13
Multivariate analyses confirmed the independent prognostic value of PS and AP levels.
Neg (independent) Regulation (value) of AP
11) Confidence 0.01 Published 2003 Journal Clin Colorectal Cancer Section Abstract Doc Link 12620142 Disease Relevance 0.74 Pain Relevance 0.07
Surgery under general anaesthesia was followed by increased levels of bilirubin, LDH, CPK, glucose and cortisol, whereas AP and ALAT were unaffected by surgery.
Neg (unaffected) Regulation (unaffected) of AP
12) Confidence 0.01 Published 1981 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 7324821 Disease Relevance 0 Pain Relevance 0.45

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